	   SnapGene      0µgtttacccgccaatatatcctgtcaaacactgatagtttaaactgaaggcgggaaacgacaatctgatccaagctcaagctaagctcacgtgacggaattaagcttCGTTGAACAACGGAAACTCGACTTGCCTTCCGCACAATACATCATTTCTTCTTAGCTTTTTTTCTTCTTCTTCGTTCATACAGTTTTTTTTTGTTTATCAGCTTACATTTTCTTGAACCGTAGCTTTCGTTTTCTTCTTTTTAACTTTCCATTCGGAGTTTTTGTATCTTGTTTCATAGTTTGTCCCAGGATTAGAATGATTAGGCATCGAACCTTCAAGAATTTGATTGAATAAAACATCTTCATTCTTAAGATATGAAGATAATCTTCAAAAGGCCCCTGGGAATCTGAAAGAAGAGAAGCAGGCCCATTTATATGGGAAAGAACAATAGTATTTCTTATATAGGCCCATTTAAGTTGAAAACAATCTTCAAAAGTCCCACATCGCTTAGATAAGAAAACGAAGCTGAGTTTATATACAGCTAGAGTCGAAGTAGTGATTGGCACTCTCTTGTAGCTGACGGTTTTAGAGCTAGAAATAGCAAGTTAAAATAAGGCTAGTCCGTTATCAACTTGAAAAAGTGGCACCGAGTCGGTGCTTTTTTTGTCCCTTCGAAGGGCAATTCTGCAGATATCCATCACACTGGCGGCCGCTCGAGGTCGACGGTATCGATaagcttgatatcgaattcctgcagtgcagcgtgacccggtcgtgcccctctctagagataatgagcattgcatgtctaagttataaaaaattaccacatattttttttgtcacacttgtttgaagtgcagtttatctatctttatacatatatttaaactttactctacgaataatataatctatagtactacaataatatcagtgttttagagaatcatataaatgaacagttagacatggtctaaaggacaattgagtattttgacaacaggactctacagttttatctttttagtgtgcatgtgttctcctttttttttgcaaatagcttcacctatataatacttcatccattttattagtacatccatttagggtttagggttaatggtttttatagactaatttttttagtacatctattttattctattttagcctctaaattaagaaaactaaaactctattttagtttttttatttaataatttagatataaaatagaataaaataaagtgactaaaaattaaacaaataccctttaagaaattaaaaaaactaaggaaacatttttcttgtttcgagtagataatgccagcctgttaaacgccgtcgacgagtctaacggacaccaaccagcgaaccagcagcgtcgcgtcgggccaagcgaagcagacggcacggcatctctgtcgctgcctctggacccctctcgagagttccgctccaccgttggacttgctccgctgtcggcatccagaaatgcgtggcggagcggcagacgtgagccggcacggcaggcggcctcctcctcctctcacggcacggcagctacgggggattcctttcccaccgctccttcgctttcccttcctcgcccgccgtaataaatagacaccccctccacaccctctttccccaacctcgtgttgttcggagcgcacacacacacaaccagatctcccccaaatccacccgtcggcacctccgcttcaaggtacgccgctcgtcctccccccccccccctctctaccttctctagatcggcgttccggtccatggttagggcccggtagttctacttctgttcatgtttgtgttagatccgtgtttgtgttagatccgtgctgctagcgttcgtacacggatgcgacctgtacgtcagacacgttctgattgctaacttgccagtgtttctctttggggaatcctgggatggctctagccgttccgcagacgggatcgatttcatgattttttttgtttcgttgcatagggtttggtttgcccttttcctttatttcaatatatgccgtgcacttgtttgtcgggtcatcttttcatgcttttttttgtcttggttgtgatgatgtggtctggttgggcggtcgttctagatcggagtagaattctgtttcaaactacctggtggatttattaattttggatctgtatgtgtgtgccatacatattcatagttacgaattgaagatgatggatggaaatatcgatctaggataggtatacatgttgatgcgggttttactgatgcatatacagagatgctttttgttcgcttggttgtgatgatgtggtgtggttgggcggtcgttcattcgttctagatcggagtagaatactgtttcaaactacctggtgtatttattaattttggaactgtatgtgtgtgtcatacatcttcatagttacgagtttaagatggatggaaatatcgatctaggataggtatacatgttgatgtgggttttactgatgcatatacatgatggcatatgcagcatctattcatatgctctaaccttgagtacctatctattataataaacaagtatgttttataattattttgatcttgatatacttggatgatggcatatgcagcagctatatgtggatttttttagccctgccttcatacgctatttatttgcttggtactgtttcttttgtcgatgctcaccctgttgtttggtgttacttctgcagcccgggggatccccaatacttgtatggccgcggccgctctagatggattacaaggaccacgacggggattacaaggaccacgacattgattacaaggatgatgatgacaagatggctccgaagaagaagaggaaggttggcatccacggggtgccagctgctgacaagaagtactcgatcggcctcgccattgggactaactctgttggctgggccgtgatcaccgacgagtacaaggtgccctcaaagaagttcaaggtcctgggcaacaccgatcggcattccatcaagaagaatctcattggcgctctcctgttcgacagcggcgagacggctgaggctacgcggctcaagcgcaccgcccgcaggcggtacacgcgcaggaagaatcgcatctgctacctgcaggagattttctccaacgagatggcgaaggttgacgattctttcttccacaggctggaggagtcattcctcgtggaggaggataagaagcacgagcggcatccaatcttcggcaacattgtcgacgaggttgcctaccacgagaagtaccctacgatctaccatctgcggaagaagctcgtggactccacagataaggcggacctccgcctgatctacctcgctctggcccacatgattaagttcaggggccatttcctgatcgagggggatctcaacccggacaatagcgatgttgacaagctgttcatccagctcgtgcagacgtacaaccagctcttcgaggagaaccccattaatgcgtcaggcgtcgacgcgaaggctatcctgtccgctaggctctcgaagtctcggcgcctcgagaacctgatcgcccagctgccgggcgagaagaagaacggcctgttcgggaatctcattgcgctcagcctggggctcacgcccaacttcaagtcgaatttcgatctcgctgaggacgccaagctgcagctctccaaggacacatacgacgatgacctggataacctcctggcccagatcggcgatcagtacgcggacctgttcctcgctgccaagaatctgtcggacgccatcctcctgtctgatattctcagggtgaacaccgagattacgaaggctccgctctcagcctccatgatcaagcgctacgacgagcaccatcaggatctgaccctcctgaaggcgctggtcaggcagcagctccccgagaagtacaaggagatcttcttcgatcagtcgaagaacggctacgctgggtacattgacggcggggcctctcaggaggagttctacaagttcatcaagccgattctggagaagatggacggcacggaggagctgctggtgaagctcaatcgcgaggacctcctgaggaagcagcggacattcgataacggcagcatcccacaccagattcatctcggggagctgcacgctatcctgaggaggcaggaggacttctaccctttcctcaaggataaccgcgagaagatcgagaagattctgactttcaggatcccgtactacgtcggcccactcgctaggggcaactcccgcttcgcttggatgacccgcaagtcagaggagacgatcacgccgtggaacttcgaggaggtggtcgacaagggcgctagcgctcagtcgttcatcgagaggatgacgaatttcgacaagaacctgccaaatgagaaggtgctccctaagcactcgctcctgtacgagtacttcacagtctacaacgagctgactaaggtgaagtatgtgaccgagggcatgaggaagccggctttcctgtctggggagcagaagaaggccatcgtggacctcctgttcaagaccaaccggaaggtcacggttaagcagctcaaggaggactacttcaagaagattgagtgcttcgattcggtcgagatctctggcgttgaggaccgcttcaacgcctccctggggacctaccacgatctcctgaagatcattaaggataaggacttcctggacaacgaggagaatgaggatatcctcgaggacattgtgctgacactcactctgttcgaggaccgggagatgatcgaggagcgcctgaagacttacgcccatctcttcgatgacaaggtcatgaagcagctcaagaggaggaggtacaccggctgggggaggctgagcaggaagctcatcaacggcattcgggacaagcagtccgggaagacgatcctcgacttcctgaagagcgatggcttcgcgaaccgcaatttcatgcagctgattcacgatgacagcctcacattcaaggaggatatccagaaggctcaggtgagcggccagggggactcgctgcacgagcatatcgcgaacctcgctggctcgccagctatcaagaaggggattctgcagaccgtgaaggttgtggacgagctggtgaaggtcatgggcaggcacaagcctgagaacatcgtcattgagatggcccgggagaatcagaccacgcagaagggccagaagaactcacgcgagaggatgaagaggatcgaggagggcattaaggagctggggtcccagatcctcaaggagcacccggtggagaacacgcagctgcagaatgagaagctctacctgtactacctccagaatggccgcgatatgtatgtggaccaggagctggatattaacaggctcagcgattacgacgtcgatgccatcgttccacagtcattcctgaaggatgactccattgacaacaaggtcctcaccaggtcggacaagaaccggggcaagtctgataatgttccttcagaggaggtcgttaagaagatgaagaactactggcgccagctcctgaatgccaagctgatcacgcagcggaagttcgataacctcacaaaggctgagaggggcgggctctctgagctggacaaggcgggcttcatcaagaggcagctggtcgagacacggcagatcactaagcacgttgcgcagattctcgactcacggatgaacactaagtacgatgagaatgacaagctgatccgcgaggtgaaggtcatcaccctgaagtcaaagctcgtctccgacttcaggaaggatttccagttctacaaggttcgggagatcaacaattaccaccatgcccatgacgcgtacctgaacgcggtggtcggcacagctctgatcaagaagtacccaaagctcgagagcgagttcgtgtacggggactacaaggtttacgatgtgaggaagatgatcgccaagtcggagcaggagattggcaaggctaccgccaagtacttcttctactctaacattatgaatttcttcaagacagagatcactctggccaatggcgagatccggaagcgccccctcatcgagacgaacggcgagacgggggagatcgtgtgggacaagggcagggatttcgcgaccgtcaggaaggttctctccatgccacaagtgaatatcgtcaagaagacagaggtccagactggcgggttctctaaggagtcaattctgcctaagcggaacagcgacaagctcatcgcccgcaagaaggactgggatccgaagaagtacggcgggttcgacagccccactgtggcctactcggtcctggttgtggcgaaggttgagaagggcaagtccaagaagctcaagagcgtgaaggagctgctggggatcacgattatggagcgctccagcttcgagaagaacccgatcgatttcctggaggcgaagggctacaaggaggtgaagaaggacctgatcattaagctccccaagtactcactcttcgagctggagaacggcaggaagcggatgctggcttccgctggcgagctgcagaaggggaacgagctggctctgccgtccaagtatgtgaacttcctctacctggcctcccactacgagaagctcaagggcagccccgaggacaacgagcagaagcagctgttcgtcgagcagcacaagcattacctcgacgagatcattgagcagatttccgagttctccaagcgcgtgatcctggccgacgcgaatctggataaggtcctctccgcgtacaacaagcaccgcgacaagccaatcagggagcaggctgagaatatcattcatctcttcaccctgacgaacctcggcgcccctgctgctttcaagtacttcgacacaactatcgatcgcaagaggtacacaagcactaaggaggtcctggacgcgaccctcatccaccagtcgattaccggcctctacgagacgcgcatcgacctgtctcagctcgggggcgacaagcggccagcggcgacgaagaaggcggggcaggcgaagaagaagaagtccgggtcctcggggtcgccaaagaagaagcggaaggtcggctcaagcgggtcaccaaagaagaagcggaaggtcggctcgatggacgctaagtccctcaccgcttggagccgcaccctggtgacgttcaaggacgtgttcgtcgatttcacaagggaggagtggaagctcctggacactgctcagcagatcgtttaccggaacgtgatgctggagaactacaagaacctcgtgtccctcggctaccagctgacgaagccggatgttattctccgcctggagaagggcgaggagcccgggtcccctaagaagaagcggaaggtcggctcctacccatacgatgtccctgactacgcctcatgagctcaggcctccatacaagtattggggatccgaatttccccgatcgttcaaacatttggcaataaagtttcttaagattgaatcctgttgccggtcttgcgatgattatcatataatttctgttgaattacgttaagcatgtaataattaacatgtaatgcatgacgttatttatgagatgggtttttatgattagagtcccgcaattatacatttaatacgcgatagaaaacaaaatatagcgcgcaaactaggataaattatcgcgcgcggtgtcatctatgttactagatcgggaattcactggccgtcgttttacaacgtcgtgactgggaaaaccctggcgttacccaacttaatcgccttgcagcacatccccctttcgccaggggtaccgagctctagaattcgaggcggtttgcgtattggctagagcagcttgccaacatggtggagcacgacactctcgtctactccaagaatatcaaagatacagtctcagaagaccaaagggctattgagacttttcaacaaagggtaatatcgggaaacctcctcggattccattgcccagctatctgtcacttcatcaaaaggacagtagaaaaggaaggtggcacctacaaatgccatcattgcgataaaggaaaggctatcgttcaagatgcctctgccgacagtggtcccaaagatggacccccacccacgaggagcatcgtggaaaaagaagacgttccaaccacgtcttcaaagcaagtggattgatgtgataacatggtggagcacgacactctcgtctactccaagaatatcaaagatacagtctcagaagaccaaagggctattgagacttttcaacaaagggtaatatcgggaaacctcctcggattccattgcccagctatctgtcacttcatcaaaaggacagtagaaaaggaaggtggcacctacaaatgccatcattgcgataaaggaaaggctatcgttcaagatgcctctgccgacagtggtcccaaagatggacccccacccacgaggagcatcgtggaaaaagaagacgttccaaccacgtcttcaaagcaagtggattgatgtgatatctccactgacgtaagggatgacgcacaatcccactatccttcgcaagaccttcctctatataaggaagttcatttcatttggagaggacacgctgaaatcaccagtctctctctacaaatctatctctctcgagtctaccatgagcccagaacgacgcccggccgacatccgccgtgccaccgaggcggacatgccggcggtctgcaccatcgtcaaccactacatcgagacaagcacggtcaacttccgtaccgagccgcaggaaccgcaggagtggacggacgacctcgtccgtctgcgggagcgctatccctggctcgtcgccgaggtggacggcgaggtcgccggcatcgcctacgcgggcccctggaaggcacgcaacgcctacgactggacggccgagtcgaccgtgtacgtctccccccgccaccagcggacgggactgggctccacgctctacacccacctgctgaagtccctggaggcacagggcttcaagagcgtggtcgctgtcatcgggctgcccaacgacccgagcgtgcgcatgcacgaggcgctcggatatgccccccgcggcatgctgcgggcggccggcttcaagcacgggaactggcatgacgtgggtttctggcagctggacttcagcctgccggtaccgccccgtccggtcctgcccgtcaccgagatttgactcgagtttctccataataatgtgtgagtagttcccagataagggaattagggttcctatagggtttcgctcatgtgttgagcatataagaaacccttagtatgtatttgtatttgtaaaatacttctatcaataaaatttctaattcctaaaaccaaaatccagtactaaaatccagatcccccgaattaattcggcgttaattcagtacattaaaaacgtccgcaatgtgttattaagttgtcactagtcaggttaactcaattcggcgttaattcagtacattaaaaacgtccgcaatgtgttattaagttgtctaagcgtcaatttgtttacaccacaatatatcctgccaccagccagccaacagctccccgaccggcagctcggcacaaaatcaccactcgatacaggcagcccatcagtccgggacggcgtcagcgggagagccgttgtaaggcggcagactttgctcatgttaccgatgctattcggaagaacggcaactaagctgccgggtttgaaacacggatgatctcgcggagggtagcatgttgattgtaacgatgacagagcgttgctgcctgtgatcacttaagtaactaactaacaggaagagtttgtagaaacgcaaaaaggccatccgtcaggatggccttctgcttagtttgatgcctggcagtttatggcgggcgtcctgcccgccaccctccgggccgttgcttcacaacgttcaaatccgctcccggcggatttgtcctactcaggagagcgttcaccgacaaacaacagataaaacgaaaggcccagtcttccgactgagcctttcgttttatttgatgcctggcagttccctactctcgcttagtagttagacgtccccgagatccatgctagaccatgaatccagaagcccgagaggttgccgcctttcgggctttttctttttcaaaaaaaaaaatttataaaacgatctgttgcggccggccgccgggttgtgggcaaaggcgctcgacggtgggcaaccgcttgcggttgtccacgggcggagccggtgcgcgtagcgcattgtccacaagccaagggcgaccaataattgatatatatattcataattgaaaagctaattgaacatactacttgctgtaactacttgccggagcgaggggtgtttgcaagctgttgatctgaaagggctattagcgttctcacgtgcctttttgattagcgatttcacgtgaccttattagcgatttcacgtactccgattagcgatttcacgtaccctgattagcgatttcacgtggatagtttttggagcgggccggaaagccccgtgaatcaaggctttgcggggcattagcggtttcacgtggataactaccctctatccacaggcttccggggataaaaaagcccgctcgacggcgggctgttggatggggatctagcggtaatacggttatccacagaatcaggggataacgcaggaaagaacatgtgagcaaaaggccagcaaaaggccaggaaccgtaaaaaggccgcgttgctggcgtttttccataggctccgcccccctgacgagcatcacaaaaatcgacgctcaagtcagaggtggcgaaacccgacaggactataaagataccaggcgtttccccctggaagctccctcgtgcgctctcctgttccgaccctgccgcttaccggatacctgtccgcctttctcccttcgggaagcgtggcgctttctcatagctcacgctgtaggtatctcagttcggtgtaggtcgttcgctccaagctgggctgtgtgcacgaaccccccgttcagcccgaccgctgcgccttatccggtaactatcgtcttgagtccaacccggtaagacacgacttatcgccactggcagcagccactggtaacaggattagcagagcgaggtatgtaggcggtgctacagagttcttgaagtggtggcctaactacggctacactagaagaacagtatttggtatctgcgctctgctgaagccagttaccttcggaaaaagagttggtagctcttgatccggcaaacaaaccaccgctggtagcggtggtttttttgtttgcaagcagcagattacgcgcagaaaaaaaggatctcaagaagatcctttgatcttttctaccgggtctgacgctcagtggaacggggcccaatctgaataatgttacaaccaattaaccaattctgattagaaaaactcatcgagcatcaaatgaaactgcaatttattcatatcaggattatcaataccatatttttgaaaaagccgtttctgtaatgaaggagaaaactcaccgaggcagttccataggatggcaagatcctggtatcggtctgcgattccgactcgtccaacatcaatacaacctattaatttcccctcgtcaaaaataaggttatcaagtgagaaatcaccatgagtgacgactgaatccggtgagaatggcaaaagtttatgcatttctttccagacttgttcaacaggccagccattacgctcgtcatcaaaatcactcgcatcaaccaaaccgttattcattcgtgattgcgcctgagcgagacgaaatacgcgatcgctgttaaaaggacaattacaaacaggaatcgaatgcaaccggcgcagggacactgccagcgcatcaacaatattttcacctgaatcaggatattcttctaatacctggaatgctgtttttccggggatcgcagtggtgagtaaccatgcatcatcaggagtacggataaaatgcttgatggtcggaagaggcataaattccgtcagccagtttagtctgaccatctcatctgtaacatcattggcaacgctacctttgccatgtttcagaaacaactctggcgcatcgggcttcccatacaagcgatagattgtcgcacctgattgcccgacattatcgcgagcccatttatacccatataaatcagcatccatgttggaatttaatcgcggcctcgacgtttcccgttgaatatggctcataacaccccttgtattactgtttatgtaagcagacagttttattgttcatgatgatatatttttatcttgtgcaatgtaacatcagagattttgagacacgggccagagctgcagtttgatcccgaggggaaccctgtggttgacatgcacatacaaatggacgaacggataaaccttttcacgcccttttaaatatccgttattctaataaacgctcttttctcttag  gk   +   3      2   H   >   C   <   #      (   -   =   B   4   1   F   B   "   >   z   +   2   -   D   3   <   I   =   :   $   '   /   %                  )   *   !   @   :   -   $      )   <   3      %   J   %   ,   (   E   &   '   N   -   1   +   .   *   e   .   7   &   m   B   &      &   .   #   :   7   K   &   d   c   /   H   3   Q   )   +      4   2   &   $   /   %   .   $   3   (   (      ;   =   $   '   8   E   /   <   =   9   5   1   >       -   '   N   ,   $      %   (   %   *   .   0   )      >   %   7   *   5   A   )   (      >         %   $   2      "         .   (   *         )   0   5   %   6   "   +      5   ,   $   #   ,   1   !   1   7   p   I   4   O   @   5   3   G   /   -   0   I   >   3   4   5   3   <   /   8   =   ,   :   /   "   D   P   $   6   7   '      0   *   $   %   =   .   6   4   &   C   c   4   %   1   *   $   5   C   6   &   !   1   F   <   0   0      !   "   :   !      ,   F   9   :   A   =   /   )   "   5   2   1   0   /   O      "   B   )   +   /   :        + „¬
­
è
<5HI)�(¡Ÿ4ÿ «¬äŒfáÎÏë™GHj‹ox(4)f)Œ)°)z,¤.M03 2 ƒ§…Ž¨®
é
iJ) 5¥#1­å=¶ÐÜèxìš‹6S E!c"î"”#$—%¥%g)�)±)®*X.¥.N0 HOÍÓ´	=ß€�5ŒƒŒ°©ŸpI ¥#$($ï%&Ë'y(e,2 —eû8	|°6ù*�¢óƒS}gâæýãÄ*áIkœê1  "ô"!#=#€#�&´&‘'Ò'æ'þ'&(”()5)€)ö*{,I/30H ÕyJ.	@vyˆ‹–[š�»ÍÐ*>EÉä¡æm¦²íðŠ>z†žªõ‚·JPÑ@âú!3iŒûêT–¢¯°ö÷ ‡!F"d"#¦%&é&(q()-Æ.> 3 ^ u „¨†®[	�	+'çöÚ‹Í2Ã›7¬úTt›ŸÃ#G¼7KpºT ’ · !v!="¨"•#$Ø%O&)¼)á)g*¯*ä+u,B.”.á.£/O0C &K�©hwª½‹	ž	.
K
¯
Õ
ê
ŽK€%]ƒ¶Uv�æjsû7DŸéyíz\„èá` (!F!g#ü%t&Ù&)I)h)ˆ)Ž)²)”*m+D,×, -�.¦.Í.v0< ÈàD‘°Þ
ó
jôWSk¤ÂÄëÿH¶é6[d‚ $®ÿï[ô Ýs?íÓ-> … ç Œ!ò!K"O"‚"À"ê"ï"´#˜%I*3.Y.n0# €e	I	™
>•àÙç5qŸ§oä6÷ú¬Oó– "ã'(z(8*Þ*‡+�+,�-°. Ç¶Â£	t
�óëqJ Ã#&—)Ñ*'+A+f+|+Ã+ð+,/-( 8IPWöÎÓ!4Ôý	µ	/[¾×ù±)þ6�¯» Š¦#$)$è$ð%ƒ'Ì'ô'?)Ÿ),t-Y0- ÀõÀï/<	ª=êÑ
ÙŽLW…uç(©bþ„�£±ÇªÀG”Û þ!%"‹"0#Ò#ä*f,5-Ý.= / ³Òñç9	ØíU¬Úú–7ŒôŸãú¢Æ2‰µ$‹ºJ[gp�A‡ï!û!†"`#�#®$ö$œ%µ%š&ž&Ö&Ù'ÿ''(})ú);*Z*·*„+R.A/B 5$u˜w|ÁÚèí¦Î	5
3±¾Ÿ­BÈA£„~hëWäÅpâl$R™ ’"¬"#v#›#­#g%o%‡%¸%à%�&8'Ó'ç'6)Y+ÿ+-$-¦-ç./4 Y“xõûrºË+õw’ûR™ÐÙçþ\+�¥’§ËpÄ–ëu2 ¼ r"õ""#>#ˆ#’'•(,)_)�)*÷*«+J/É/1 |šÃ¶fôüÂ
È
]}!7	Œ‘”­¦8TÞ› ÉM#Tð×!¡"Ä"„#h&x&µ&'À'Ä')Ñ)Ü)î) +|,Í-°/40F ¾)ùw‰Œ¼F”Q›Îéô<?FÇâå�‰çkt€ž°ëîñ‹hqx{€ƒß	m5&"4ëéü …®õ Š!í!}"‰"#^#	&�'v(6*z+-å.K0B ’£œéðAPË—âýêP\¼gpÊ0n§$3?f«ÀÝX¸Q�¥½ÉÒ¿
jÖ!–,U—šò9 ˆ!"â#§%ê&^''-- -.$0,0" {Ð;žK/	€	ñ	�zžQüA6®º!G"È"î#$S&6+�+ë+Œ-³.Ç.> ?Öãz›Ñ+f¢³	K¢»‡ŸöïKÙãûdŽ ô	*�ë£éw›°±÷ø Å!5"e"*#N#:$©%'&ì&'(r()É)*v+µ,.~/90z , k�”ü”In¡ #&,P¡Ë(X”Íèë·Òÿò4Rp¾Ü÷ir2tŒ§ªÎõI»ß3H–áöPYnÂ4Ž”Är�œü8­ûp‚¸ÁÐß'9<u–Øùadsvy|—š »¾Ä$~™´·½àLÁ' “ !w!©"#Ù%P&x'h*°*˜+µ+Ô+M,-â.+ 4 v ‹©ÑöEm”óÉ¯�	Î8Fq»U � ¸ !•!D$õ%\&
'H(�()½)>*å+<,©,À,í,-�-.6/2 _ ,EO…Üy¥É‡Pœ4	Î+A¹pA¼Ú¬Z€V˜
:gÊ $¤$q'%)ª)†,—-¢-C.H.{.•.¤/Ã/- n Ü ;­²R\	™äãsÛ#ZÆ&\­a—HÞÂUlœº³HW`Ì!>"–#Ü%T(Á)â)+¸+v,P0r0D L�'*¤§«ÎÝë		ˆ	Œ	¯	¾	Ë	/
2
†
Ò
	RaxÁ·©ÑOv5k8‘EU0;{ÐN…ÓOœ‚�æÉ ä -!G!Î%ý% &u&‰&1'‰)!-Ú.03  fnñ¤ÍÖ¾¾Ÿ	%
�þ�Õ^VwŽäüqË]ÊéÔjë ± 2!h#$�%'5()J)i)³)S*•*‚.Î.Z/0w0< '0K h®¶iL
Ö
ë
 Cb*ìµuøoç6 Sêô/6R©âa )!ä#&Ú&±(¸(Î(Ý(ä(ó(ú(n+1,¤,Ø,<-	.^/k/&0I A �ã 1ªFx·*	˜	
°
YƒºÙBLêH’™
&^hl„ÏAL¬9t•¸!fºö>’§ÔzîE#Gá<œ$ &7&`'¶'‹(�)ú+E,P,X,)-%.§.E0= [ 5Ä8tÞ¥å
Šò_¹�²TuÃ‰ÅÌ6 Ó¿ËQ°.^Ôú{ŽÄ!>!J!Ð!L"P"ƒ"Á"ë" #™%U'à'z)*)*k,�-.¶/o0: 9 »ÉÙEO^ú
KçXgl îeƒŽÔ%yD\õ^ŒÞ"\’î~ÕM.¶?Žý† Õ �!Û!ó!"#&÷&E*F+4.Z.s/ï/.0]0$ } áa×±kõI{kê\¾@¯;=”!.tÜ2ô; ¼"ð"µ#é#¼%'J*K+B-“-À-' ð’Qß
ô
{¥+ìº}·Å 7¡ðGðò@
8ã¡* è e!S"Í"I#c%k'*(Â(„*+// sÐ-f			²	I
†òØè´ý¨íåÚž³!­P’¸ßô— Ù ÿ &!I"€".#£#Ð'ä')G)9*µ*›+ž+,s,®.W0% Y îÕá%	�áÚr{ ô	p3Ý7¸EøL0é0!$5&À(#)Ç)}-Ž-ž-.±. ›ø p%+x�ƒ	J	e	g	i	š
ØgûÑ" $5$Ð$%{(ß*û* �çùLú6ô…?–|6þ‰å!R#	(§(s*ý*ˆ+0 á /M1	CŠ $&Y&N'(Î*á*�+ñ+, Ew…K A!^$±%&A&d(˜)ç)(+B+g+ü,µ./è/0 µÈÒ}ÃL	a	¤	
¾
wé´ý‘N$R$X$Ò*}+½+Ä+0-Ú/) Š;o·EVó	u
S�Ð„žU‚ŠMSôÎQØÿh…WnÎìr0"Ó"Ä#�$º$%Ö(ì(É.* k Î­rÅ"5Ëþ	¬	’
0u\¿dú.°¼Ad7$Ú$"%®%&+&¹&„'»'Í'õ'ˆ(…)ô)í+ /À/Z0! Ob·Q+÷-—{	œ
Ø‰ˆn‘D±$Ò$é$ù$%È%Q' )Û+�,u-ü-,.–0@   # ¼ Æ ê 9EQ�êJX©'zÀÏÔüWÕ;	‚	¶	
z
•
*@-¡#‹§#ð#*$5%ñ%U&…&”&('}(	)@)ý)]*,#,ö,­-œ.û.0/¹/â/ó/A0: ³  uêAc�@õ	$	¤ã0oª ©¿š#wÇ¨²ÿ7Ž8ý	|ÇÃ !z!	$$Æ&ð&<'Ÿ(*Ú*è*+’+-Å-û/- }Áö5]b…¾£ =	ƒ
¶¯>¿m‘ëX†èGŽ¤ÈÁ -w"Œ"Ê"1#å*Þ.b/$  <Zk	|¨>ÃÒÚ-+v„öC²ý/v "&"7#Ü#Ý$ä$-%Ÿ%p&2*i-Þ-ó. Á=0ÕÑ]›mŽ=H¿ÚÒ ! !Ÿ!¼!ÿ!]"×"%%'1+g,6- /)  â^ŒÂð«Ã-�M)ªÊ®cÿ…Üi«Ö°•Ü Y"#Î#Ó#Ç$%“%¡&ß&X'ø'(œ*8+G-< 0 ´ÓØò:Ñ	Æ
ë�å¢�ý¤Áäûâ3RŠxRYh�®Áºøˆð!ü!a"ž"è"t#~#‚#£%¶%&›&×&¾'ò' ()2)=)~)•)…+,®/3 PlOîV_µû—çeMXÄdâk£ÇðZ¶%ŒT|K\qžMÈh¯ ‡"((t(¶(Ì(â(ø(<*x+:-.#.X/|/ ì[`Îè?¦­ÖÛClB�,#P#¯$÷$+%�%)&Ÿ&î&(�(ò)û)[*³*% |Ù
"Û8õûµ 1°ýA»1ÜÞôög"T#a#Ú'((u*¸*+Ê+7,.S.d.B/J —¡äéNXqÛî¢Õ	<
?
¥
$=~_CFúB¤Ýâ*iíM³¹¾3Måq“ãöü,�m9Y�:"C"®#h%ˆ%¹%‘&9'¹)Z+]+s++,.,9,-U.«.ì/>0% K™²®¤¿_iXlÆå%µàÛ"!a!±"Ë$%á%a&Ô'è'�(Ë)Ö) ,',Æ,%-§-L./0, 6ü}ÂÈàÁ	Ï	Ø	6
4¿0 …½3sŠ³ú “"V#w#œ#<$&(7)*·,³-î-f.½.è.D/˜/( ‰ %vxé~§ö—É0A·¡*ìwôð\²Sùš M!"!"­"#Z#�#p%ÿ*e/b0E ÿ2ˆ»8EHyöslóN\±:}ÓÖ-h‹ül´Í‰¶øµÚñcåèf~ˆ�¢ÿ“ÃQx’!#4#?#{#±#é%.&a(…(‚)÷)Ë*ó*ø*+Ñ+,).™.;0& N AZ;lB
e
ü6»Çx4�÷Ù],×q—ì(v3 o ½ i"Ñ%g'M(–(Š+¬+"/' f   Î ä ìƒÒ0¯îùp
­²“ $Sÿ‚Ææ ##‰#€&¼&I'“'î'-)`)�*º*Ö.K/N H S º¥¶(¾”æ	‰
Ì
Ûîx�Ì ,böûIßý8GàåšÑÅ¦èŠñaÓÿN¦ÛC¨Ì'4Åëys"ö"ý"c#/$\%k%Â%Ð&Ü'v)	*,*k*w*Å*ì*Ì+ô+n,Ú-Ê/¥0- ·2åB»šñÃ
É
~ö²Õ�ß«Ní�D‹Ò Ø!â!ø!7"z"�"Å"…#À#«%ì%¶&‡'Á'Å'È'(n()ï)Š*ó,1  #gt‡Ac8W´Æ)®§ÕU¢°Bcœ
ƒU‘k¤_¦ ç!á"J%Q%U%i&ª&!(Ò)Ý)S+`+×+Î-Ò-`.÷.+/50+ ‚ ‡'‹õ[
^ÂÝ
%’,·} L¡Ê$’âñT…Ì ˜"¶"¼#1&y&Œ&!'4'Š'©( *+¡+.±/. }›Äû>ýØV
¨
˜"î2�•Å9Í²h–æ½¥#j Ç!Ó!¢"B#m#É#Ø#‹%¦&'{')r)*+},o/€/†0* –GNúÌ4GÞ ò‚ªãR|àâçÃ)˜àŠ›né0 H D! #$$'$
&%(w(“(¯)W.L0e %Çß¼�	Ý
ò
*&?xŠ�•Rj$Z™œÏêõ=DG\‚ÈãŠåèTZlu�Ÿ±ìï‰Œiry…�ô6�šž6Où?rá2>sìú¡ç=Jo¯„ ‘ ¶ ö u!‹!<"E"N&s&è&»)à)H*l+C,Ö,--2.A.€.Å.. ¿µÁ¢	.”©Z½æ4pÐØòžøKV„nt°(ý'º5aêý¢Æ¿N• ~"Š"ç$‚'7*Ð*ã*{+s-7 . 4{™ÂXðúq«¹Êô6A@¬˜Øù
[#‘foï†t» î!«"#_#†%´%g&'Ø'+)^)Ð)Û)í)*Y*ƒ+-Ì-æ.& ‘>¢�è(ÆêJgpÞ�%Øè­š‰!)#¨%&&R&ë&€'5*u+�+ê+ä.#080m +DŽ“¬õD¤“ÈòÈO3	"%O ÊÍ*“Ìê˜ãþ¸Qr½hq"1¦©ôo•à%@OX[¬»ÁÙ`�–Yûo�ÀÏ;k•×ø—cux{–™º½V_˜³¶Í~ÉßEÀ & Œ !Ë!C$Û%[&w'©)À)´+·+;,L,¨,-€-¡-5/B emð£½Žâ0E£ê)	‡	Ñ
BQý‘ë]Àkt÷K¨4”� 5¹:R‘¦Ó".;5›Ó�œ È ã ã#$›$'_'R*0,O,(-]/%0& º`sÝN]¤ñ€ËÄ½5ïF‹¾Ê!--âóÃ) : 
!d!"»%T'j'E+¿-.î/-0 ræKš÷Ôwý ‘ÞØ %!H"š+r,|-�-­.& ´‰Ñ:nL0	ò	

RŽÏ�TRvPþg„V³ÍüB‰ $M$Ž$¹$%@&M'¼+´.È.. " » ÍNP¶é¨Ÿ–z	�	£/Ÿ¨Æ§7,y!ï#$Ù$!%T&„&“&;'P')Ù*‘+Ú+ì+-¬-ú.ò/@0# á]|<{Ô=lÂ\,*lƒFBÉ~Û¯Ù  ž!»!É"#ã$’%'1*7+ÿ.: ëOZk×{>ê	œ^üú´L£À¯QYÚüw@QXœ­À¹Ûf"ç"+#O#*%¢%(&í&(s(œ(µ(Ë(á(÷()<)”)²*w+,.c.W/7 –JWp×	>
–Eù@£Üá
)¼ )Lõû
+vŽó8r[œ±²Úøù !! "�#;$&Ê)Õ)*\+r+*,-,¶,—/ë/K G M R e Ÿ Í ã þ1@ÑA
DíkwŒò[aHÒÞ,gßäkØˆµÄ÷¥´ðb‰ð`ÒäMe�¡ÚþB&wêxŸ'n °#[%j%è%L(„(j*Ä*ò*ó+:0& †&ä™U
§
$±Ž|•å‚ì€¤Æ!6"»#P%T%Š%ª% 'z'( ()q)+_+Ö+ò,Ñ-ö./d - zW•Æ´Ü
ñ
-“¨Y¸ió5Y[ñ3o«ÏäSY×ˆ—â÷Q„œ5J×øs�¯'Záü>q¹Âà(1=—ß`ùe¡Åš¾è <IMns/ G ƒ � ” µ º C!t!ª"$³%f&'×'$(’(*)Ï)Ú)ì)B,-r-1.c Cdl��«ô’ñ¢†	!$'NŸÉÌ)’é ·q¿js!¨ÃóöJ¼é4IßZo_Œ�•ú9Š n€Î×:çbtwz•˜¹¼^²µ4ÈÒá€›¿Â  ( Ç â !	!c!(#B$Ú%Q&¿)Q*D+¶+é+K,N,'-ã./ ÌàMqJÓ	
Q¢Î.Ó<S§ÁukÅO‚ýEfƒÈU²Ì}Úû+Ý$!x!#Ø$ %?&0*™+{-«-H F L Q d •ýÐjo•ìjZ°Ýø?�Ûà(Ã³(aˆ®P_ÑLvÙú?u�òP›¬¿%¸qÙ !"Ž#)%ç%y'(K(ƒ()p)i*±*ñ*Õ+),ñ,V/ê/3 yŒªßpÅÒžÖ‡”¸*Ñçÿ;Hmrš¾Ø . F ‚ � ´ ¹ á !!e&'Ö'J(‘()o)¾)Î)Ù)ë)P*è+A,ð,ª-0.Q SxÒÞ÷Rno$%&•›ÃÍÛÜùúûüÏÔ9:G¼½� Ž !!`$q$�$‡$”$Á$Â$	%
%t%c&d&'¡'¢'£'¤'¥'¦'§'¨'±'I(l)m)n)Í)Ø)é)ê)"*#*æ+ç+=,>,?,@,ª,«,î,ï,-l-m-©-ä-/.Ñ.) FS'®�ÄÎÝæôÊJ™°‘	,Õì[¢ –!«!a$r$ˆ$•$u%Ê&©'$*¼,n-‚-å-.Ò.ì.’/j0Ž0+  ' 5 w TÓøk–œâý.\@	
Ðâ:V E$‚$Ã$%ö%]&ú&'²'?*,,¬,Á,	-÷-=.7/z0¡0 -¯T Ë£-q½Ût­[Ÿ‡\£ ý#Í$%Š,½,þ,£-I.–.Ó.0k04  � P±GTz}‘”&µÅÊÏçGKê±5	’	
·
[™'yÃÖË M ú#b$n$@%.(š)‡,ß,Q-o-.n.�.Ä/�0ž02 ` F›Ý(ÌeŽ¸ÞõQq�U	
BaÁ�F]h|·í€$s$z$¥$©$´$ñ$ü$0%ª'1(D(P(–,ž,È,^-7.í.¥/& < q†×‚¦šˆÏ,¦ºãBW†;PQ!—!¬!‰$–$v%Ë&r'&)«)%*�,ƒ-˜-æ-D.|.“/ª/$ 6 r ù/AMt
c)hßÃm�ñI*Í!³"F#Ä$%Ý%&^&Ã&'³'¶)w,/s0¢0/  o U®Ô³Üã
´°ä'®GI¾xVr€Ñ§üîC X%÷%K&û&þ&U(Â)i+¹+,K-É->.k./8/Ð/0% ( x ø hl—�þo]A	]	o6¦Ü]˜»ÚXãK)"—#ì$ã%C&G&f(M)*+¥+­,Â,
-;/. Ý <KSjŠë	Rˆšå„a$É[ÇbÎ´a;ÌW !"?"F$ƒ$ê'ã)@*+<+,’,š,V-ó-ø-N.·.Q0{0$ ¥¾Uô‘¨¬‰	�	Ì	3
À
Ó
SÂP6Ü øÑ�ªžñå v&˜&Š)"-¤-Û.Ç/l03 .i°´(¥	É	0

(y¸.‡rªÒÝwl¾9’FV\Ñ<~çPŒ˜§H!Ã!ž#þ%!&o'¾,ÿ,Š-ÿ/0( þ+É	c	ª	°	
G
byçëu1¶†Ôuƒç.!þ#3$P$Î$%Æ%&Å)+‹,./ž/æ/0( !ÌMïÏÞì¿	Ó	ä	:
‡
¤g®Ë|Oˆ]ƒ¤ Ê ö!X#k#y#Ï%Š&2'e'±-J.—.».Ô.`0   ²ÀH‡^ÆLÊ”¿x	 	\ËÙ%$)*Â*-[/; QoòUÎ	"{€’¬$¶ÁËÐH 


�ÿ‚_WrÌ^([zêkì² r!ø#û#$@$o$'¯'/(B(K)j)´)N*ˆ,p-Ï.ê.�/Î/x0Ÿ0=   g£¾¥×1ce~•ª"¿ëíŽ²â“	Ã	Ñ	â	&
8
E
Öx�¿åýšY×Ì N 3!p!i#>$A%C%6(8(:(<(Ñ,å,o.ƒ.Ž/Å/00�0$ Ž · 
_'èŠÅä6	n	¦	Å	(
a
¸
qÏ÷»ÄÕ c$‚%X(›)T*–*à,R-.Ž.R/ˆ/f0' L!Íižý
fÕ³†ù†0AT'ÿ7“ï eã6 g ¬ *!&(2(E(Q(
./_/l/ø/8 a (1)7�ßönR	ý	
×
ì
+ íP�ÿÂ{õISi}ª¸î$¦$¾$Õ$%%™(²(È(Þ(ô(9)o+2,—,¥,Ù,[-Õ-8.v/Ü/E • Ô GŸ·È3gÔ2Cfw�£±¹
¯·åjrN	V	
M
h
l
D;Cb¡‚ë0 ^”¿~!ƒ!å#T$Z$t$1%Û&-'«'¹(Ï(å(û(¿+É,ç,_-µ-q.„/¦/	0'0/  ^œÞ|R� 	Þ	ÁcØ¶vp„è.7GŸ‹�b {$ª$µ$ò$ý$Ô%>(Ÿ,Í,=-ÿ-.….î.™0< 8éÊÙä«G´+	•	Z»-Cë“äm	±­Á*u ?ºÕeÞâ5=ñQ	yµP À ü ""•":#&*.+P+²,2-&.E.¨.F/y/«/= ’ Ê e«—§„Æš!i­ÐMÜC¹"y»÷“ïF$‡œVÎ7b ~ © ˜!k$w%�%8&')¬)*¹,Ó,Ü,N-x-„-á-ç-ð-h.}.¿.Â./”/ 09 = Xr‡ØUYƒïs�y¸r	™	Ú	ù	 
Ð2§ÚáMI»'_#BÉX£ +r 5!­!±!&·'Œ(�)Ô*Æ+F,Y,‚,//05  B §.?Ä›!2‰±
6¢s¾É7…z:‘–g¨{H<`R!Z!Þ!l"Š$—$�$E%l&Ì&a's'X)£)#+û+Q,*-™-š/F0’01 \ s 6ÅBuzë
I¦æ
:óuŠÆËÕBÄÌ‡n#"M"„"Â"ì"’#š%Þ%ú%á'ü'{)�)©+x,Ë.10t0> 7 úw9š~	ã
ø
‹N`™ºÉ×svðÍOd?i7t¹S.ÀòžÔò±*_|Ñ´¬ûó Î!Q"º"G#\#&'´'*+I+‘-.p0  W ßXa‚�,ûJl�+ÅÐ!!?!Õ"¡#Å$%Ä&V'¥(¾(Ô(ê( )E)·/- 0¹c
ÿ ³0U Ä{2Ó*ÃKb±¼ÔàR/ÕàÆK!�!Ñ!œ"¯"´"û"_&·)**É*5,l,Ø-!. /„0£0' ¹ ´ÝçæèoûZz(î�#W“×@� ‡ Ö #Y%„%$&L&ÿ&\)§)F*j+�+º+Ê-?.ð/N : p ‹ ¯Õ�ÊÚäˆ
Ú
ï
L‘Yh†W¥ïafÕ&EH]Ôö_­¿%ß]/ïpsØðN\ùÒ(ýYD   O!©!">%r%Á&ø&ü&( *,�,T-5.;.l.9/T/h0, � Ò Vç/a¼=qŒÇp	¨	Ç	û
±&o„„‚(y�½^¨ïÜ!ô!"¼$%V(Ã)L-/t/0^0d0$  ®?FP[€‚„†G_µmå�ö¯JÖî/·þŽ!#9%ø%G+¯+[.Ñ//0  ) °Ú8	^	»	w
œ/u›13;!½"ñ"˜#'V+c+Ã,”-].ß/% Œb˜Øÿ^B	lŒlëÐ™%L"ÑÛöYÝä	W!"‘$à$ä%D&H&Z(g(N)K*++¦+±+( ~ ù iAm)²
pø*
Ÿ
º
7J|ÝUî]¿A•j¼ÐLõ2< y *"¶#e$½%;&](j(L+Á-% y 'râžUpö™§C‘•°^<>s–¥Y]¹Ã  
 ê#í$}%ä&C'Ø(®,-C-ê-</* Þ xª%‡·çb~Ê!¢ø\ñc`óy ãDtê!2"@"Î"Æ#ß#d%Ë%ô&ë'ä)‘*+,b,-ù-O.. ,HLT‹à
õ
ÆÞ‰Æ<HñSÅÈµtäÍ+ !›!À!""ä"„$;%M%z%l'+(V*,“,›,â,‡-ô-¸./0 =k©ÙRaE	ì	õ	9æ|…¦í%¸8ÈÊÓÏÚAÅµ9bUX œ f!T"#Ã(˜*Þ+W-w.�.%/g/|0)  ñê“R]Ÿ�
ÒS›,P»£|«òË<G¢¨é ï #J#G$­&î(Q)A*…*+=+Š/Ó/R0 ‚¦ƒ�7	³	h{¯(ž3þ‹Ûwêž5ó"¤#Ñ'å'‹)õ*> �¯gv©­Z	Š	Ž	-
J
Ô
u‡óºÃµÙµcþ©îúóù h[Òé",S•®Ÿ¹àõæ  !'!†!J"�"§"¿"#³#))H)‡)f*t,“.¢/m0% ¿VõÒ .3dü
		H	s
˜
<Øéæ®ö«“òÚ /#e+œ+Â+ï+,,.-¯.Ü.X07 #t²Ñ’Í	4
Á
2w×T ‹QÏ7ÝžVš¡1Ÿ´€Š¤ÈL#@•Q˜ q"š#¬#w&�&™&7'ù):*¶*X+Ÿ+#-¥-/@/È/* Ïâð	øPó;/ˆûs¡#2¿ÜîW4¾)•è™ñ8 Ä!$9$'È)5+~-‹-Ÿ-.².+05 + m Û NjŠÐlH± â3ÛsHºÞGõ
m3“«Gq€ÝÞ8¹9f”!#ô%p'G(S(�($)—+Ó+…,¿,ì, -–-z.Â/A  @ /JÕgµ&)¦ÍÜ		®	½	Ê	
$
1
ÿ
‚)AéÔ	«np·eõ=DFMQ¨åê,!1!ÿ%&6&ˆ&0'4(Š(°(ò(ù+W,£,.Ù.j/ 00D0) Z 4ïØÖJ^fz*ˆz¹j|�Óx:C]Ò¯ùzÛ�1=!I!Ÿ#è#"&Á(*j,�-/\0( ùÿ*$,€‚„ 			d	f	h	±	H
zˆüì2Ù�²·è/!ÿ#$4$Ï$%4&Ï'Æ)ú*ü*0V0 .U|K	`	½
LÍèv„Ò"Q$W$]$°%&X&c(Í*à*€+û,/Ù/ç/0> Å Dœ*qt&,y¿ûVÊô:	«	
y
‘
”
›
tâcn©¾™v‡@c6$Ñ$%4%Ç%&º'|(‡(„)~*",Œ,Ä-+.›.//Ÿ/á/ú/  ‹;„½ÿj	‚
µÂ¾Ðš<hÕü.u 6#Ü$$%Þ&÷'(›*a/ ÍNÐä¥0LŽg® `"S#}#½'ñ'
(1)t*+É+9-.%  ãèMûÇõßÀ	Ô	;
¤
<}^/h¶ì¸’‰X"Y#€(þ*&,Å,²-K.¼.0=0a0$ ‚µ7:kíå	o
ˆ
G5Õ7ÿŠç}ÂÅ3P#z#Á%Ð%-&&»&f'`(ö)‰+Ð+˜.Õ.2 � ú"Šs×ð†Z
@—Áõ³(¯Ì	KªC£"^„Ši ¥ Ë Ñ æ!÷!A#l#¿#×#I%ë%0&‹&¥&3'†'m(¨(‰*_.*/n/ 3ÁFMùË»Àœ	¡	ÉŸæ$&$*Ï*â*‚+-" *ï=C¡¹_¼ÇMá/DN(	2	Ð
¬Ì}™D‹ Z&S'i'³+§,\/ ! ³\ˆö9m§•y	$L$â$ƒ&L'O')þ. ž â 0I…=˜T
]ùÚ&(›(´(Ê(à(ö(;)“)Ã*q+ò+,. P c cËóVÏ‘ð…	‘ ->nÚRXƒ‹'N=OK_øÙ±3pB!s!$A$×$%(%²%æ%>&C+q-é/( & RQ#j­ÄŒšÂÌÑÚáø-I
)ël³ _$p$€$“$À$%'°'k)è)O*..Ð.ë.‘/y0�0 0* p
|�“%Sd´·FpT	

¢s\x{†ÂOL ù#ü#y$¨$³$û$0(C(O(™)‰,ý,]-Œ.©/�0 ÷ @nê	nƒ	`Íwíë$&B&F&J&e(L)µ))+h+¤+™,¶./Ï/0 h¤î~b	Ò	ã	
9
F
¿
xæê}÷µ—¦j#O$—&~+°-Æ/å/)  ¢½¿	!^d†«!#]ÀìÄã¥	Ä	ÿ	
'
D
ZºØo!q!$$?$B%®'7(9(;(M*‡/�/00 ¶2fÓ6v{€¢°äm�M	Q	Ý	ü	
g
k
×þŠþ“’î5 S$Y$Ô$%Ó%,'=(˜(Ç(¾+Ì,æ,Z-þ-p.„.Û/÷/0˜05  É d¦ÉØTX–î³”	ø	½6y�ÀÛ›ÝUðÍ*x O q ¿ 4!Y!°!k"j$D%W)¢)Ó*"+-+O+Å+Ò,Û,1-w-x/0‘0% v¸W™}	b
þÖrŸïzŽNÂR-†Ó)ÐßkÅ›"¹"Ô"œ)¨+4,×- .Ê.6 � ¸ Ñ `Žæ<pF‹Æåo	§	Æ	Ù
î
�…Vƒ¤`õ¬$.oí[ø¼'ÖX Ÿ ¨!"#»$%8%ƒ%Œ+®+�,S-:.S/g0" q‹(	Ù7	º	)
v
ž
¹
T‹TíÏ›ir¤XÏÂ	 d$�$ã&B'Y(\(i(×(Þ/+  +éØ`D	ô	8ÅÑÝO;ÉÒÄÙ _ÄCsÊFs¿!1"Å#Ê%í(P)U*�*—*Ý+a,á,�.$/‰/ "®‚Ñ6uû	Y	,
r
—
1gvÖ´Uè "”…!)†)Á+î+/¡/5 l Ú IMÏkÔGÎ×ŸÌ­	ï	
#
þ
]e‡ú1B½(8eðä7 +!ç#8$ó%&‡&/'3(F(R(‰(¯(4+–+ø+V,ë,Ø.Á/*0C0[0, Ä -Š:Cs)¾úþ#óÿ�
“
¼
´‡û±V$\$Û$#%3%¯%&W&Ý&Î'ö'(!,Ã-`/Ø/ù/0$ € ´jrÆÖn
À/BKW�¢!fh ­ À%,&º&…'¼'ð'_(l((0)õ)%,.)/m/# � )2î< ¸õ8ELl„¦»ø.S
«$K$‚&K'R'š(³(É(ß(õ(:)p+¦,ý.°0, % b ö bÊPiR�³àï÷,oS	„	,¡ÙQ‚ ŠJ2o~ÁN§$²$¿$Ö$ê$ú$%%=&˜,\--.¨/Œ01 È ¡¼c S]í5\z¯ãlP	þ	

j
|ö‰T’–¥¹ïÓ$%–&+'­'Æ(¡)!+N+Ë,Ú,v-¯-ý-w/†/ä/ö/0—0!  Ð *p˜Ø|	¹	�
Ø
í
îÁÃ,Bj&E7%É%�*Ü+3,Ž,Ö-9.Ý/1 Ã 
H‰9FÖ(�½ÐÕýtòX	
m
€
–
!Œ„!æ#U$[$2%¿%ò%V&†&Ü&.'~(®()/)À+ ,$,U,ê,(/)0B07  $ Ç õ  É;R\hoŸìô4DK[kyƒ¥®²ºîâk×O	ƒ	¸	
R
i
+A•¤À%6%•&*'¬'Ê,®-ü.…/§/ã/õ/0‹0p ¢ £ ¤ ¥ ½ ¾ ¿ À Á Â Õ ë ó ô 	:…†‡ˆ45678žÕëòó	
3YZghijx‚¤ª«¬­¸¹º»¼ÜsÖðñW	·	

N
O
P
Q

E¢£$÷> )'•'–'›'œ'¬(­(
))þ)ÿ),,,,\,è,é,r.�.ž.ô/
00(00Š0©0I – ¦ Ö æ ì û ¸2c{°ÁÝæX<	{
Fg<DT~•c¢ƒì1È._gø? !¨#ñ#+$u$$'�'—'�'º(Ð(æ(ü(A) *^*£*¼*],÷,`-¶-º-s.Ÿ.1/º/€0ª04 h ° ç ‘-vBÂö!	äª‘Ee¯ß›Î UÈ³í�aÒ
h‚^!,$«$ó$Õ%%'Ž'«*Û*é*á+.O ´ @[uÛ+±±çY‘	=	u	ß	^
¥1p9ª WÀð&dq…|—‡ ¨Éþù4}Õ@ { Ä !{!€!%#‹#¸#¶$þ$¾&Ç&ñ&ž'?(»(Ñ(ç(ý(B)+Î,Æ- .t.2/ü/�0@ — š § ª ­ × í ð _¹�}Üd|AS%	|
¡
GdhÙb¡·Lwé8©lo„ 8H9Œ/`©#ò#g$v$|&˜' (¤*½*“+^, ,ø,·-†.‰.š0«05 … ü ß¡ 38dëžÞÂk€=«U–_C$/x£„¾2Èc !i!,"
$ $|$'='b)*_*€*->-a-»- .ï.M/»/3 ~c¿w¤åH,	[¼«Ø”À&’!Y´éH§¸E‰¥ÉnÂ
Q ^ ;#e#¬$ô$m%Ö%�'¬*Ü*â+3-ß.G/G { 9’¼ÂËÚ6š¬µ–	„
Wå·D’°Ðà?Ffnnàì
~œ®Ï>vÉ;
»�bÓß6Îƒ¸!"Ë"ì#%Þ'x)'*³,F.´// i ± è ÷nÀCÃ>	"	„ðz²+!‡ŒÖ>e!.½z¶ Á ý 	"W"u"&'q*æ*/+E-g-Ü-.- ê^†.<÷a.ìL¯å›°EV²ÂËÓ@îfã�òRi_!x"�"–"2#-$&G'ê*Q+ì-'.©.c/z/¬/0 Ë ˜[2©"›Üÿ"?j—€ÄÿœD	}˜÷ˆ@6íÝ$ ¹#·$å$ÿ$�% %q&æ&­)3*×*+p,Ô,~.Ã.ô.3/•/!0I  J AvÜf²èZ>	œ¦ÇP:®áYÁâñ'ç†Ýš…¼øˆDÕÝÊªÿÏú8~Ö A  Å !"'"&#Œ#l$ï$.%È&Ÿ'().*I,º,Ý,O-j-y-Ç-â-ñ-i.> “ µ \¨,²’	l	v	à	_
Ó}q«!NÛe.,w¸cG%�¡åWþ5c| ª |!�!8#1$Ä%@(À*°,Ï,ß-.À.//Ì/ý/3 U ¬=‹
….ÑXÓ“r€`QºÒ#@z”ð[©³á0w ™!Ý#Þ$x%9&¿&ò&£(¼(Ò(è(þ(C)*Ç*-…-è-u.‚04 > ˆž‚Že1Tz¢
r3â¼Ò(¸xœ—ênìó˜I¨Ya,ˆs Ï  "^"ª#}&¸'�(Ç+Î+h,ƒ,¡,ù,7-//>/5 Vt„Âät~Š >Öß–B¹&	š	Û	è	ú	Î
Û¢M^Çªpu;Â'{À m!¦!®!½!ÿ"h$w$&%U)‘)_,Š.›03 ˜ › ¨ « ® Ø î ñ Y`sºÙ+Zða	s	!
}
ei¨�`cÌm…_¦0IÓ!'™'2+”+ö+Z,¸-‡.0§0®0< ) €˜‘ÔÝ}ÑÝHNÎÖJdÚý•$CÊê9�9:g¤>�»Û " 6! !¢!¤!²!´!¶!Ø"ó#&E'¡(y*¥*¾*Õ*G,	/¬0/ † _¢¸¬ì"3ŸÄø.h‘©|…3i€�ß!-"Z"Ï#È$%”%m&±&Í&'Ú(c)*�*�*$+ü+?-š-¡.ð.“08 C ý ¨/@§ÅXœñ7ÃJl£øtf’Ö%>¤*Ë¯<ôÅÉ d !8!ø"õ#‹$˜$b't'ù'(Y)¤)*î*9+-H-¼-›/=  àøûþ*9ÃŠß¬ß�>¿ˆ¬ÊÍ0ð8VI—»E`{;D—0Ny¨«¿Id †)Ç=[ [!j!Ô#!$}$F%¢&à&{*R,+-, !ã�!4e“Æ²
K†©:/�PÍÝj¬×±a–Ý S!m"Ú"#$ž$^%Ò&>'Y'`*m*§*b-N/¼/G0: 1 d§Ò«
ç
;øŽ'¤"0<eåüµÍ4‹Fi‚Š¯¨R b"Ÿ"í"<##“#–%¤%î%œ&³&�'Ê'ý')3)e))­*d,y,£.H/20/ ] t CÔxJI-	æV£ÁÌþÌZÂCI«SyžÂFƒ»_ ñ!N"é"f#×%û%&Ø&(p()“*ã+Ì.à.u0" 7Æôî ;	Ö	¦ã¨Fù‰ý!$"Â#Ñ#â'ó'(>)–)ž)Ý*&+@+†+,4-œ-D µv{ÀÙçìó¥æÇ
\½ìôž¬Ù•v‹Ç“‘ú¥êÅˆo¹"SZ¦ÊoÃÖ!ú!…"‘"Ã"u#ƒ#‡#­$õ$f%n%›%·%ß%Õ&¿'Ã'|)ª+þ+Q.¯/P z½:›	ŒïOš»ÊE“áüéOèfoáPe€j�¯ºewl¤¼È	c�ŸÕêó 5+Ÿv„­ô ¹!ì!"4"|"ˆ"Ç"M#]#á#í#]'~'u(*y+´,-.}/J0$ :û“ÛxQm›W¶Ñ@ñoYÅÁ~·&U²`r}	£$	'=*+.G.q06 Ì­¶—	…
X¹aØ`Gw˜g´Î@Ð8NuãÊT/óàÏÒNÉi° €%Í%&µ'·(Í(Ü(ã(ù(;-$.Y/7 8 | Ã7Pä
ù
‰æ¸±tí?<“ñ[‘P}Ô	7L]µ�üÔ Ï!Ú!R"»"Ì"H#b%ö&'ß')(y)(*D*ƒ*+J+A-’-r/µ/' X íøÏào$5ó€…ñ{×³ó×ÜDKf/·þ ä!Ð"-#Q#¢#¦(¿()")F)r*´*. à DDƒ‰×m�@!/"(Õ(ë(æ)0 j ² é a¬é@bœÄ?	#	"ˆ-ü?m�"C{ÆÂ !°$ø$­%*&¸&Å&ï&''ž(ó)ü)\*ç*+õ,û-¸/¿/•0* 4\a¢ÁY§®�,�õ­,¾Ñ !
"X"\"v"Ö"Í#Û#Æ$%,%ž%o& &W'0+F-h-Ý-ò.$ _Å
 !´¡ædWÃcájÕáïBSk{0ÇÝóõ÷�"s#&(ñ)6,".{/­/% ˆ }¡#/¾^L²½2kä2ï´ßL!`!9"B"°"U#Ê$%`&(¸)8,í-T.e.ª.C/d/= ë¹‡¤º'/®½ød
Ë
ÚÆM°ú9|3œ¬±öüF#³Ìþ‡Öå‘!h"ü"3#b#.$Ï&H'Û'í'u)+*v*Œ*¹*Ê*ë*+Ë+,m,Ù-(.!/¤0.  1=AºbÜí1VÅÔ+¶ÄÔ¡Ab±g¼�‘áSjÒ!á!y"Ž"—"µ"à"È#©&‰'Ç'*Ÿ*+R+.…06 $˜Þï%>p3ªÝ#@˜C��©óU™Næør‰�nîm;"D"#æ$…%M&r&ç&])®)º)ß)G*X*k+Õ,Ë-@.V..Ä.4 ¢rÇÜ�\£çü�Å¥”îENW“ºØ~4Ž$,”÷-:Þ% Ê!$š$º%%& 'v'¨)4*t+Ž+/,:,¾-4/í/"070& º åO™µèvœk [+)¦ØA� ˆ × �!�$¸$ %‘%’&':'Ø*»+Ù+q,-¬.ù.ñ/?0C Ì ê%NVYÖ	=
@
¦
Cév‹ñ#` DGûÞãj{×´
¤¿ïX”äýAW7vZž&m æ"¯#º#O%S%Z%i%‰%¡%Ô)+[+^+,,Ð-b.õ.–/c E K BLi³
Û
ð
M’§Èi;Yh¶X¦¯ZÀð ÂãòÖè'‡Þ›I^j²÷`®ù&DYe‰à^mÇÍÖ0T±Þ>t€ËæñO« ]úÇÜ Æ #!b!"'#�#(#(‚())/*ð*(,J,&-z-U/4  wÝå˜[?	�+Õ†“·ÓáÐæþ9Z™× - E € ¡ à !ª!†$s%b&É&ù& 'Õ'Ì)×)!*,,»,k-¨-ã-ö-<.i0% 
 ; Œ °Öš�Ëé¶
¥Zâ`ÀžE…&¶P!m$Ì$ð$%/%?%-(€,•,�,Ç,Þ,P-6.m.01 q gÛJi‰³L¯Q‡5¥bÈ(gF½ðqÙ)J¦ûËB !"("²"E#W%â%Â&ý&é';+‘,J-U-È-ò-M.j./:/* ½ýó³È©	È	'†ÜfÊÐæt‚‹©ðÂ!õ!W#x#�#2$Å%&d'n'Ä)‰-º.-/�/þ/_0$ ¶ 0b©É‰�“ám	w	Â	Ð	á	7
`
p¾ÎöX÷#=$A(W(*Á*Ð,ä,-é.Q/�/Í/e05 ” Ó ÿ ]žÇ1B		ü
eÀÔ~²:Ÿ…O…ƒ/€-@zH&ž¾df « }!‚!½$%(8)´-Ô-./u/ƒ/C ‘ 7Wèª->r~Ãq	Ù	5Å1¡àrÈ ¬"°È)x¹d¢4ÿ_6a´} ¨ û Ý!""”"9#Ž%k&*±,¸,M-à-ï-g.¾.Á.///E/™/06 V yê	H`â
÷
9˜È/Ê1ÒÔ>s¸Ja°»+Añ³«Ïúò !�!""®"ú"[#‘#ù%û'¤(½(Ó(é(ÿ(D)È* +H+00ƒ0& Š æ­.>Z�ƒ…‡nú%nY�'Óí×ï]N!#=%q%À&([)¦)*c0!  &¯@÷˜B�”$K•š\Ðõ0¸1ÿx :!V!"ß$|%:&U+b+°+é-\.1 wG©$Q\ž¨Œ
†¶æ÷¢R{Çxª´âñT§› î š!é!"ã"##Þ#:%L%y%¬&ó&
,-†-v.f/Ò/F �±�Œ2cG	z®t'~Š;~¹×�2býÎŠù�ò™0v­ég‰£ÇKZõ+R”4?p"¦"¾"ò"#™#«#²#Ž&6'ø)e*ô*W+d+,--’.?/<  * ? ‰ 3fÛ¼	I÷@èOÓ)2ò:yiGŒ¹Fm"2oª¶ÛídÜôC”®yÚ<!“!#'Ž(ñ(*Ò+i,„,¢,•-.y./i/0  )ƒ¼TU{9	_	x
�
sámÁ¨½ÏK™½˜Ìœ ;?b-t 5#3&¹'b(†(ƒ)}*š*Ì*ù*ú,*.š./à/U00 Ÿâ‰9Y
£
F4;ãô]²Ô.'µë·Jæ‘©ÁÄ2‰Ð "_"
#@#|#¾#Ö#H%ê%/&~&¤&ˆ*+È+Ï+Ä,8-^.<0 B[à<—Cº'	›	Ï
Èžøå
|˜á$h'’)²+! O Ãc‹™Ù ?mé	m=m&Mv<N÷Ø°x$$’$'%å%E&I&N(£+‹.œ0" W… u¡Ü	÷	û	C
f
¼5ÚÜí)w4 p ¾ X!n!¯!j"#$i$Ò%—(V)L*,+Y-: u�å×_C	ý7ÄÕÜy£N�_ì:ÈÑš«#^q£-ÃÒ(ZrÉÞÁW ž §!¾!"š"¸" #â&A'[(h(O)‹+§+­+`,#/!  Ù ,jÓB³qùúî	"
+
q
»
³çJV¡ï'^(k(3+•+÷+Â-×.×/0 œ Ï a»íÀ1MJ$<&�&J'Å(Ž* +M+¯0, ¡ å ò ú „[nñí1b€Ûá
ï~
fS}”Çfö= ¾%#'Œ'”'š'«(.)¢*»*T,[,¹-'/~0‰0¨0F g „ ™ © ¬ ¯ ï ?ZtÚ�*,7°Ût	]
 
j©�8adK®ÞVï%^ÍBT{ –kn†`ƒ½§Ñ3Ôz !]!h!+"$#Š#·#f${&½&'a)ª*à+ˆ.L/9 z »™;m¿V`ƒïyÏ×ßK®%šD}=±ÊÒ:‹	¦·DˆÍdm¼ ] ·!V"t"d#ë#l%~%&F'Ý'w)p*D-f-Û-ë-³/: I T Š
›ÒO!-Ûþ–àXþá’æ›_™PÑ?·bÔZÜ?©à5äìÜ# 0$î$Ã%å&¢(-*¿*Æ*Ö*H,o,¯,-
/Ë/A (*ÿsã‰Ÿ��— `ÓÕÞ~•ç	Í
qÜŽÍcü”–ËÆéëòt—:^§Áf¥&zº‡ Î l!¡!£!¥!³!µ!þ"D'T)x*Í+õ+=/¦0­0= ¦·÷úý)W’«ÅÞI÷
e‡Ì÷/Jï¨9Hº.DÕ=§� OÌ;h(ŽÆóÄ Z 7!Ù"÷"ô#]%°&Ñ&Ù(
*l*z*¦*í*/ óæíÿª
U÷�Ë£ù/;¥dª!�E‚§EÕ!ù!�"†#Á#Ð#e%•%í%²&Ô&Â'É'(o()d)’*%+?+ý+c,›-P.¢.) yˆ¸èN³’}é4OuŒÓ Ù!ë!3"{"Æ"L#à#¢$a%Ì%õ&'\'}'Û(C*‚*+-@-q/I0" ß `3«C¡#4›òˆÖòô¬ã!."["Ï"Ì#Ú#¬%n&·&!)å)
+ô,ú-ñ.¾/”05  ‡ ¸£¹&@­¼ Ä
Ê
Åùc«½"]àiaj†jzäî�³à!8"A"ß"r#Ç#É$%¨&Î&ˆ'Æ'ì't)ð)*‹*ž*+,2 #$MUÆŒuBuŠð�“¨ÖV’×òT£¥+Vul%l œ!É!å"$Œ$™$N%R%'u'Ó)Þ)W*Ø+½-Ï-a.ø.601 	 D Ihh—µ
K¤4Xgµ*Ç±Cd�ÌS°=„’¶I¥Æå˜Ê , ß !D#…$V%"(,(ï*:+,”,œ,I-õ-0 þ �Æ©0AòˆdÄß9žÇ¯Ç?ÉÏÍõ`e § Á!"ö#�%j&c'm'*ã,-ˆ-Ó-¹./,/P/‚/Œ/œ// å-¨#Y�á
ö
8mÇù$—=I&Æ™Ï¦ªÎí ñ !9!U!è!"â"ù"#<%K%{%«&ú'(Z)¥)T+a+	,O  €á(S‹bF	X
�
­à:?Àç&}‰§Î1ñ9&J˜¼1Fa¸E!Ë1©~Û¬BÆJ­À:ô*“Ù>>o"¥"	##½#Õ#G%2&�&£&5'ð(*d*|*‡*™*,-.x.‘.h/T0 ö	ÃÔ<9M¢¯ÈV� ™"·""$~$á&@'¢+X-" ƒ >�ì+6ÚÚàí	\
RzUe\!g!I$z&"'‹'ª(Ä(¡*©*+ß+S,&/Ö/}0ˆ0B þˆŒ–öùüÿ:V_lªÄÒ_š‚	Þ†­Ë.“îW¹-|<~É˜ÔOÐ¶ÀËe¶%‡ßclãò†Y \ Í k!U"¯&S)o*e-²/)  ò? þ©
TM‡ª¼:¤iè¦²Ô!Þ"K#q#Ë#Ù#¡$`%§&Ó&['|' )s)B*	++>+p/½/H0+ "œÅä"g–´
#�ï3Ž–Æ‘Î˜RÎÌH$—¥©k Þ ì ð T!È!#C#$Œ%'~,O/�/‹// Žýë•5U^ÑÙW
Ž
™Ó-Q;0}µ¬¿Þók®Ø=dn"¤"#H$®&?'ï(R)*c*n*†*¨*d-Õ/S0‡0: ~ü”STf”•ÇÈÉÊËÌÍÎÏÐ³
œL³´—Qç¾­bc£¤ê ë £"Û"Ü"Ý"n#o#p#Ê#Ÿ$ $_%Z')***a*b*+++c-Ô/  =¤  qGACNNNNNNGTC,CCAGGCCTGG,GATCCGGATC,CCWGGTACCWGG,CCANNNNNTGG,CCAGGNNNTGG,CCANNNCCTGG,CCAGGNCCTGG,GCACNNNAACGTTNNNGTGC,CACNNNGTG,CCNNNNNNNGG,AACNAACRYGTGCGTGC,GCACGCACRYGTTNGTT,GCACNAACRYGTTNGTGC,AACGCACRYGTGCGTT,GACNNNNNGTC,GAANNNNNNNTTGG,CCAANNNNNNNTTC,CACNNNNGTG,AACACNNNNGTGC,GCACNNNNGTGTT,GCANNNNNNTGC,GAACNNNNNNTCC,GGANNNNNNGTTC,CAGNNNCTG,CCAGGNNCTG,CAGNNCCTGG,CCWGGGCCC,GGGCCCWGG,CCWGGGCCCWGG,AACNNNNNNGTGCACNNNNNNGTT,GACNNNGTC,GAANNNNTTC,CCWGGTACC,GGTACCWGG,CCWGGWCCWGG,ACNNNNGTAYC,GRTACNNNNGT,CCWGGYRCCWGG,GAAGNNNNNNTAC,GTANNNNNNCTTC,AACGGCNNNGTGC,GCACNNNGCCGTT,GCACGGCNNNGTT,AACNNNGCCGTGC,CGANNNNNNTGC,GCANNNNNNTCG,CGATCNNNNTGC,GCANNNNGATCG,TGANNNNNNTCA,TGATCNNNNTCA,TGANNNNGATCA,TGATCNNGATCA,AACCTGCNNGTGC,GCACNNGCAGGTT,GCACCTGCNNGTT,AACNNGCAGGTGC,GCCNNNNNGGC,AACNNNNNNGTGCMC,GKGCACNNNNNNGTT,CCWGGNCCWGG,AACTGGGNNGTGC,GCACNNCCCAGTT,GCACTGGGNNGTT,AACNNCCCAGTGC,GACNNNNGTC,GAGNNNNNCTC,CCWGGTCTC,GAGACCWGG,GATNNNNATC,GATCNNNATC,GATNNNGATC,GATCNNGATC,CCWGGCGCCWGG,ACNNNNNCTCC,GGAGNNNNNGT,AACNNNNNNGTGCAG,CTGCACNNNNNNGTT,GATCATGATC,CCWGGNNCCWGG,AACTGGNNNGTGC,GCACNNNCCAGTT,GCACTGGNNNGTT,AACNNNCCAGTGC,AACNAACCGGTGCGTGC,GCACGCACCGGTTNGTT,GCACNAACCGGTTNGTGC,AACGCACCGGTGCGTT,GCANNNNNTGC,GCACNNNNNNGTTCGAACNNNNNNGTGC,CCTNNNNNAGG,GCNNNNNNNGC,CCANNNNNNTGG,CCAGGNNCCTGG,CCTGGCCAGG,CAANNNNNGTGG,CCACNNNNNTTG,TTTAAACNNNNNNGTGC,GCACNNNNNNGTTTAAA,GCACNNNNNNGTTTAAACNNNNNNGTGC,CCAGGNCCY,RGGNCCTGG,CCWGGGNCCTGG,CCAGGNCCCWGG,AAGNNNNNCTT,GAYNNNNNVTC,GABNNNNNRTC,GAYNNNNNRTC,GATCNNNNVTC,GABNNNNGATC,GAYNNNNGATC,GATCNNNNRTC,GATCNNNGATC,GTYAACNNNNNNGTGC,GCACNNNNNNGTTRAC,GCACNNNNNNGTTAACNNNNNNGTGC,GATCNGATC,TAACTATAACGGTCCTAAGGTAGCGA,TCGCTACCTTAGGACCGTTATAGTTA,CTCTCTTAAGGTAGC,GCTACCTTAAGAGAG,TAGGGATAACAGGGTAAT,ATTACCCTGTTATCCCTA,GTTAACNNNNNNGTGC,GCACNNNNNNGTTAAC,AACNAACGCGTGCGTGC,GCACGCACGCGTTNGTT,GCACNAACGCGTTNGTGC,AACGCACGCGTGCGTT,TCCAACNNNNNNGTGC,GCACNNNNNNGTTGGA,CAYNNNNRTG,AACAYNNNNGTGC,GCACNNNNRTGTT,GTTTAAACNNNNNNGTGC,GCACNNNNNNGTTTAAAC,CCWGGCGCC,GGCGCCWGG,CCWGGNNCC,GGNNCCWGG,GATCGCGATC,AACNAACATGTGCGTGC,GCACGCACATGTTNGTT,GCACNAACATGTTNGTGC,AACGCACATGTGCGTT,TGGCAAACAGCTATTATGGGTATTATGGGT,ACCCATAATACCCATAATAGCTGTTTGCCA,ATCTATGTCGGGTGCGGAGAAAGAGGTAATGAAATGG,CCATTTCATTACCTCTTTCTCCGCACCCGACATAGAT,AACNNGCACGTGCNNGTT,GAACNNNNNCTC,GAGNNNNNGTTC,CCAGGWCCY,RGGWCCTGG,CCWGGGWCCTGG,CCAGGWCCCWGG,CCAGGWCCTGG,TTATAACNNNNNNGTGC,GCACNNNNNNGTTATAA,GCACNNNNNNGTTATAACNNNNNNGTGC,GAACNNNNNNTAC,GTANNNNNNGTTC,GGCCNNNNNGGCC,AACNNACTAGTGC,GCACTAGTNNGTT,AACTAGTNNGTGC,GCACNNACTAGTT,AACNAACTAGTGCGTGC,GCACGCACTAGTTNGTT,GCACNAACTAGTTNGTGC,AACGCACTAGTGCGTT,AACNNNAACGTGCNNGTGC,GCACNNGCACGTTNNNGTT,GCACCCANNNGTT,AACNNNTGGGTGC,TTAACNNNNNNGTGC,GCACNNNNNNGTTAA,CACNNNNNNTCC,GGANNNNNNGTG,CACNNNNGATCC,GGATCNNNNGTG,GATCTAGATC,CCANNNNNNNNNTGG,CCAGGCCT,AGGCCTGG,CCTCGAGG,GATCCGGA,TCCGGATC,GGCGCGCC,GCGATCGC,CCWGGWCC,GGWCCWGG,GATCGATC,GATCATGA,TCATGATC,GCGGCCGC,CCTGGCCR,YGGCCAGG,CCWGGNCC,GGNCCWGG,GGCCGGCC,RTGCGCAY,GATCNNGA,TCNNGATC,CGCGCGCG,CCTGGCCA,TGGCCAGG,CGCCGGCG,GTTTAAAC,GATCGCGA,TCGCGATC,TTAATTAA,VCTCGAGB,CCTGCAGG,CRCCGGYG,CGTCGACG,ATTTAAAT,GCCCGGGC,GATCTAGA,TCTAGATC,CACCTGC,GCAGGTG,CCTNAGG,GATCGAT,ATCGATC,CCTCAGC,GCTGAGG,GCTNAGC,CCTNAGC,GCTNAGG,GCTCTTC,GAAGAGC,GGTNACC,CGGWCCG,ACCWGGT,RGGNCCY,CCTGGAG,CTCCAGG,GGTGATC,GATCACC,GATCNGA,TCNGATC,GGGWCCC,GAAGATC,GATCTTC,CCCWGGG,TCCNGGA,TCCWGGA,RGGWCCY,TTATAA,AGGCCT,GACGTC,GTMKAC,TCCGGA,TGCGCA,ACCTGC,GCAGGT,GGTACC,AGTACT,GGYRCC,CCGCTC,GAGCGG,AACGTT,YGGCCR,RAATTY,CTGAAG,CTTCAG,CACGTG,GRCGYC,AGCGCT,CTTAAG,ACRYGT,ACCGGT,ACTAGT,CACGTC,GACGTG,GWGCWC,GTGCAC,CYCGRG,GGGCCC,ATTAAT,CCTAGG,TTCGAA,GCTAGC,GKGCMC,TGGCCA,GGATCC,GRGCYC,ATCGAT,CACGAG,CTCGTG,GGCGCC,GAAGAC,GTCTTC,GCATGC,GTATCC,GGATAC,TGATCA,ACTGGG,CCCAGT,CTRYAG,RGCGCY,AGATCT,GGNNCC,CTGGAG,CTCCAG,CTTGAG,CTCAAG,CGATCG,GGTCTC,GAGACC,YACGTR,CCNNGG,GAATGC,GCATTC,WCCGGW,GCAATG,CATTGC,RCCGGY,GCGCGC,GAGGAG,CTCCTC,CGGCCG,CCCAGC,GCTGGG,GTGCAG,CTGCAC,CGRYCG,CGTACG,CGTCTC,GAGACG,CCATGG,TCGCGA,GDGCHC,TGTACA,TCATGA,ACATGT,GTATAC,CCWWGG,CTCTTC,GAAGAG,GCNNGC,CCRYGG,GTTAAC,RCATGY,TACGTA,RGATCY,GCGATG,CATCGC,GCAGTG,CACTGC,CCCGGG,CCGCGG,TTTAAA,GGCGGA,TCCGCC,GAGCTC,GATATC,CTGRAG,CTYCAG,CAGCAG,CTGCTG,GAATTC,ATGCAT,CATATG,GTYRAC,AAGCTT,GTNNAC,TCNNGA,CAATTG,ACGCGT,TCCRAC,GTYGGA,GCCGGC,CMGCKG,GCCGAG,CTCGGC,CTCGAG,CTGCAG,CAGCTG,GTCGAC,CTYRAG,AATATT,GATCGA,TCGATC,GACCGA,CACCCA,TCGGTC,TGGGTG,WGTACW,TARCCA,TGGYTA,TCTAGA,GGATC,GATCC,CCWGG,GTCTC,GAGAC,GCWGC,GGNCC,CCSGG,GGTGA,TCACC,GGWCC,GCAGC,GCTGC,CCATC,GATGG,ACGGC,GCCGT,GCNGC,CCNGG,GCATC,GATGC,ACTGG,CCAGT,GGATG,CATCC,CTCAG,CTGAG,GGGAC,GTCCC,ACNGT,CTNAG,CAGTG,CACTG,GACGC,GCGTC,CCCGC,GCGGG,GANTC,CGWCG,TCNGA,CCTTC,GAAGG,GTNAC,GAAGA,TCTTC,GAGTC,GACTC,GTSAC,GAWTC,GCSGC,CASTG,ATGAA,TTCAT,ACGGA,TCCGT,CGCG,CCGC,GCGG,GTAC,AGCT,GCGC,CTAG,GATC,GGCC,CCGG,CATG,RGCY,YATR,ACGT,TGCA,AATT,CCTC,GAGG,TTAA,ASST,TCGA   
                                    6                                                                                                                                                                                                                                                                                                         0                                                         
                                                                                                                                                                                                                                                                                                                                                                    	                                                                                                                                                      
                                                    	                                  	                                                                                   .                             *                                                                                         7                                                                               )   Z         	                     	                                                    "         0   1      
                           J   ;                           	         /      	               ,      -      #      .      	                  
      
      $   5   <   )   K   %      I   1   /   *   Ö   ’       %   2   B   F   ,   Ê   G 
                6                                                                                                                                       0                         
                                                                                                                                                                    	                                                            
                  	            	                             .           *                               7                           ) Z   	       	                  "   0 1  
         J ;         	   /  	     ,  -  #  .  	      
  
  $ 5 < ) K %  I 1 / * Ö ’   % 2 B F , Ê G  µÒ  ¸  ¸h  ¹  Á
  Ên  ÕæQºD¶ýP"ƒ"Á")*mò-ò9Ò¢Ž��­íò á
m‚¤?ð.˜-ùòÐ’Ûj—¬Àî“>—Þ ["£"·"å"$$¬%«&ˆ'Â'É'o(t)Ó)å)‹*¢+-,-P.x.%ÔdÊ!õ-ñ_è'e/`¶Ÿ$C#ó¤^+òð»ÔS"™%œ€Á!¤$*"pMW´¸]'}®å)Þqñ8 *åç!Š'"ŽÕ žA¤O‰)‰)P‹ðÅ†Ñ¢¹%‚?.Ð“x.åéÏ	6
Ã
—åN:Ö¤8´Äµè*Í¢ö½hxâD—_¦ ç!:"�"­"##Z#À#¹%Š'(ò).,L."/B/50�©K¥×!©ýlYøfB$A 0 OÙ’Ž%ÔÜéÔ -!J!k'<-Z/0ñ	Ù’%‡Ô£é-!J!k'Z/0Ù’%Ôé-!J!k'Z/A Ù’’’Ù’’ž©È©	Â	/Êññ÷#e0Þ)|¡"©ýHº…\'=%Ñµ
õ|§#.ªï©þ´Æ
J¥‰ªï©þÀ'R#
lö§îE0ßB&	>"€˜$ö+ó# º|ê#:4®ßB&	#ñ9ª´•	ÞöNN  4<M.öNšë�H±aE	S{ú©�ê5�K>aýƒ© "z,“#ƒF*	&z‹(> ó�©iIM,^0`. )”%` )©ê5�K>aýƒ© þ	
­'ïU'Á5Ã¤	¶¯ë]¿ ¼!Ê"©0S#9%#qÃ#‰RRgVÍŽ$u¦>•ÚŸºqR™ Ã#¸£&¼Ê
ùÎ&t)Ö›¢)Ã&µÁ
Ç
¥ÝšLSÖ!Ã"ƒ#¿'Ã'EÜPA€
r$©'ì.¤/* 2G¹F2#Ò+{–·#V ¤(½(ÿ(D)¬ÚTÃŸºÐ!œ%ž&U'úüf"a1<&_Ç¨	Ô�Ã)à$Ï!Þ #ô6Ÿéw°÷ý*ôý*»™©
ßM%}:	èDˆ¦·!K#ë#['|'H0û "{,nR	 ¦$[-‘;÷ùûô– "ý*{,š¯
ƒyû*æ£éwÅ! "ô"{,~/Ê«´•	Þ˜È¸«ò [#mƒïydp*ÚŸº»3àÁ' !Ò!'V#w#”*‚	·õD6&u3ñ"'Ÿâ…å£
;]ë·‘#$Ì*‹+<0ØÚ7ôú´Ÿ¯üºf"`#Ù'·*Ž]|u‘¦û¯
>•5Úõ�ƒ5�ŽŸyºƒê¢©ªÄqR” ™ Û ç =" "¡"õ"Ã#$(á)*z,{,O0t¹gR”#Õ î	3+I Xáæ™ÔÜ©-*H,X¹à$.V ¤(½(Ó(é(ÿ(D)"€ò‹©
ª
Ä
8­&gÖ01¨:dé¶‡ól¦=l\ ë!n"{"¤"#r#ú'"(d)c*-¢.I0¬H.•.¿ìÊ©DÏ#‘*$+š-Ë$%0df « å�ø Dø!�"…#À#d%Á'(O.Üôw‰”›Î<Çâk°ëîx€ ®õ ÷úýZ µÇ
Ö!Ã"ƒ#¿'Ã'ï$k y}ü‰èó*çL|.µ"µô;	Ç
X¹	ñàÖ!Ã"Ì"ƒ#b%¿'Ã'+$.�Ö"ðÊ½É,.òåVÂîz/ùûô–*6Ÿæ£éw°÷Å! "ô"ý*{,~/²Ûåý/Ç¨	�Ã)Ã¤	òg"(ŽË^¥�&HnP&â.—#åî>;A0÷�ÍÑÕ¢äûh~ˆŒ¢�UmÜô ø!�"ž"­"P#V#w#~#…#¼#Q%›&¦&Á'î'�()r)~)Ò)÷)',Î-`.|/òÄ
8Ör#ú'é$üÇ¨	s�ô!V#w#&Ã)^0Ž0w¯
K%]ƒ”¦y›$_'Ž)D,O,(-_MMèd”"ä«.0\.©
:¦Ä
r#$ h‹0Òï!Ö&ÿ'�ß!*�*éw¤ÖwŽ2!* t2¹G¹F2gR”##Ò+Õ{– ·#V=
D7[+,,FÔæÁ
#Ï+ÜPÞ¿	ˆ±-».Ð	á	7
Á5\¶d¯ë"&"Ê"é$Z0d Ð  Á5EôÃ¤	\¶òd¯áë]´ôýí*¸ì@¿ ¼!"&"I"€"Ê"Ñ"é$5%ð&ø'(ý*Z0Ø AŽ˜šÅß²B&	!
Î
Ç>Îà"0—¸åð8n€
ÁñEÛç!DVr’ÂÝÖ0¨9˜´ø
ˆ©»î÷*ÕðYå.{
~Q Å ¶!"&#˜$q&æ&t'¬*2+”+ö+I,Ô,¼-.~.Ã.z/ý/G0ËÔJ‘É!'�*9+?-H-­¿XG…)Þ. /å�ø!�"…#Á'¹Ä
Céñûj´¿†ýWvæ"r#¯#¡%+,z"Å"×·ml%»™ß}	·!ë#Ÿâ£
;]ë·‘<0Cñj´ýv¯#Á5¶¯ëÊ"I a»™î	ßXá}æ™	ÔÜ©1·!ë#<&-*3+H,n.ªBl¬tµ–	WFfß}§î #§3-‰:nRŽTRÍgVÍŽ$¹$%™,¶.õ•ßB&	Î
{©w¯
K%ƒsyíŽ)D,¦.A  1°
„9•f§zGœ$`'ú+P,)-E0#€‹bF	­&}‰1a¨òT¬ÆJô*“>lo"¥"#�&5'Þ)W*d*,-‘.ÕŽ=Ú! Ÿ!×"ðÊ½É,ò9 ".,0éXˆ8Õ	<
?
¥
Eó\_±CFÓú-Ýâi´³¶¾å�ãüÃY�?#{#®#h%ˆ%é%.&+Z+]++,;0|šÃe‘ïûüÞ
ó
|ª!6Œ¤�ë”¶6 8SŽïL(©?bþ„ª” Û ç  "¡"Ò#´&'){,|,30òþ©
ª
T÷£/:;¤d�¦§Ô!•%í%²&Ó&É'd)>+c,¢.àÙqŸo6÷�-°.‹
…Qz©³á™!Ý#x%ò&-…-u.‘ïÞ
ó
ª¤ë¶6 ŽïL(©?bþ„ª” Û ç Ò#éXÕ	<
?
¥
_CFúÝâi³¾ãüY�®#h%ˆ%Z+]++,ˆ8Eó\±Ó-´¶å�Ã?#{#é%.&+;0©ÄßÇ¯Ç`§ "�%j&/�§«ˆ	Œ	Ë	2
Ò
RÁO5Ðœ�ä u&‰)!-Ú.uzë
óuŠÆÄ‡n„"Â"š%Þ%{)©+2Bšñ~Õ«â!«%¶&ó,´·éXˆØò»8Õ	<
?
¥
Ã
Æ
É
Eë�ó\_±CFÓú-Ýâi¤´³¶ß¾å�ãüÃRYíY�7"?#t#{#‚#®#h%ˆ%¶%é%.&‡'¾'Å'ï)Š*+Z+]++,®/;0#€òþ‹bF	©
ª
­T÷&}‰1a£/¨:;¤òTd¬ÆJ�ô*“¦§>lÔ!o"¥"#•%í%�&²&Ó&5'É'd)Þ)W*d*>+c,,-‘.¢.6}ÂØ	40 3³ú “"*·,î-f.½.D/˜/LÎÝë¾	†
{N‚É Î%‰&1'°œ/u3½"ñ"˜#V+c+u¥œ!Œ$'Ø+ø.K�ª‹	.
¶j7Dz„F!ü%t&ˆ) -->Ã5¡rÈ_Ý!k&™/!Ûþ–þ›?5ìÜ# å&Ö*o, ÷Oò:"Ûí”'.i5#­Üî"—%X. âŒ�Üi«Ö°•Ü #X'¹ Þ 6Å´çª8	^	w
ZÕñ(ó›×@� ‡ Ö #"Î"á'�)ä)º+ù-ß/ð/O œ í  ÷!OÛþ–ò:þ=m›"Ûí&M<N”÷?Ø5°ìÜ# J$'%å%�&å&'J'Ö*o,.¯0å™v�× q,¬. ¯š0:!U+b+\.²TÃÓQ.ÔJ!Ð!)*k,[`¦­+%�%Ÿ& ?ª¼i²Þ"q#§&s)0 Ñ�äû3Šh®a"ž"~#£%›&)2)~)…{¥á;‡Î+bzõ¹µuo¯çA;6=AV:®a º!È"é#q'%)ª)6+<-B-—-C.{.Ã47\a¢ä
‰¸®±t�P],Ï!v"ß'y)(*µ/> ˆw[eH,	ÀÒ(xÄDYn}ì‘óH|3Ý$ ^ e#Ö%'�(Ú(3*�*â+h,ƒ,¡,?-ß./3/!0ƒ >�+6Ú\
z\!g!z&©*ß+, ”,X·ò42ªÎ–áöP4rœûp¸Áß'<–d Ä™½L“ ©"-Y î<Õ—{	œ
{Ò²ø0D/v Ü#Ý$È%&A&d(À((+g+Û+�,Ž-µ./0k�¡ #&Ë(èÿp¾ir§õI»3HYnŽ”89asvy—»´àÁ' !Ù%P&µ+M,â.˜ ¨ « ® î YsÙs	i¨�`cÌm…_¦Ó!'‡.{;zA®º!È"6+áõ¯;=é#B-Y î<Õ{Ò²ø0/v Ü#Ý$À(Ž-…¥‡Î+b¹µuoçA6V:a q'%)ª)<-—-C.{.´·Øò»Ã
Æ
É
ë�¤ßRYí7"t#‚#¶%‡'¾'Å'ï)Š*®/ ¯å™vš0�× :!U+b+q,\.¬.i°Ýl’F~o'¾,ÿ,´ [+±‘	u	ß	^
pª d 4{ {!€!?(Î, .ü/\ s BIËBM"ú%Ë.t0_"3-"Z"m&ð.“0_Å
 !´¡ædWÃcájÕáïBSk{0ÇÝóõ÷�"s#&(ñ)6,".{/­/ ‡ ¸£¹&@­¼ Ä
Ê
Åùc«½"]àiaj†jzäî�³à!8"A"ß"r#Ç#É$%¨&Î&ˆ'Æ'ì't)ð)*‹*ž*+,0 ´ÓØò:Ñ	Æ
ë�å¢�ý¤Áäûâ3RŠxRYh�®Áºøˆð!ü!a"ž"è"t#~#‚#£%¶%&›&×&¾'ò' ()2)=)~)•)…+,®/Š;o·EVó	u
S�Ð„žU‚ŠMSôÎQØÿh…WnÎìr0"Ó"Ä#�$º$%Ö(ì(É.G M R e Ÿ Í ã þ1@ÑA
DíkwŒò[aHÒÞ,gßäkØˆµÄ÷¥´ðb‰ð`ÒäMe�¡ÚþB&wêxŸ'n °#[%j%è%L(„(j*Ä*ò*ó+:0|Ù
"Û8õûµ 1°ýA»1ÜÞôög"T#a#Ú'((u*¸*+Ê+7,.S.d.B/B[à<—Cº'	›	Ï
Èžøå
|˜á$h'’)²+A �ã 1ªFx·*	˜	
°
YƒºÙBLêH’™
&^hl„ÏAL¬9t•¸!fºö>’§ÔzîE#Gá<œ$ &7&`'¶'‹(�)ú+E,P,X,)-%.§.E0|šÃ¶fôüÂ
È
]}!7	Œ‘”­¦8TÞ› ÉM#Tð×!¡"Ä"„#h&x&µ&'À'Ä')Ñ)Ü)î) +|,Í-°/40óæíÿª
U÷�Ë£ù/;¥dª!�E‚§EÕ!ù!�"†#Á#Ð#e%•%í%²&Ô&Â'É'(o()d)’*%+?+ý+c,›-P.¢.½ýó³È©	È	'†ÜfÊÐæt‚‹©ðÂ!õ!W#x#�#2$Å%&d'n'Ä)‰-º.-/�/þ/_0G M R e Ÿ Í ã |šÃþ1@Y¶Ñ†&fäôü“™A
U
§
Â
È
D]x}õûrí!7kwŒºËò	$+[aŒõHw‘±ÒÞ,”gŽ’­ßäûRk|™¦ÐØ8TˆµÄÞ÷¥´Ùçðþb‰ð\›`• Òä+Me��¡¥ÉÚåþM‚’#BT§Ëì&pw€¤Äêðx–Ÿë'u2 n ¼ Æ!×!6"r"¡"Ä"õ""#>#„#ˆ#°#»#P%T%[%j%Š%ª%è%h&x&µ&' 'z'’'À'Ä'( (L(„(•()),)_)q)�)Ñ)Ü)î)*j*Ä*ò*÷*+_+ +«+Ö+ó+|,ò,Í-Ñ-ö.J//°/É/40:0 ¶ h¢¤½¿	!0^bd†©«½ý!#]Àó³Éìî~‰�“ÄÈáãb	m	w	¥	©	Â	Ä	È	Ð	Ò	á	ã	ÿ	

'
7
9
D
F
`
¿
'px†Üf¾æêÊÐ}÷µÎæöXZt‚‹—¦ºØ©ðo!q!Â!õ!W#j#x#�#÷#$$2$=$?$O$B%Å%&—&d'n'®'7(9(;(A(W(Ä)*M*Á*~+Ð,ä,-‰-°-º.é.-/Q/‡/�/�/�/Æ/Í/å/þ/0_0e0W ßXa‚�,ûJl�+ÅÐ!!?!Õ"¡#Å$%Ä&V'¥(¾(Ô(ê( )E)·/ ãèMûÇõßÀ	Ô	;
¤
<}^/h¶ì¸’‰X"Y#€(þ*&,Å,²-K.¼.0=0a0` F›Ý(ÌeŽ¸ÞõQq�U	
BaÁ�F]h|·í€$s$z$¥$©$´$ñ$ü$0%ª'1(D(P(–,ž,È,^-7.í.¥/þˆŒ–öùüÿ:V_lªÄÒ_š‚	Þ†­Ë.“îW¹-|<~É˜ÔOÐ¶ÀËe¶%‡ßclãò†Y \ Í k!U"¯&S)o*e-²/¾)ùw‰Œ¼F”Q›Îéô<?FÇâå�‰çkt€ž°ëîñ‹hqx{€ƒß	m5&"4ëéü …®õ Š!í!}"‰"#^#	&�'v(6*z+-å.K0% b ö bÊPiR�³àï÷,oS	„	,¡ÙQ‚ ŠJ2o~ÁN§$²$¿$Ö$ê$ú$%%=&˜,\--.¨/Œ0G M R W e Ÿ Í ã =þ1@¿Ñßk©µÙRXaaÁE	¢	ì	õ	A
.D”©9Z½íkw‚Œæò[a|…¦HÒÞí,�æ%4gp¸Ðß8ØäòkžÈØøˆµÄÊÓ÷KV„¥´Ïð,bnt‰°Úð(ý'`ºÒä5AMe�¡ÅÚþaµêý9B¢Æû&Jbw¿êl�+xŸ'NUÅÐX n • œ !!?!f!T"~"Š"Õ"#¡#°#Å$ç$%[%j%è%Ä&V'‚'L(„(¥(¾(Ã(Ô(ê( )E)7*j*˜*Ä*Ð*ã*ò*{+Þ+ó+W-s-w.�.%/g/·/:0|0²0{ 9’¼ÂËÚ6š¬µ–	„
Wå·D’°Ðà?Ffnnàì
~œ®Ï>vÉ;
»�bÓß6Îƒ¸!"Ë"ì#%Þ'x)'*³,F.´/  Ló     O  0´        0´*=fo‹Wxd©^0Ç[†õ;S”íÈpZS¬¡uÁ^Ç£ëÍÖvÚºé:ªºë¬­�*ª¢¦Ó§jºÉ:²«®ª^¯kª‰º*Ù*/ÐiCl_­E¨hYWn¶ºQ˜Q–ëUø¸TQÐý©˜EÖI«¦d?jR…]nµRýÛ:FQWá*ftäK’-VùùÑ
¤NEdÔ¥YC’ò›^…Tƒ|Kêª/ëk�½·x0ó±&ÆS¡›¾4�2ÂÈÿ»‘a6�‹”¦UZ}Ùªª-ÞŠ…#J››©�™©^§¹Å–e¹’yÖY´Š¤E¶eat¤v•Zj‡]¹Ò©º©"6"»êª£VN·æež¶ö©¤�½©¤
X*¦G–ª¤�¹ªkš¤û•¥yW¹ªJªš–Z‘™VE•eHyU¥ugú”V•Uåvªè«FXôø¥sËK—}}1}4Ë2Àõ1M7»‹8û�ÿ»+Î÷Ê£¼âÃoEc Á0ÑÈOÃC¾ûîÜ79À¾¯ß;ë:¿¯³óÉedwÿ½ßî¯õû"ŠÁ3wwuônÿÕ½ü°ß¼ëPœó²ûÿÿÿ»Ÿ®äl2¼/`¤ÂJç®+b¢)È¨ŠFò8äÊÉÜÇârÑÜ®9z="®ê [à;“ÊóG±«aªª*Ê6@¨*?ªúšµ™�#z*,n«cªª.‚ˆaˆ.
+‘°I¸«WŸ‚¦–¨‰ˆˆövkd§…``VlnA�™Ø¡Œ
§†6gDcªŠÎ‚ˆaˆ"
+k+‘°Ix«WŸ‚&¦–¨‰ˆˆ¶vëd§¥›�d&v(b©á�™Ø`Ù�6æ¶c¹~„Ÿ›še•Ô˜ªe¦¨n†g aƒf4Ó™ˆª“øúÙÎjj:	â®¨±ŽßâŠ‚)ë�? ýg¢`ó;‘�§P}Ç iÔqÚuaÔ`ïQD(6÷ �N8užÆÃìö€y{ŠÈmñÄ�B?µE+P¾]ñ°ÚöÔQnÚîø¬tÃÃ„9Ì;S7ÏÍ's4[6ãŸ�j»×ƒ(q®®½ÐàA-¯²eÜL6õºÃ]¢Ç£çÜE'ùÆçÛŒS²½Ñ”0~óá¹û;ƒ÷a¥+@=«á± µüdÆ(u8­½;#G'_NëEÿic-±ÌPæø¼ä;±K°Ï±á³ôãÀÄQEÃâ°í£;O€;sõëRÅ«³„õ8Ó»ÔÙÇ~_¾Ñ°ÆÒsâ¾Î=E¸°sÛï‹†k´]ñqC¼îÓïaµ3œq7ÛA¸¾3‚ÐÓNÿIÔºëK\9Îv‡îÐA+�JÛSÆ¸FÁã‚ílÄ¾SL¬eÃM¿wÑ­» N79¾CA®«íA—ÌEF¸z´òyËÞÎ@5ïÎ³ aüÔ´AmÏ ^± ±ÔäÎÒÊÛZ±Ô_�VB;ùMìï‰Äž·K�q8yB˜‡Ä„ðêø¸4QCÛ ~ø­G×ÁBÜ)M;PAç­E:Æ°±¸2„:×>þ ~}Æï…iA”¾\AfûvˆáÞÞâ±ÀFLøQéÏÛºÆBØSNÔA'|8 C„ÐS¶×¬SKÀQÆû¾L`ë1|Ö­�8kq‡O·kPA›ÑC´!0ô {8ÜM›1~ÎÏNmE k�!BˆNP¶Cu>vËhFÀE´}ÍE·1aD@ÚPN ¿FûPMü EÜÓ�NçâyûÑ`ó‰ˆA8¥Ðí1§±�l¯t¶¾{Úuíô,EðK†X¯­BÊQF^x3Ó¾=NsL¬eûuC„@0;¸NPÀëmD4à±ÃFÞSrŒÑ®Ç·yIÆaÔá¼Ä!BÛ…-S²ï´½+�B°µÖŸ}�Øs'ás,7NáµŸÕ;1+"p�B§„a³Ô°Mh5|õ'®¹î]¦®µ·¸=`Äo3ÿ¶ÄqpÄp"Ô«1òÐP®ïcÝHY²ÔQÑÑàÀ®åµ®>SÓNÛ?5¼QIÃ±ÓýâžÂø(ƒ(ERõíDÈPN8·`LïN±_ÆÆ¯�P9Ô…†ÚS¿ÔžÞë�0cƒ¯818Ñ@ƒ¸òõ&!zûŸƒïÞqí@ÓüA×E4â²ÄÓu6Ÿ±Äm¡4jñ+½LÈoƒÇ1nP¾ï2uÔß1Ôõ´Ðám­»­þ_°Ïøã«RzÇuæÆÍD'u7”¾1þÛßK|>çÌÛ‹´ì ÇSL1Å0QE¼ìÏTQL,;SßTQL,;å/íó O7ø!ÊÔŠË·PHï�Þ;M*|!Ž^uì‹û}8qO)®óàEOÀ¿åSùýœbþsí„í½�I ñjÿ+WjeJºQ¡oŠ<.Œa¦Ù–®(Zr”Ø–Z]‰caÊja
©†‘/Íi�©g1‘WU™35yV›30‹nbžFÀZÞ,ªuË!àƒ)ýz[>�7oþ¬ô|NäZÄ0¨É äM:=vqÞì¹ïQfÕÒí}P9¡«]P%›_¾Á¯hý9¸·­µPt‘T ß�XöÚ1•C›+Q�¸ñÒõFÿqÛ UE¯_rëTÔ�¡ˆeØ MÇ{²ç½E›TgK´Qõ@æ„z­u@–l~û½£ôæâÞ¶ÕAÒEPPƒ~ucÛhÆTl­F>ãÇH/ÕýýÄl�Ur½}Ë­SR†!›½áÉ@aÍÖýæúÍGëîfPR¶­¨s…mô»»�[›»±.}„ýü<vóÈ÷Ä0v<0¸ßlµ÷�±MÂ×¯'ÄóA|ÐH~ËËŒÎoàì³Ä pÄ,ðÛ>sþÍsçÇÈœ»ÿÏ}0p½Îç~8Rþ7@ëQ28¶ÀãõÇñ23cqì�ÿ0Øãµ7x6€«ƒN­><'Ïòð¾?-ñ‡±*ïe–"Jý@Z@¯™¬íˆ¡6eþ’bj&¢Už¹µ•jå¯•}VôžU½ÿ–°ÊZÒv•\¼Ö"šR‹y-
^Ö°ÊZÒv•\¼Ö"šR‹”ËZŠ�÷Y›ãßOO];ü|4ì7U·ÞÆt4ý´¼´ÀDò‰C£¶)ñŽkyN<
…w³	6(h—tL£�ˆméIyytJ‰ÍUo-®:J†>*`ÀËãóßïÊ:Ýrµo;ðÁ¨¾{A+|uuÑ•qPý.¼xO«*š†>+ùîÎ’JG/ñØä}…½üD(óêÀê®ªÕUU©•q¸£<
 5C; 5ó£
/p0OÌ“6‹ÝOP1õ–†ff¶ZNZgžŽ%ç£Á1 Š�N(nšL®Ü�ª†“·!úi1«r{Æ“·'øi1«rJ¨ÁSü…µ£ ÚL*Ü�—Ÿîot:ðUSó±ÃŠ nL%œ)½Ñm eÍEØ„ÕCÓUA|•Pó(àÊ«ÙóÿáÄÛuVÇ;RÑ1_ÇAæTgÐÊ¿øïìŒîø¯ãÎŸ~/>®þ°È3«¶NÜâBnÒ°‰+;Ôà8ˆÜ_ÿ+OÇÎ3é¼%æË¡/_ÂQÜzl÷ƒM=à—A¤Ñ1	‰#�º‚—œ9ÞEI¨&ã;Žô§ëTJ	;¡¼5u}ó‚L ª¨¨ÔÓFœÍUíEêªçÀ¸s´�pÖáeŠuõ¥õ®EW¶ÄÛVãZšÙ´mgÙª…Tò®%…Uíñ+ÙFø&Âãñì½vÖuù¥«þËUe
mHEmöx[Â`ÕJ˜Úº½Š×CÓÚs²ÛU·³m}_)­¬†ŒøLGœÆÎ)TiÕÐ[5ðÍÞ=3muš­ø[Ašë–~Ž*¯ lÒI}�¶ÐIÁ•c¡‚ÁD6V¼´ô©.nÛ‰vÚsŸ¨ö*Ñ]{ƒ6Àëöu1‘¢Íøhüv›1?jgöem6ö(¥³±Ê¿(Yƒ¶]ÿ¢iâ¦%4tªh­†š©º#X—mªÜDãJ†ü@ø‚‡cvu`qpe~«sú¥fòšå•Îê»¤       i  Ð  0³  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  ;f<?xml version="1.0"?><Features nextValidID="27"><Feature recentID="26" name="sgRNA1" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="550-569" color="#a6acb3" type="standard"/></Feature><Feature recentID="23" name="U6 terminator" type="misc_feature" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="646-652" color="#a6acb3" type="standard"/></Feature><Feature recentID="21" name="AtU6-26 promoter" directionality="1" type="misc_feature" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1"><Segment range="107-549" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;&lt;div&gt;Synthetic construct guide RNA, complete sequence&lt;/div&gt;&lt;div&gt;GenBank: KT827739.1&lt;/div&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="gRNA scaffold" directionality="1" type="misc_RNA" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="570-645" color="#00ccff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;guide RNA scaffold for the &lt;i&gt;Streptococcus pyogenes&lt;/i&gt; CRISPR/Cas9 system&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="25" name="KanR" directionality="2" translationMW="30729.62" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="11431-12240" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to kanamycin in bacteria or G418 (GeneticinÂ®) in eukaryotes&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;aminoglycoside phosphotransferase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;aph(3')-Ia&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q></Feature><Feature recentID="24" name="BlpR" directionality="1" translationMW="20638.01" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="8644-9195" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to bialophos or phosphinothricin&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;phosphinothricin acetyltransferase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="function"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;Streptomyces hygroscopicus bar&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="protein_id"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="22" name="dCas9" directionality="1" translationMW="158203.57" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" consecutiveNumberingStartsFrom="2" maxRunOn="7403" maxFusedRunOn="7403" detectionMode="exactProteinMatch"><Segment range="2892-2915" color="#993366" type="standard" translated="1"/><Segment range="2916-2918" color="#cc99b2" type="standard" translated="1"/><Segment range="2919-5405" color="#993366" type="standard" translated="1"/><Segment range="5406-5408" color="#cc99b2" type="standard" translated="1"/><Segment range="5409-6992" color="#993366" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;RNA-guided DNA-binding protein that lacks endonuclease activity due to the D10A mutation in the RuvC catalytic domain and the H840A mutation in the HNH catalytic domain&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;catalytically dead mutant of the Cas9 endonuclease from the&amp;nbsp;&lt;i&gt;Streptococcus pyogenes&lt;/i&gt;&amp;nbsp;Type II CRISPR/Cas system&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="locus_tag"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="protein_id"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="20" name="KRAB" directionality="1" translationMW="7404.74" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" consecutiveNumberingStartsFrom="11" maxRunOn="7403" maxFusedRunOn="7403" detectionMode="exactProteinMatch"><Segment range="7152-7337" color="#993366" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;KrÃ¼ppel-associated box (KRAB) transcriptional repression domain from the human zinc finger protein ZNF10 (&lt;a href=&quot;http://www.ncbi.nlm.nih.gov/pubmed/8183939&quot; title=&quot;http://www.ncbi.nlm.nih.gov/pubmed/8183939&quot;&gt;Margolin et al., 1994&lt;/a&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="gene_synonym"><V text="KOX1"/></Q><Q name="gene"><V text="ZNF10"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="protein_id"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="19" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="10753-11341" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="direction"><V text="LEFT"/></Q></Feature><Feature recentID="18" name="pSa ori" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="10203-10638" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;origin of replication from bacterial plasmid pSa&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="citation"><V bool="1"/></Q></Feature><Feature recentID="17" name="Shine-Dalgarno sequence" type="RBS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6905-6913" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;full consensus sequence for ribosome-binding sites upstream of start codons in &lt;i&gt;E. coli&lt;/i&gt;; complementary to a region in the 3' end of the 16S rRNA (&lt;a href=&quot;https://www.ncbi.nlm.nih.gov/pubmed/7528374&quot; title=&quot;https://www.ncbi.nlm.nih.gov/pubmed/7528374&quot;&gt;Chen et al., 1994&lt;/a&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="16" name="rrnB T1 terminator" type="terminator" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="9948-10034" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;transcription terminator T1 from the &lt;i&gt;E. coli rrnB&lt;/i&gt; gene&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;Escherichia coli rrnB&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="15" name="rrnB T2 terminator" type="terminator" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1"><Segment range="9829-9856" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;transcription terminator T2 from the &lt;i&gt;E. coli rrnB&lt;/i&gt; gene&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="14" name="nucleoplasmin NLS" directionality="1" translationMW="1739.18" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="7403" maxFusedRunOn="7403" detectionMode="exactProteinMatch"><Segment range="6993-7040" color="#993366" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;bipartite nuclear localization signal from nucleoplasmin&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q></Feature><Feature recentID="13" name="SV40 NLS" directionality="1" translationMW="883.15" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" consecutiveNumberingStartsFrom="126" maxRunOn="7403" maxFusedRunOn="7403" detectionMode="exactProteinMatch"><Segment range="2847-2867" color="#993366" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;nuclear localization signal of SV40 (simian virus 40) large T antigen&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="locus_tag"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="protein_id"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="12" name="SV40 NLS" directionality="1" translationMW="883.15" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" consecutiveNumberingStartsFrom="126" maxRunOn="7403" maxFusedRunOn="7403" detectionMode="exactProteinMatch"><Segment range="7059-7079" color="#993366" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;nuclear localization signal of SV40 (simian virus 40) large T antigen&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="locus_tag"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="protein_id"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="11" name="SV40 NLS" directionality="1" translationMW="883.15" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" consecutiveNumberingStartsFrom="126" maxRunOn="7403" maxFusedRunOn="7403" detectionMode="exactProteinMatch"><Segment range="7095-7115" color="#993366" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;nuclear localization signal of SV40 (simian virus 40) large T antigen&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="locus_tag"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="protein_id"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="SV40 NLS" directionality="1" translationMW="883.15" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" consecutiveNumberingStartsFrom="126" maxRunOn="7403" maxFusedRunOn="7403" detectionMode="exactProteinMatch"><Segment range="7344-7364" color="#993366" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;nuclear localization signal of SV40 (simian virus 40) large T antigen&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="locus_tag"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="protein_id"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="8" name="CaMV 35S promoter (enhanced)" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="7922-8599" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;cauliflower mosaic virus 35S promoter with a duplicated enhancer region&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="CaMV poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1"><Segment range="9202-9376" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;cauliflower mosaic virus polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="NOS terminator" type="terminator" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="7445-7697" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;nopaline synthase terminator and poly(A) signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="Ubi promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="739-2729" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;maize polyubiquitin gene promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="4" name="LB T-DNA repeat" type="misc_feature" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="9526-9550" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;left border repeat from nopaline C58 T-DNA&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="3" name="RB T-DNA repeat" type="misc_feature" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1-25" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;right border repeat from nopaline C58 T-DNA&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="2" name="HA" directionality="1" translationMW="1102.21" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="7403" maxFusedRunOn="7403" detectionMode="exactProteinMatch"><Segment range="7371-7397" color="#cc99b2" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;HA (human influenza hemagglutinin) epitope tag&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q></Feature><Feature recentID="1" name="3xFLAG" directionality="1" translationMW="2730.72" type="CDS" allowSegmentOverlaps="0" cleavageArrows="2840" consecutiveTranslationNumbering="1" maxRunOn="7403" maxFusedRunOn="7403" detectionMode="exactProteinMatch"><Segment range="2775-2840" color="#cc99b2" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;three tandem FLAGÂ® epitope tags, followed by an enterokinase cleavage site&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q></Feature><Feature recentID="0" name="M13 fwd" directionality="2" type="primer_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="7706-7722" color="#a020f0" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;common sequencing primer, one of multiple similar variants&lt;/body&gt;&lt;/html&gt;"/></Q></Feature></Features>
   ±<?xml version="1.0"?><Primers recycledIDs="1,2,4,3,0,5" nextValidID="6"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  O<Notes>
<UUID>040a026d-3f29-49f9-97a4-3e4648a4b873</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<CustomMapLabel>pBUN6I11</CustomMapLabel>
<UseCustomMapLabel>1</UseCustomMapLabel>
<Description>CRISPR/Cas based plant genome editing and gene regulation; expresses dCas9-KRAB, gRNA scaffold for insertion of target sequence (OsU3 promoter), Bar resistance.</Description>
<Created UTC="21:24:26">2018.8.6</Created>
<LastModified UTC="6:37:8">2021.9.3</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
<References>
<Reference journal="BMC Plant Biol. 2014 Nov 29;14(1):327." pubMedID="25432517" title="A CRISPR/Cas9 toolkit for multiplex genome editing in plants." authors="Xing HL, Dong L, Wang ZP, Zhang HY, Han CY, Liu B, Wang XC, Chen QJ"/>
</References>
</Notes>
  Lö     Q  0º        0º*=fo‹Wxd©^0Ç[†õ;S”íÈpZS¥:Ê\ìz>¼Ýgm«®“ª«®ºÊÙÒªª*m:v«¡|“«*ºê¥êö°J¨›¢­’¢ý‘a¤6ÅúÔZ†…•vëk¥…nµPÿ€[…EMÚ™€T]dšºfCö¥(UÖëU/Ý³¤eqN¦gND±I!¢ÕoŸ�ªDäVMJU”9/)µèUH7Ä°Žª¢þ±@Ö¸Ñ›Ûwƒ;±Âle:±kãHÓ!ü,�û¹–hØ¹JeU§Ýšª¢Ýè¨R4©¹º™Ùš•ê{œYf[™'�e›HªD[fVJG`¹Pu¡&¨uÐ{�*›ª’#b+¾ªª5dë~fYëojšIÛÚ�*@¥‚ªdyjªIÛš¦¹ªO¹ZQW•{š¤ª©©e©•dYVT‡•ZWV©EiU^PWj®Š±$e�OŠW<±Ä¹pw×ÓÓL³,SÑÃpÛ¸³�¸û±¼ï| z;Î,6ôV2„ðÜ40ûï¾íÃpÓœ kêýó¾³«úû?<–VGûÝþêÿ_²(¬7ww_Fïý[ßËûÎµ	Ï;/¿ÿÿû¹úîFÃ+Âö
@ü$®zâ¶*"‘¼Šˆ¤o#ŽL¬�ÁŒ~'-Êá£—£Ò*î ¾ƒ¹<¯4p¶ª¢¬£d
‚£ú¯©«Y˜ò7¢¢À¶ê¶:ª¢è(†‚à 0²¹‘kŠµyø jij�¸˜ˆ�gf¶JqhQ†fÆä	�ŠÀªxcftF:¨¬è(†‚  0²¶²¹‘gŠµyø"jij�x˜ˆ‹gn¶Jq*Q��Y±¹Bgb† *žÙ�†˜Ónkf;—èIù¹¦Y]IŠ¦Zj†èfz6cM9˜�ª©?�­œæ¦£ ž*ê‹íþ(¨"ž¸Óð¿Öz&0ó¹uÜp�A÷¡§Pa†FñEABƒopôã‡QIìl>Ïh—¸ à<†ßIÔ#ûTRµà5ß¯mEí ÎïŠÇL18CœÃµ3|üÐÂw3AE³n9øÐF«½q1B‡êëÝÚû AQMÄÃo[¬5Ú,q
>}ÄRœn}¸ÁE; {ÝCï>Ÿ³¸?vR´Ú¾»_ÁÖLb‡SŠÛÓ²4ruôî±_ö–2ÐËÅo‹ÎC»»û~?N<E\>+nÚ3´ø·?^µ,Z±»8AÏS�;½AÝœq‡àeûàým'0~+ìãÔ[‹=¾ø¸f»@…ß§;Îí>öS9Ç}´‡ûáC8-4ïñ�A®±´±EÃœà'hpÀ>í¹Ô­µ<k�`pÜN8!NÖÌAûá4ÁÚÆ\4Û÷}Û°ãs›á4zçú¾Ô|ÄQ±k‡«A¿'œ°ýìä^üë:ÍKDÆÜòëB@ÎLí,­±aÅ«Eøõa#¿”ÞÎøœIët¹×‡”!Iˆ|@ØAO¯‹€E=²ïŠÔ}|-Â”ÓµzÔQ¡#¬k»ƒ(Aó­sïàçÜnøQ¶”AëàuÄao±hŽíî+|a±Ï…œý»¬aÔ-…4íDBwÃ€8M;mpÚÀu4¼o±ëáDÆ³ÍjØÓ†·tûvµ½;B@³�ÄÙ³ìàìôæÔP¸Ñò(�Äà…`47Sál¶„`ü[GÜÑ@ôQ{sA±¥àôoµßÂ]Í8Ñaî~'Ÿ½1˜˜�ô�š]ÓqËöÊ÷KkáA‡½¡×P¾ßBÁÔ_ Ô¸eŠúÑ,¥aEçƒ=;ácÔá·4ÁJÆ_·T8D»„àu¶ÔCNÜ4må7(Íì{paw”œaNÌB-·øRÕ;.ñëAA«Ò¹Ô+]i÷Øý‡2~0‚ÃtîQIýS±²' yÔ*qˆAF=KÐFƒPçÏRzëžåÚajëQÑ{ƒÖFðS?ûlGG ² @Ð³-
îö=Ô…›-E½
îPKZãå0]1Ôí³óQAàÅœ0+?Þ ùì/‚ˆ1B„P5/QNÔL…ã€q¦ÎôëEüljøÅ�AQAøm¥;ýIíî±8pÐS8:óƒ�q8;�/Rb¯¹ø>ýçNÔ?Äq4SN+,M7SiûFÚF¯»ÔÌ†ø<sàeîó']MóO[@MfÚÛºßáÅûÿŽ:µ'¬w^llÔBwSyAàsí½ô±§ÃîqÍ±ø»NÀu0ôÃQC ÐÅQKÀ¾À,õEÁBÃµ0-õEÁBÃ±�ÎRþß:ó‚­AÈ¬±«u�Nøã´Ñ²§ÁràEçQ~È¿°çÓ‡ðbšï>P1üþQE0P°ïŸÙÆ/áç>ØNÐûÙÔš o¯ñ²µv ÖT«¥ø£ÂèÆm™jâ…§)M‰e¥Ø–6¦¦€ª˜iüÖ™Ú–suY“3W�ei³3¶æ)äl­àòÊ§\²Wø2Ÿ×¥³èÓvÿêÏ@'ÄîE¬C
ŒšDÓ£×`�7îËžõmQ�.ÑGÕšêµÕY°ûìö�Ó›‹zÛUIABùÕ�m£PT9²µû� ¿T`÷÷M²TQÊõ÷.µMH†]‚Üw».{ÔYµFt»EThGª×T	fÀWï°kÚ?Nn-ëmT$U7çV=¶ŒeAPæÊÔcî<t‚ýQ�ÿßÜA6ÈQG+×ÜºÕ5 hb»Þ”ÝoÞo¬Ô~¾æe+jÚ�w8VßK»¹Õ¹»»çØOÑqÏÃÇo<�|CcÃ�öË_yÛÔÜ-zò|O4Í�ÁÇì¼¸ÀLæþË<BBÏ³ç0?àPÜ×>qàpñ,|‰Ë¿ü÷Óà;Üîw÷ã…/àCtµ ³‹l?\#67ÎÁ˜ÿóŽ00ðëSpƒaÈ
¸4àzÓãÂ|ÿ/ãòß¨{®öYb!$¯Ñ”¤
ù�*ÎØŠfQ_é&&¢j%Yë›YV®ZùWÕoIå[Ñ¿ñik¥­'iUËÍb)¥(·’Ð¥ík¥­'iUËÍb)¥(¹Lµ¨©ßu™¾=ôôõÓ¿ÇÃNÃu[}ìgCOÛKÀpËLO(”0Ñê;bŸæ°Qp×”ãÀ¨Wpa»0@“b†‰q‡DÊ8ø†Þ”———AD¨‘\ÕPöòÐ`úã¤¨càÒ¦¾?=þð<£­×+Vó¿‹ç´2·ÇW]WÒëÇ„ú²©¨càÒ¿žìé$¤rÿ½ŽGØ[ÑOÄB�>¬ªê­UUZ™WŠ0ðóÀ¢T3±Â_:0¢÷ðŒÉ3h½ÔõYhffke¡Tå¡vyèâ^z<¨Ôâ†áP9¤ÊíÈú¨i1«r¦“·'¼i1«r†“· dª�0<?È[Pê0¤Â­Èyþæ÷C¯ eU?;08 `äÂYÂ›ÝÐ\ÐT]ˆMT=5PôÉU2Žª½�ï?þM·Ulsµ-ƒüteF}«ÿ�NþÈÎïŠñþ<éðgâóêïëLƒ:»díÎ$&í+�²³½Nˆ�Åÿò´ü|ã>›Â^lºõü%Ç¦Ïx4ÓÞ	tM˜�Â9Ñ+¡H ùyÃ�äQtš‚n3¸áOJ~°UD “ºÃWWß8$Â
ªŠ�M4iÌÑUPnÔQ¾¡º®|‡;H ýnX§_Z_Zá¤U{lMµa^5©­›A¦Ö}š¨UO*âXPE^ßÒ½�`Ôo‚l.1¯Ë×mg_šZ¿ìµVP¦Ô„Vßa!Ç…¼!T©�««Ñè­t==§;-µ[{6×ÕòšÚÈhÏ„ÄqYÌlâ•AÖ�]±c_ÐãÓ6×Yªß…´®¹gàXâªðÍ „—ØÛmœV:,CekËOJ’áöí¸—m ×9ú�b­×¸3l¿gS,ß†�Çi³ö¦fVÓob�j[0û«ò…˜;eßú&ž*bSGJ¦ŠØa™ª›¢5‰vÑ¡ÀôN4¨oÄˆ(v7gVWê·?ªVo)®Y\î«º       i  Ö  0¹  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  ;f<?xml version="1.0"?><Features nextValidID="27"><Feature recentID="26" name="sgRNA1" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="556-575" color="#a6acb3" type="standard"/></Feature><Feature recentID="23" name="U6 terminator" type="misc_feature" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="652-658" color="#a6acb3" type="standard"/></Feature><Feature recentID="21" name="AtU6-26 promoter" directionality="1" type="misc_feature" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1"><Segment range="107-555" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;&lt;div&gt;Synthetic construct guide RNA, complete sequence&lt;/div&gt;&lt;div&gt;GenBank: KT827739.1&lt;/div&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="gRNA scaffold" directionality="1" type="misc_RNA" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="576-651" color="#00ccff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;guide RNA scaffold for the &lt;i&gt;Streptococcus pyogenes&lt;/i&gt; CRISPR/Cas9 system&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="25" name="KanR" directionality="2" translationMW="30729.62" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="11437-12246" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to kanamycin in bacteria or G418 (GeneticinÂ®) in eukaryotes&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;aminoglycoside phosphotransferase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;aph(3')-Ia&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q></Feature><Feature recentID="24" name="BlpR" directionality="1" translationMW="20638.01" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="8650-9201" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to bialophos or phosphinothricin&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;phosphinothricin acetyltransferase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="function"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;Streptomyces hygroscopicus bar&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="protein_id"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="22" name="dCas9" directionality="1" translationMW="158203.57" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" consecutiveNumberingStartsFrom="2" maxRunOn="7409" maxFusedRunOn="7409" detectionMode="exactProteinMatch"><Segment range="2898-2921" color="#993366" type="standard" translated="1"/><Segment range="2922-2924" color="#cc99b2" type="standard" translated="1"/><Segment range="2925-5411" color="#993366" type="standard" translated="1"/><Segment range="5412-5414" color="#cc99b2" type="standard" translated="1"/><Segment range="5415-6998" color="#993366" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;RNA-guided DNA-binding protein that lacks endonuclease activity due to the D10A mutation in the RuvC catalytic domain and the H840A mutation in the HNH catalytic domain&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;catalytically dead mutant of the Cas9 endonuclease from the&amp;nbsp;&lt;i&gt;Streptococcus pyogenes&lt;/i&gt;&amp;nbsp;Type II CRISPR/Cas system&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="locus_tag"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="protein_id"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="20" name="KRAB" directionality="1" translationMW="7404.74" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" consecutiveNumberingStartsFrom="11" maxRunOn="7409" maxFusedRunOn="7409" detectionMode="exactProteinMatch"><Segment range="7158-7343" color="#993366" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;KrÃ¼ppel-associated box (KRAB) transcriptional repression domain from the human zinc finger protein ZNF10 (&lt;a href=&quot;http://www.ncbi.nlm.nih.gov/pubmed/8183939&quot; title=&quot;http://www.ncbi.nlm.nih.gov/pubmed/8183939&quot;&gt;Margolin et al., 1994&lt;/a&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="gene_synonym"><V text="KOX1"/></Q><Q name="gene"><V text="ZNF10"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="protein_id"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="19" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="10759-11347" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="direction"><V text="LEFT"/></Q></Feature><Feature recentID="18" name="pSa ori" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="10209-10644" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;origin of replication from bacterial plasmid pSa&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="citation"><V bool="1"/></Q></Feature><Feature recentID="17" name="Shine-Dalgarno sequence" type="RBS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6911-6919" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;full consensus sequence for ribosome-binding sites upstream of start codons in &lt;i&gt;E. coli&lt;/i&gt;; complementary to a region in the 3' end of the 16S rRNA (&lt;a href=&quot;https://www.ncbi.nlm.nih.gov/pubmed/7528374&quot; title=&quot;https://www.ncbi.nlm.nih.gov/pubmed/7528374&quot;&gt;Chen et al., 1994&lt;/a&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="16" name="rrnB T1 terminator" type="terminator" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="9954-10040" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;transcription terminator T1 from the &lt;i&gt;E. coli rrnB&lt;/i&gt; gene&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;Escherichia coli rrnB&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="15" name="rrnB T2 terminator" type="terminator" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1"><Segment range="9835-9862" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;transcription terminator T2 from the &lt;i&gt;E. coli rrnB&lt;/i&gt; gene&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="14" name="nucleoplasmin NLS" directionality="1" translationMW="1739.18" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="7409" maxFusedRunOn="7409" detectionMode="exactProteinMatch"><Segment range="6999-7046" color="#993366" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;bipartite nuclear localization signal from nucleoplasmin&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q></Feature><Feature recentID="13" name="SV40 NLS" directionality="1" translationMW="883.15" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" consecutiveNumberingStartsFrom="126" maxRunOn="7409" maxFusedRunOn="7409" detectionMode="exactProteinMatch"><Segment range="2853-2873" color="#993366" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;nuclear localization signal of SV40 (simian virus 40) large T antigen&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="locus_tag"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="protein_id"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="12" name="SV40 NLS" directionality="1" translationMW="883.15" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" consecutiveNumberingStartsFrom="126" maxRunOn="7409" maxFusedRunOn="7409" detectionMode="exactProteinMatch"><Segment range="7065-7085" color="#993366" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;nuclear localization signal of SV40 (simian virus 40) large T antigen&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="locus_tag"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="protein_id"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="11" name="SV40 NLS" directionality="1" translationMW="883.15" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" consecutiveNumberingStartsFrom="126" maxRunOn="7409" maxFusedRunOn="7409" detectionMode="exactProteinMatch"><Segment range="7101-7121" color="#993366" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;nuclear localization signal of SV40 (simian virus 40) large T antigen&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="locus_tag"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="protein_id"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="SV40 NLS" directionality="1" translationMW="883.15" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" consecutiveNumberingStartsFrom="126" maxRunOn="7409" maxFusedRunOn="7409" detectionMode="exactProteinMatch"><Segment range="7350-7370" color="#993366" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;nuclear localization signal of SV40 (simian virus 40) large T antigen&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="locus_tag"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="protein_id"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="8" name="CaMV 35S promoter (enhanced)" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="7928-8605" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;cauliflower mosaic virus 35S promoter with a duplicated enhancer region&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="CaMV poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1"><Segment range="9208-9382" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;cauliflower mosaic virus polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="NOS terminator" type="terminator" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="7451-7703" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;nopaline synthase terminator and poly(A) signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="Ubi promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="745-2735" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;maize polyubiquitin gene promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="4" name="LB T-DNA repeat" type="misc_feature" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="9532-9556" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;left border repeat from nopaline C58 T-DNA&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="3" name="RB T-DNA repeat" type="misc_feature" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1-25" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;right border repeat from nopaline C58 T-DNA&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="2" name="HA" directionality="1" translationMW="1102.21" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="7409" maxFusedRunOn="7409" detectionMode="exactProteinMatch"><Segment range="7377-7403" color="#cc99b2" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;HA (human influenza hemagglutinin) epitope tag&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q></Feature><Feature recentID="1" name="3xFLAG" directionality="1" translationMW="2730.72" type="CDS" allowSegmentOverlaps="0" cleavageArrows="2846" consecutiveTranslationNumbering="1" maxRunOn="7409" maxFusedRunOn="7409" detectionMode="exactProteinMatch"><Segment range="2781-2846" color="#cc99b2" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;three tandem FLAGÂ® epitope tags, followed by an enterokinase cleavage site&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q></Feature><Feature recentID="0" name="M13 fwd" directionality="2" type="primer_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="7712-7728" color="#a020f0" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;common sequencing primer, one of multiple similar variants&lt;/body&gt;&lt;/html&gt;"/></Q></Feature></Features>
   ±<?xml version="1.0"?><Primers recycledIDs="1,2,4,3,0,5" nextValidID="6"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  P<Notes>
<UUID>040a026d-3f29-49f9-97a4-3e4648a4b873</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<CustomMapLabel>pBUN6I11</CustomMapLabel>
<UseCustomMapLabel>1</UseCustomMapLabel>
<Description>CRISPR/Cas based plant genome editing and gene regulation; expresses dCas9-KRAB, gRNA scaffold for insertion of target sequence (OsU3 promoter), Bar resistance.</Description>
<Created UTC="21:24:26">2018.8.6</Created>
<LastModified UTC="6:35:22">2021.9.3</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
<References>
<Reference journal="BMC Plant Biol. 2014 Nov 29;14(1):327." pubMedID="25432517" title="A CRISPR/Cas9 toolkit for multiplex genome editing in plants." authors="Xing HL, Dong L, Wang ZP, Zhang HY, Han CY, Liu B, Wang XC, Chen QJ"/>
</References>
</Notes>
  O·      ¨  68        68*=fo‹Wxd©^0Ç[†õ;S”íÈpZS¤–¶ô-õ+�j´^5éªmAn¥vqtméRºáMzT¦ÐØØ Am�-öMÔt2ëžçÓV8ðx	Ê}ÈbRQ•âAM«$€öú´‰£I€ðý§5 q×Ty&’}ûovFÕ8jUˆÑ†ò„}H”ø¬+%8–5$ÉŒíÍx/Eú4Â	pÍ Â«`è¦*ª �.cì½M53)Ï ,b¡Š`M5Æ)Í4,þUÕ)]¶ Â<Rl{^m’ƒ-±3Û±|rŽ'j'óH0øSÝÒ¡¨à§|”:W\Ã¨mqú W¬:ÿ�1ï3‰·Ú(�Ç¶¼ƒ)½9LÅãZ�3Xvº4&ëÓÜlv†àæèáÕMD]“(ú	Ó^êÂ¾A¹¨C9XWés˜³ÏÇ€àÆ‰#§(¿6 �3I|5[3Å,ãÇ€ÖÏ�Òm?-ž…9› uQ³ û34m(Z‹ÞrFßP’ÃVX¹9¬­Oó¬Ã0é{S)ÞSvZ;tõy´-KŽ©¦ªS#e”ð»
¤NEdÔ¥YC’ò›^…Tƒ|Kêª«*�¡*»Ë6*4ªj¼ª6…jï.Ø¨Ó"µTœÓ‰«zjpÏv«cÊˆõæüNHYÓ ëw]à‡ó‡ã²~ÉòÉÃtÚ�iP"ã£ŽS¡›¾4�2ÂÈÿ»‘a6�‹”¦UZ}Ùªª-ÞŠ…#J››©�™©^§¹Å–e¹’yÖY´Š¤E¶eat¤v•Zj‡]¹Ò©º©"6"»êª£VN·æež¶ö©¤�½©¤
X*¦G–ª¤�¹ªkš¤û•¥yW¹ªJªš–Z‘™VE•eHyU¥ugú”V•Uåvªè«FXôø¥sËK—}}1}4Ë2Àõ1M7»‹8û�ÿ»+Î÷Ê£¼âÃoEc Á0ÑÈOÃC¾ûîÜ79À¾¯ß;ë:¿¯³óÉedwÿ½ßî¯õû"ŠÁ3wwuônÿÕ½ü°ß¼ëPœó²ûÿÿÿ»Ÿ®äl2¼/`¤ÂJç®+b¢)È¨ŠFò8äÊÉÜÇârÑÜ®9z="®ê [à;“ÊóG±«aªª*Ê6@¨*?ªúšµ™�#z*,n«cªª.‚ˆaˆ.
+‘°I¸«WŸ‚¦–¨‰ˆˆövkd§…``VlnA�™Ø¡Œ
§†6gDcªŠÎ‚ˆaˆ"
+k+‘°Ix«WŸ‚&¦–¨‰ˆˆ¶vëd§¥›�d&v(b©á�™Ø`Ù�6æ¶c¹~„Ÿ›še•Ô˜ªe¦¨n†g aƒf4Ó™ˆª“øúÙÎjj:	â®¨±ŽßâŠ‚)ë�? ýg¢`ó;‘�§P}Ç iÔqÚuaÔ`ïQD(6÷ �N8užÆÃìö€y{ŠÈmñÄ�B?µE+P¾]ñ°ÚöÔQnÚîø¬tÃÃ„9Ì;S7ÏÍ's4[6ãŸ�j»×ƒ(q®®½ÐàA-¯²eÜL6õºÃ]¢Ç£çÜE'ùÆçÛŒS²½Ñ”0~óá¹û;ƒ÷a¥+@=«á± µüdÆ(u8­½;#G'_NëEÿic-±ÌPæø¼ä;±K°Ï±á³ôãÀÄQEÃâ°í£;O€;sõëRÅ«³„õ8Ó»ÔÙÇ~_¾Ñ°ÆÒsâ¾Î=E¸°sÛï‹†k´]ñqC¼îÓïaµ3œq7ÛA¸¾3‚ÐÓNÿIÔºëK\9Îv‡îÐA+�JÛSÆ¸FÁã‚ílÄ¾SL¬eÃM¿wÑ­» N79¾CA®«íA—ÌEF¸z´òyËÞÎ@5ïÎ³ aüÔ´AmÏ ^± ±ÔäÎÒÊÛZ±Ô_�VB;ùMìï‰Äž·K�q8yB˜‡Ä„ðêø¸4QCÛ ~ø­G×ÁBÜ)M;PAç­E:Æ°±¸2„:×>þ ~}Æï…iA”¾\AfûvˆáÞÞâ±ÀFLøQéÏÛºÆBØSNÔA'|8 C„ÐS¶×¬SKÀQÆû¾L`ë1|Ö­�8kq‡O·kPA›ÑC´!0ô {8ÜM›1~ÎÏNmE k�!BˆNP¶Cu>vËhFÀE´}ÍE·1aD@ÚPN ¿FûPMü EÜÓ�NçâyûÑ`ó‰ˆA8¥Ðí1§±�l¯t¶¾{Úuíô,EðK†X¯­BÊQF^x3Ó¾=NsL¬eûuC„@0;¸NPÀëmD4à±ÃFÞSrŒÑ®Ç·yIÆaÔá¼Ä!BÛ…-S²ï´½+�B°µÖŸ}�Øs'ás,7NáµŸÕ;1+"p�B§„a³Ô°Mh5|õ'®¹î]¦®µ·¸=`Äo3ÿ¶ÄqpÄp"Ô«1òÐP®ïcÝHY²ÔQÑÑàÀ®åµ®>SÓNÛ?5¼QIÃ±ÓýâžÂø(ƒ(ERõíDÈPN8·`LïN±_ÆÆ¯�P9Ô…†ÚS¿ÔžÞë�0cƒ¯818Ñ@ƒ¸òõ&!zûŸƒïÞqí@ÓüA×E4â²ÄÓu6Ÿ±Äm¡4jñ+½LÈoƒÇ1nP¾ï2uÔß1Ôõ´Ðám­»­þ_°Ïøã«RzÇuæÆÍD'u7”¾1þÛßK|>çÌÛ‹´ì ÇSL1Å0QE¼ìÏTQL,;SßTQL,;å/íó O7ø!ÊÔŠË·PHï�Þ;M*|!Ž^uì‹û}8qO)®óàEOÀ¿åSùýœbþsí„í½�I ñjÿ+WjeJºQ¡oŠ<.Œa¦Ù–®(Zr”Ø–Z]‰caÊja
©†‘/Íi�©g1‘WU™35yV›30‹nbžFÀZÞ,ªuË!àƒ)ýz[>�7oþ¬ô|NäZÄ0¨É äM:=vqÞì¹ïQfÕÒí}P9¡«]P%›_¾Á¯hý9¸·­µPt‘T ß�XöÚ1•C›+Q�¸ñÒõFÿqÛ UE¯_rëTÔ�¡ˆeØ MÇ{²ç½E›TgK´Qõ@æ„z­u@–l~û½£ôæâÞ¶ÕAÒEPPƒ~ucÛhÆTl­F>ãÇH/ÕýýÄl�Ur½}Ë­SR†!›½áÉ@aÍÖýæúÍGëîfPR¶­¨s…mô»»�[›»±.}„ýü<vóÈ÷Ä0v<0¸ßlµ÷�±MÂ×¯'ÄóA|ÐH~ËËŒÎoàì³Ä pÄ,ðÛ>sþÍsçÇÈœ»ÿÏ}0p½Îç~8Rþ7@ëQ28¶ÀãõÇñ23cqì�ÿ0Øãµ7x6€«ƒN­><'Ïòð¾?-ñ‡±*ïe–"Jý@Z@¯™¬íˆ¡6eþ’bj&¢Už¹µ•jå¯•}VôžU½ÿ–°ÊZÒv•\¼Ö"šR‹y-
^Ö°ÊZÒv•\¼Ö"šR‹”ËZŠ�÷Y›ãßOO];ü|4ì7U·ÞÆt4ý´¼´ÀDò‰C£¶)ñŽkyN<
…w³	6(h—tL£�ˆméIyytJ‰ÍUo-®:J†>*`ÀËãóßïÊ:Ýrµo;ðÁ¨¾{A+|uuÑ•qPý.¼xO«*š†>+ùîÎ’JG/ñØä}…½üD(óêÀê®ªÕUU©•q¸£<
 5C; 5ó£
/p0OÌ“6‹ÝOP1õ–†ff¶ZNZgžŽ%ç£Á1 Š�N(nšL®Ü�ª†“·!úi1«r{Æ“·'øi1«rJ¨ÁSü…µ£ ÚL*Ü�—Ÿîot:ðUSó±ÃŠ nL%œ)½Ñm eÍEØ„ÕCÓUA|•Pó(àÊ«ÙóÿáÄÛuVÇ;RÑ1_ÇAæTgÐÊ¿øïìŒîø¯ãÎŸ~/>®þ°È3«¶NÜâBnÒ°‰+;Ôà8ˆÜ_ÿ+OÇÎ3é¼%æË¡/_ÂQÜzl÷ƒM=à—A¤Ñ1	‰#�º‚—œ9ÞEI¨&ã;Žô§ëTJ	;¡¼5u}ó‚L ª¨¨ÔÓFœÍUíEêªçÀ¸s´�pÖáeŠuõ¥õ®EW¶ÄÛVãZšÙ´mgÙª…Tò®%…Uíñ+ÙFø&Âãñì½vÖuù¥«þËUe
mHEmöx[Â`ÕJ˜Úº½Š×CÓÚs²ÛU·³m}_)­¬†ŒøLGœÆÎ)TiÕÐ[5ðÍÞ=3muš­ø[Ašë–~Ž*¯ lÒI}�¶ÐIÁ•c¡‚ÁD6V¼´ô©.nÛ‰vÚsŸ¨ö*Ñ]{ƒ6Àëöu1‘¢Íøhüv›1?jgöem6ö(¥³±Ê¿(Yƒ¶]ÿ¢iâ¦%4tªh­†š©º#X—mªÜDãJ†ü@ø‚‡cvu`qpe~«sú¥fòšå•Îê»¤      67  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  <Ñ<?xml version="1.0"?><Features nextValidID="26"><Feature recentID="25" name="KanR" directionality="2" translationMW="30729.62" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="12843-13652" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to kanamycin in bacteria or G418 (GeneticinÂ®) in eukaryotes&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;aminoglycoside phosphotransferase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;aph(3')-Ia&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q></Feature><Feature recentID="24" name="BlpR" directionality="1" translationMW="20638.01" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="10056-10607" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to bialophos or phosphinothricin&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;phosphinothricin acetyltransferase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="function"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;Streptomyces hygroscopicus bar&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="protein_id"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="23" name="SmR" directionality="1" translationMW="29234.10" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="823-1614" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to spectinomycin and streptomycin&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;aminoglycoside adenylyltransferase (&lt;a href=&quot;http://www.ncbi.nlm.nih.gov/pubmed/2993813&quot; title=&quot;http://www.ncbi.nlm.nih.gov/pubmed/2993813&quot;&gt;Murphy, 1985&lt;/a&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;aadA&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q></Feature><Feature recentID="22" name="dCas9" directionality="1" translationMW="158203.57" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" consecutiveNumberingStartsFrom="2" maxRunOn="8815" maxFusedRunOn="8815" detectionMode="exactProteinMatch"><Segment range="4304-4327" color="#993366" type="standard" translated="1"/><Segment range="4328-4330" color="#cc99b2" type="standard" translated="1"/><Segment range="4331-6817" color="#993366" type="standard" translated="1"/><Segment range="6818-6820" color="#cc99b2" type="standard" translated="1"/><Segment range="6821-8404" color="#993366" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;RNA-guided DNA-binding protein that lacks endonuclease activity due to the D10A mutation in the RuvC catalytic domain and the H840A mutation in the HNH catalytic domain&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;catalytically dead mutant of the Cas9 endonuclease from the&amp;nbsp;&lt;i&gt;Streptococcus pyogenes&lt;/i&gt;&amp;nbsp;Type II CRISPR/Cas system&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="locus_tag"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="protein_id"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="21" name="gRNA scaffold" directionality="1" type="misc_RNA" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1766-1841" color="#00ccff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;guide RNA scaffold for the &lt;i&gt;Streptococcus pyogenes&lt;/i&gt; CRISPR/Cas9 system&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="20" name="KRAB" directionality="1" translationMW="7404.74" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" consecutiveNumberingStartsFrom="11" maxRunOn="8815" maxFusedRunOn="8815" detectionMode="exactProteinMatch"><Segment range="8564-8749" color="#993366" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;KrÃ¼ppel-associated box (KRAB) transcriptional repression domain from the human zinc finger protein ZNF10 (&lt;a href=&quot;http://www.ncbi.nlm.nih.gov/pubmed/8183939&quot; title=&quot;http://www.ncbi.nlm.nih.gov/pubmed/8183939&quot;&gt;Margolin et al., 1994&lt;/a&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="gene_synonym"><V text="KOX1"/></Q><Q name="gene"><V text="ZNF10"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="protein_id"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="19" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="12165-12753" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="direction"><V text="LEFT"/></Q></Feature><Feature recentID="18" name="pSa ori" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="11615-12050" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;origin of replication from bacterial plasmid pSa&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="citation"><V bool="1"/></Q></Feature><Feature recentID="17" name="Shine-Dalgarno sequence" type="RBS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="8317-8325" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;full consensus sequence for ribosome-binding sites upstream of start codons in &lt;i&gt;E. coli&lt;/i&gt;; complementary to a region in the 3' end of the 16S rRNA (&lt;a href=&quot;https://www.ncbi.nlm.nih.gov/pubmed/7528374&quot; title=&quot;https://www.ncbi.nlm.nih.gov/pubmed/7528374&quot;&gt;Chen et al., 1994&lt;/a&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="16" name="rrnB T1 terminator" type="terminator" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="11360-11446" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;transcription terminator T1 from the &lt;i&gt;E. coli rrnB&lt;/i&gt; gene&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;Escherichia coli rrnB&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="15" name="rrnB T2 terminator" type="terminator" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1"><Segment range="11241-11268" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;transcription terminator T2 from the &lt;i&gt;E. coli rrnB&lt;/i&gt; gene&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="14" name="nucleoplasmin NLS" directionality="1" translationMW="1739.18" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="8815" maxFusedRunOn="8815" detectionMode="exactProteinMatch"><Segment range="8405-8452" color="#993366" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;bipartite nuclear localization signal from nucleoplasmin&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q></Feature><Feature recentID="13" name="SV40 NLS" directionality="1" translationMW="883.15" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" consecutiveNumberingStartsFrom="126" maxRunOn="8815" maxFusedRunOn="8815" detectionMode="exactProteinMatch"><Segment range="4259-4279" color="#993366" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;nuclear localization signal of SV40 (simian virus 40) large T antigen&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="locus_tag"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="protein_id"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="12" name="SV40 NLS" directionality="1" translationMW="883.15" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" consecutiveNumberingStartsFrom="126" maxRunOn="8815" maxFusedRunOn="8815" detectionMode="exactProteinMatch"><Segment range="8471-8491" color="#993366" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;nuclear localization signal of SV40 (simian virus 40) large T antigen&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="locus_tag"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="protein_id"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="11" name="SV40 NLS" directionality="1" translationMW="883.15" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" consecutiveNumberingStartsFrom="126" maxRunOn="8815" maxFusedRunOn="8815" detectionMode="exactProteinMatch"><Segment range="8507-8527" color="#993366" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;nuclear localization signal of SV40 (simian virus 40) large T antigen&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="locus_tag"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="protein_id"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="SV40 NLS" directionality="1" translationMW="883.15" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" consecutiveNumberingStartsFrom="126" maxRunOn="8815" maxFusedRunOn="8815" detectionMode="exactProteinMatch"><Segment range="8756-8776" color="#993366" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;nuclear localization signal of SV40 (simian virus 40) large T antigen&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="locus_tag"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="protein_id"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="OsU3 promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="164-543" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;Oryza sativa&lt;/i&gt; (rice) snRNA U3 promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="8" name="CaMV 35S promoter (enhanced)" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="9334-10011" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;cauliflower mosaic virus 35S promoter with a duplicated enhancer region&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="CaMV poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1"><Segment range="10614-10788" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;cauliflower mosaic virus polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="NOS terminator" type="terminator" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="8857-9109" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;nopaline synthase terminator and poly(A) signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="Ubi promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2151-4141" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;maize polyubiquitin gene promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="4" name="LB T-DNA repeat" type="misc_feature" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="10938-10962" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;left border repeat from nopaline C58 T-DNA&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="3" name="RB T-DNA repeat" type="misc_feature" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1-25" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;right border repeat from nopaline C58 T-DNA&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="2" name="HA" directionality="1" translationMW="1102.21" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="8815" maxFusedRunOn="8815" detectionMode="exactProteinMatch"><Segment range="8783-8809" color="#cc99b2" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;HA (human influenza hemagglutinin) epitope tag&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q></Feature><Feature recentID="1" name="3xFLAG" directionality="1" translationMW="2730.72" type="CDS" allowSegmentOverlaps="0" cleavageArrows="4252" consecutiveTranslationNumbering="1" maxRunOn="8815" maxFusedRunOn="8815" detectionMode="exactProteinMatch"><Segment range="4187-4252" color="#cc99b2" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;three tandem FLAGÂ® epitope tags, followed by an enterokinase cleavage site&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q></Feature><Feature recentID="0" name="M13 fwd" directionality="2" type="primer_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="9118-9134" color="#a020f0" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;common sequencing primer, one of multiple similar variants&lt;/body&gt;&lt;/html&gt;"/></Q></Feature></Features>
   ±<?xml version="1.0"?><Primers recycledIDs="1,2,4,3,0,5" nextValidID="6"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  O<Notes>
<UUID>040a026d-3f29-49f9-97a4-3e4648a4b873</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<CustomMapLabel>pBUN6I11</CustomMapLabel>
<UseCustomMapLabel>1</UseCustomMapLabel>
<Description>CRISPR/Cas based plant genome editing and gene regulation; expresses dCas9-KRAB, gRNA scaffold for insertion of target sequence (OsU3 promoter), Bar resistance.</Description>
<Created UTC="21:24:26">2018.8.6</Created>
<LastModified UTC="6:35:2">2021.9.3</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
<References>
<Reference journal="BMC Plant Biol. 2014 Nov 29;14(1):327." pubMedID="25432517" title="A CRISPR/Cas9 toolkit for multiplex genome editing in plants." authors="Xing HL, Dong L, Wang ZP, Zhang HY, Han CY, Liu B, Wang XC, Chen QJ"/>
</References>
</Notes>
  àý7zXZ  æÖ´F !   t/å£à¹¢ž] Ë‡ØÎf‘ƒÊý{3Ôé·Ú(1v%f M*	mj÷)p80çÌ*iÚ	´NY]Qó“�úF7î&ƒÕ!Ò÷ÀnÆVß1õUaÛÎJ¡Æx_fOSF÷ËE²ÀÜBw¿¨~ÖÇ­b¡8Ø>y`u@Û×Ñµsm£^<yé‡Èì9ÎÎ=WÏAtá\\­‹.O[SÝ×*0¹�J.%„UØ
±@:©â|ñeDÇ“9ïòM
lD�#9úÝ²B›IjýFX]µ¾• § }ÙPZkÖ„€`ŠO½Ïª±ÛU`�¥ÿPÃ¦o’×T‹ÿ»$»šð¿vû`%ý¨¯‘a+�˜Á[êõf
ÚùÂ°œc—uÍÌgJÊˆ`sV5¢µÚpBo^ÛË‘6\„uán
²2UE
õõ™�Ç6€Í"X•”5ó{¶…ƒÙóÓD‘Sq"{Ò@2®Æ(	Šçíñhî±ØgGÄ*B0_Šœa-8×óøçY¹Oÿå¼ó;…9I†Éï«=ÚTkU¾œœ;<‹õÈž9ü2–G˜rÉ©c¤X²õ¹Vƒâ–Ý«$í²OP¾�Áh<£zÃp%“ÞÓ¬Ö�´÷‰ëû%³žCyn‡L%Qü�%å\Þ›÷¤þ•<€r¿§>šo<­©©·«`fíÒæÊöw÷ŠlÆPà[ý„‹ºR×{`‡�K°&­ì>ý#¦Y.¾KªXlÖjLCW5½Å6·Æ
´ÊB¶YË-Ùà1ýk Ùg	¸Ç_:ùo‰b¢ò[ÕQ1b¢|»Õ]íùýâ	-K:ÝÎßEÁ°Øzˆýêr³ËBàÅ QHÃ¨ô¿ÈL‚v÷uÛM¿@»¦Î]l'O³C_8ì´²XœärœœW‹’ê$Ý³ŸU)ˆûÈ¤=»˜BØ"pŒK³œ€WO2Þ¨�ã�úeç\¹–†ÇW®è�¨1Las•j1	êËôväÜØ7 é	o“ŽlÙÖ_�ØNë¬/øøÂ£aqgÍ"×€IUuHR~¯-qfrmT½ÈwÀšJOô_}|ÆÓÂPwº�cõõ¢û/y9•quü¡9„]–È„ÿ	Þ7˜(—€2ÎC–LúÞØ |?Úð1¯žW«C0ØÆ¸}w–L²d‡%u4±½æ÷þD¤Èx 78eT­ké‚ÕÝeÊŠ4è–¿ZTîý5Ó£! 5.ÐÕ·Gmq¿–.)­+œAC§¦W¸Õ“Ý½Z2ø^ˆ)¹ˆxrí|@
#yõm/€ã�ZCw2M>PTÊZÛÄ-ß®ú(L˜ê£G¾?z"€fzU.5J«NdôœÄó=Q8¾È£ÖÛ£BÅ\Ó½Áþ³3°tè“¼Íò‘sË�c-7 ±•5­˜|û	Â�k‰0oLSÊÝ¿%îÓŠÙ{Ð)µGÍF‡0ÖSù„££¶R(e9p+e‘ý|Ñ#™©ÒLÕª´´‚KÔ/Z`#~Ë�r¦»(sq­`ô{Fk¾È˜ñ¯Mæ)‚wÅ´ÿ©”Oû»”;åÉØ™}åp1¢w.�5f-ò2,j'9{’bÌÙ…»ÝØ{Ÿ]éþjˆhÃ¤,ƒ·*ƒ9�ŠâŒç 1‰J\û"†ó_î\[”5.ðÿ1¥¤ì¹ ¡r
1‘×)wä6KdÊ1�¡u¤"�ø«�¬ÐgX Îtš´ÝÖ[]Ž�ýsë×ÕxlôË½/ezÚÄUÑèÎœvy€¤j?è}®{ã+þõ•ŸŒß$x/ÑûUôî´Äþ¾›å8€ògl™×»9æøãí?‘ÿ27,1Ã Yos#\¾mV�¥*í
ßµ3;ÀÛó SøGT½¹³æq1«"OBŒ®ÓrLå§B¥œw$èÒµæè™ãÉ~#¡–€ªmÐi�¬¬0Ò¥�Ã!eOÈXY¼¹$–áÿ²ä,üñé”º÷«•ÚX�¹2�ïÄ®ýåkä×ø¦Ñu.C>ÂòKAí¥¤ÓEc9•ˆ=T¢ký}!Ók®<Éa«d¢G”ö¶VÐ/ÝÕ2_¸bÄÌEi ÊF`‰5áöBY®°ëò÷A@jÑ_Q™¾\¬o\®‘2†NŠŸÌÛVÁà	¦Öð-.Vdí°fLç¨M!ŽuÿÏüHks£gÞ{$˜•~hÏpñ¯Ï[N”�CjaÁÎÅ‡SÇbQµZËÍžÕz\lÞó
`u,–ÂŠ½„o„:±Sß¾°á}ï¢>b`ýËùNí1Î-lBöz…Õ™´ä¨¼ŒêÌ/i«YOö�Ò Õv«x™Ó,ÀÍWþÇBU‰šçVÈ•6Ëª`F DÏÏOŒTõ]oì ÿ*;�hÉàUÝhçvQæN¹¶wêÀ±‚1P‘&PìÌ‘i'µv-oç�œ‰¬)õÂÄ÷ÔÍÙ'L¦ÔcYŽU5¦«‘iÇ1?˜§êû›hN‰ÝbT LÔ,ïˆ£­öÀÄç}`eiu{«fXGšâZ‡Tp(su¦•ßhæº5ä��jUt
€}RÜxã�ø‰lh|âä’EW ðª{“ÉA@>d†å1½…Å‡Z› ]Î „õþS­¸=…#ÒÖS2}®Çý×½r~žñfÝÝÆ$pÝÐ[DìàÇ4z°Mu
MÁŽœ¦�TÄÎ‚¬k5ƒ'Eäð¦,Qî_àCÁW³,‚4 ’ÉI—å€ÞHá«¼lÙ´ŒôÒ�uZ#ƒi¼³'„Ý6P€ÈžN7|Ù¤¯¥°IÂ¦¨ƒœÝÒô+Ùð_fŽ‚ç»Ð"Is7lØr_ÐÐ'€ÄuÍÝœq'ÞHˆÅWœí›.MŽÚ[ZÎb?öO8qùŒ‘a"4·×¬Ádóé“Ì@/Óá¶gc:èˆšè˜çñäÿ|û¸™+È€ž­sÓê¨Óüìb®mÒ^vQ ‚53Vñ9Ú¨²…>ÊGm++�ê²õÓ~L²él¬¾òdEäË ƒ4»âÒ'xýÜôŠW¼&µ&d­³R�í(”L¯ùèÇ0[ñ<¬Ûšˆu“Ã1Ž¤ºˆH;HN)áŽkJ• õ¶áj{Í®*vÊ‰<ÍdþÞ�{$Ñkðž–d<Ö¦ú6š@’>qÍŽê
÷:¦„ZÖY†â° à¸<ÍBÏ×Ê:kÔÍ"s>©œ“}ÙØ.±*ÞO‚Ú&‰à:o§žÀí½4Gæ�×àÎõÉT&òûo&±Ÿ40“µ05D™úÕ?èÚØv@½œ)¼1ÝÊeÙR>¬éa»ƒƒÏ¦ó;ù*q¿ÃÕÕ
#kLFhÇ"H˜Ô½g�ô}Š´[E³75·ä½‰MÞ¿®}ƒÓ?{gÓÙ‰È<u3ô²ä˜Hœ$'çîœhÕ[¼œÀ ü¯:çâLãíXûž6Q"g!ä‹Ùs¨r�>1ÑêÇó2CrìÍ;GþJJÉÓ—�£�oö«&K4?”	þÉçDï½@
‰G�_ÚÅù—FËÕ3´} .›'’€ÜˆR‡i…™H!˜*/ï$ñH�ñ�ÎÕ“L”D[3•Í€eß B…û»<Ýî;>RÌY=TNïÃBÛ›W³ÿ^¢þ†RŒÈ¶ØÓ;öŒA‘7¤©õa•V õ~	d\ôUù°¹ö¼ÁzCà’êÌ²ÒÑ’é:b¶"£ul
Žx²¼gS1	¨ƒDÌSün½ožR˜ƒ£PäTÖÖªN´)	ãÒ¾ŒÎ—'‹6EœÑº®/¡�Qžä|?½Ž$’ƒˆP0aÏÂ¦„25dEnYâywðH–n«~æ…‚ƒ*À¶[ƒ›(v\›ÎÐ…Z¨ãÍ}ª ƒ²�ðÒû§ÁaeuaÝvö$EZÕ�^ðb&•‰A‹¹ÄØsä^‘wç‡B°‡Â.[¤br${¯¤|ÃP}éfß�n«xoµºÑSL�•	Î ¦µß
SÖ–qæpÊ”ÿù)$·t$šJ ¢ª¹ëÉëT{¢û4²V*ùÛqÔüã¶jÑKÙañd¡VŸ‹<Ùõ‚Ny/Þ¿ ŒXksp˜é2—ÔzÇE~…i$ÑOü§ç'hÝJÝ€bMþˆw¿*Ž¶wÒ FL?\¬cº@Ä±6£ ‘þðÎ Q%Žøoç7·c)ÄáMË¥ÕŠbDEa>ÞîwK’U–Ù„©CÂè9H¶Ÿã¹CCÂ•c!@ëŸF¼Š�Ã;b�qŸ]£ÕÎÈónqWgO©1})´1ëø]Y�Å¼cZÅÕuäWU(ñ€,'Cþ
¦ÚæÐË[´i#hªi³åªšêÍèR¼Ú‹‡�j“""°�-'îø|†��ŽOŽL#¶�‰È1r2gÜ[OðÑÈâ4‡ˆ·eÏäfH×;à…ôVÈU (O$+ÞØ†9Á$E‡ÏH:JAÇ–î”žˆ¥ƒ“Qþì=«Cl4Çä×¤&uÐß#:<†b×­Wžò¯ëìÁŽ¼#6è&«†9Ž2µ øÓÈeÈWêo(ª‹Õ®4üPì™l+ØŠù÷0{s¸vN8Ì©Ÿ¹d¬Ïº£Y¨d†¡�%P•»¥Øgõüf�œ�P2=Ä¬´béÌªŸ¬ó»B¶ó“Û„�$¿õ þžTõhî€4 ‘HÐöýÓ:R�…‚Õç-®Ÿ¬‘}3ŠF{9^šbâÁÀ*Ê/¾èè²‡Ì›Ö_B¯Yó&{îDÆ•fO_Û#²æ‰¾UwáðVC3¹�ÉÄriÐ4mØOdC.Díe.vØ/¼}wNjk”‹òa}C[ó"ŽÇ
öuÈç‘:Á†¹g‘$¡‹Ë`ˆíŒ‡40êíê1+ ÖM?
™³qk¢Ë:]½G/YxUtR¼¾¶HQW`VZðÂ–ù®JÓTr†ˆ‡K5ËªO¼|vO\§rA‚9jã½ÒåøÌ>~JêEÁ<J·Ví–“¢úA‹v?&´­\ ÍŽíÝMo´¤ëÔ„óÇ»%¯MszUjjÚÔŒˆñÂ
p9×z½}
ùê+¡Ô¥Ë¦³%Â×ìW†óå¤†6·HÒÝ‚éŽ]åF³Æ2k>a��¸c¸Ì+ÞŽ¯©åRH=ƒÅ|\­X,vl�w¯oÝbfŠ?®°îï 8BÞH`bÊY<ý˜e)vŠÃª*V¸ŒË$ÉÞ5¥è.Á/¡HÊý3ŠlHoM=ç¥<ï˜¨˜1œ3¶|=•—õ¥XU0f`]ï¼bm»þ-îŠÌ5w·nT„9ÿ:�Ê†Ñr$<QðtU´21î·G¿qÚ>œä gð`ÉJÒƒúÇ7€æ¦ßv“Û.²æ”»M�Æ‡ E^ýRFu¿3úéÐzÑ¾ÉÍ�ÖûÀ÷/ÙBdH<¶º±T�kzÎÿ�N¬:g‰6ë¦Ææ
}øœ½ªò[Q%²hÁt ¾Ç3û™,°…ð'Ì�x´Ì-�·ÏÆ#ñ²R—¦˜ñ€'$s-B[²ú¡¹ÞmƒJûh·fÖ«¹e>Zw¡ü©é_šxyèš„ÿ‘IL{¿+�/6õ )Ö¨Ry‹’•/ï:ÉÎ_¾ô¼�éyP•±)vƒ/Ì�Ä@9€£ü¯ÈÏ¦Ï*w½™š×’½¤þ¬Ê=‰ß�)½‹Í£ëÂõ    ¾ûG¨åÿ/ º!£ó šûÏ^±Ägû    YZ  Iî      Iå®ZTR

SMP4      D7†q  xÁK¯®[zäû~Æïñ;Ì9×Z{ïÚ.Ç®í2&Á®*G¥âr„„(;¡	ÑJ‰C€6$�K€JãEÐ¥M‡_€D+D	DDÃ…ãª½×iÎùÞÓã¹¹.þ­ÿ˜þBmßÇpl›cw8t�ß;|Ùþú¯}ïíWßÿÞ—Oßüæ×oã«¯¿ùÁŸþð'¿þS‹Ÿþ`j¦ˆ?�~
®:ýÃtÆÿ3�øþ·ÿø§ÿï·þÏ>}ûíû_üñÏïÿò»ïÞ¿Þ>¼>ß>¼Îûmž—\¼w?Çÿ
ü)þOÄü	~ñï¢0Z•C�’"@H$“‰S� Š"œ@§"tÐ!
¢D8$:Eˆ"LA§Ÿ¢ÜáN7
@A55!Ð)ˆ�ÑNN	N'�FÒh¤KµV¯‚@£RpH)•òJ7J¡Älæ€(
 D‡äp‡@FèµÖ¢ê (Òr 04žŠe+UÕiHb*V]^à�(‰pè!‰ÕÜ(“ÑPQ!�FyA• BÓ_…XS‰ÕR4«X£{4¦ÊÔAt±X3 Ùs.n‰	�ƒÓïB¨ÊRúä¨·mVhÌ¢ *s7oâ1r¿oKj,s2œÖõ©Íùº/Œ!$×ô»TT[Ô\k€ä6�Pµ!·MÛeäë¾)±êôÇUU±	Q;rTÃ`§ŸAŽµ6¬ùx®ÿ”ã|ÜëôÛå%ïšdû‚i>!
žsd{è›—å~³t8tq‹Wÿüh	2Mß@<çàÇá.ósFÚ
ò\¬iÝ=¯s.šSSÕwóÐÅf/×²zj›Î¶zÛrlC¥¦ß† åšy<G¼Þ^xnºF4}	�•·Øž�yy}^»¶�‘NH»ÃÚcßÌë¶Ä.ZtPÓß‚ •M<OZïvÃy&AÓ�! ÚWàÝCÇýý§õ<©(púE/…M÷Pý¶Í[7˜UƒOàBw:—ëý¾6cR4}(v~|˜×—;öCÛíÄR…‡ó8n÷Û|èÇ¾:¡é'm¥±¡µµÜ=v‰¸ ±{w®/—¾ëû§ï—ç{Lý9ÓY�ÓÉà÷m9¼y€}þpƒNç‡º]®ŸÓ±kiú ÅïÍãðüí‡}hO!ÑµU6CHËº”ãé`évÞsã¡©ËvY×H‹Çƒi¾\s`êÎMÌëýyÇ`§±a¾¾\�ýñ[}¾)]� i„@/{µöx¸”ëê]ê� Ÿ¾‚dð5×ðæëîß}¼áé¡ÜÅé@ 3rÓÍ²¬k¶¦£>ýD±ÊÍu+3Ò¹y öÛ­tÖFðé‡ åuÃù!Í///ûS:Xvs£Ï!ŸÏ}\–ÛÖXìŽOÍ^Ÿ×ŠCàÐô=H†º–<¼ çkMãØUÁÅ©ƒ j_…ó»÷�ßAÝ¹U¦ÄéÇ�È²ç2<µ½þê¦¯NTèÆé7  ÊKLOOÇëýÓg„¾;�ó2¯Ú ‡¦ŸA}ñýôøÔ]¯/Âm_§ßƒdòÛbýÛGÜ?\·q<ô\Mâô#¢/¾ßu¹<¿ÀâØöÍ¥Þ_+†áls~^DïÇ3üv»slG7‡4ý˜QšpJiYW÷±IàÓ— •ûŠñô°ÞŸ¯ŸNB� WR¿øí¾›§qLå²\¶½mÚì†J y­õôÅˆ�ÿÙ‚ï�îëv[_|øôË�Nk)‚¦ßƒÀê+úáÛ¶×j°c3ú6/›[Ý§ .I§Ô­ùZ
N!²JÓÉP–¼Þžû××O×ýéØc£ éÇDåõîoŸŽöúéãýpƒ¹8ý&@åÆî|~È·×o÷vbqBÓ�! uµØ›ºÝ>ƒ±KDÕ…vxjºÛ|Å:ô‰V ¡nJãið2¿.–úfà÷ËË¶è»{y­Kšà>}�µ®ÆÎ}]_1Ä�ª¨éA2”¥ÆãÓC½½|(çr@Ó[`õkðóñ)\_¾[Ðºq´5¿Î«¥>z€O_A |[÷ññ|ýŒ—¦ë"š~7WÙKí¾xBùø>/oOCµ"jú› _kÞåÏ×ÙŽ±y°ÞŸ¯5¾±±YÊ¶Œoß4øüá»™Ç‡¸£JÓß…(V9Ã±–ùîj†¶ÛöùºàÀA¡PÓ— _ÇÓñ°íÏËëC‡�º»¿`ShÛC¯<¯Ù¬1°RÓA k½”òåñˆË‡ç[|è;G ßrhÇ¨ûrµv`[M½.1G¯ûu…3uJ—ýÓ¢¦é‚(¬e‘Þ<œxûôí-çá)ôšo—åˆq8¡Éëå9ÇCÛpŠ�¯ÕãÃ·åzpê+ Ÿ`Í+Âùíãº|þ´cMNhú/!ÐëbÖŸ»À×Ë]±i bõ5�q¾¾Wôãàp™êba<õÁ¯—)Åãƒ|»n›£‰‡¶õýþlql#	Ÿ^!ŠÕ]ÍØmû|+è»+€U¯xøþ÷÷¾ÅðpZ3]š~¢X<‡ö0öër™›Ðö&Â§ÿXŠÔÁÛçoÆáñè[½|~=¤¶�¥^·ñüõ1|úð÷Ð=DDM-DQ{®ÝáÝ›íz¹}°¾é+ Ÿ~^wG3Ð–|Ë5$»ožÞžtÛÞãÒ�z'DMß@ JYWg\¯jâØsãõ~ÛÕµ0A}ÛVÿúñž?}{Åñáp|4Ý//š.Fj Š^¶Ýú·!ß^–BúSJK¹¿®è[³ôE÷æíã>½|{Å—ÃAæ¢¦¿ô¼mûã»·e~õø8ô¢‹š¾€(ìê1—[]Ð6cÛnë}ßBLM°BM#DxÝ*Ú¾á¾ä»ƒ©íl¯ë¶8ÊáÐõËrû¼�ýÑL�O?ƒ@ùVJ=¾4ß>îÕÓ0öàüº„ãq0S¥¦¿	�ªåR¶ÓÃˆýùóÚœ‡.dVjú=ˆ¢ò¶Zÿæ­]n¿E×ž†sÈe{-îÇd}!ÂËž»pò¾Ì›k4«¤O¿�^—¢î±?âõãKñ7ý�ÚM×íR04˜OXóvMý×g}zù°§¡Z Ýú!„r¿í[êŽí9ßî·lè:KÛ\^Û.A„Oªæ9·Ç/Æ­¼ÿ°A�£¬R>î%ÇÓã9®÷×Cw<Åp[ç×6÷{„ùzÛ*».à¾Zh‡êRë–Ò0>„z»\vK]`.êRSÿæ�ËûOÏkwìzÔà‚ö‚¶?¸Þ×<œRÂTßÛŽ{^ì–RN=4Ï7�ÇCŒ{~Ýgt©?ÊÛç™]Ó÷ÇÃþzÍvˆ}…š~QT™—½{{nìòüñ:ícßwØ®û•)µÑ§/!ÂµšwÃ¡º>Ïí!G:æûë-átè¬Ûòm…Ç6äÓÅêUÇîÁêírñÕš¡íòeÎµëúŽÍ¾í/¬!†¦ÍÛËë=§q<„4oŸç8†!( u){÷Ô?áó§Wžº7­…åþñõõ|l»â$�¹¬Ÿ¾HÚ>¾ÿx?žÚ±î·ûÇµ´‡c;lu»\ïs<kýº]R×�¢‰>õ!/7+‡wOÃòú>ïx8��„õ~›‡fèOïûe¹¶80¹M_A„ïÚ`�”õuÝ1¤¾
ôé!•¬È}_–Í,uÝæu+‹3F˜P]³âð4–ÛÇW¤Ãé0–P×u+qHÇcòm¿oî¡;�Úu]^/#–§¯!•½i›TÖí¶ÖÚ7‡°äu©}“àœþ9ˆ({©±{jÃëü\J;6-	ÀËŽÇcÚÊË¼–¡{°žy™ïÛÖŽÁ±nåŽ¶‹4Pvah›¶l×ywtç8bÛ^®RÓmˆ5ßêZ59Ö9_¶kËþTµÕu]€±?õQËýåêŽ}“Ëv¿lý¡wËûuŸsÓ ÛåÕ³N‡Ž;æù^Ø7É
§ß�J†wíØ³Þo*!F>�à¾·ñ`Íëí>7
ÃÑÒêe^·’¹Ñ§åe.8žûa�/·�éq8`Ýæyõ!&‘t cVs<>j»>¿rûSömÍwEëCpÚ1{{8>âòúñs=œÆ1ÊË<¯É’ •Eµ=¿ex~}ÎÆtêêŽµ¬*l¬­`ÝŠ�Â{Çºìkã!©Ø²/¹Ävhf”û¼lmSWêv+R—}ú
ÕW$;Æî–ç»¶�ú£'¯K…¡µX	Hû^›ÃáÁêöòÑÕ¤ÃqÐVî÷KãMc Díµ*�cóy¾\Ÿ‡æÐžæe÷Š¡bÌyÝòrBCRS‰€çZÕ]½çåŽm°.Ð9}®‚=†Ñ¬ä+¡¦A€Mÿ:ÜŠ™¼lô8va[—åšO:�‘Ûº×Ò…¼©Ó—�P½”–]Cäy[b“º¡ó¼o÷d]£(N¿A�ZŠúpl°ãRöÚt)fÓG­% I)Âç}AŠƒYöyËjBcâ4À)ª–%Æ8Øýv_ûa�ºVx²ƒM?€œ¨ž+j×wªûíºÔ¶éÚè–÷Ík°„`Óß�T½Èbl$Ÿ!XÎé·à„£Èƒúæ°Åy[ÖÎÐ€"§¿¡†²mUÍÐ…mÎ—¼15L"§A‚ªo Ç€X·²Ü‚ÁÀé UßœaH1lë>#ö!f"§rªª$ÄÐ³{	�fÁ!÷ÍÝâ!¥¼¬Ë¶´L §Ið‚’b“u…$šþ
äp2Jà�ú]Û}Ë-›�"Y½ YJMòš·¬šÈ©�C€šÝ8}w/×ýÞ¨÷N€‰œ8QQk•5-­î{ú�6ýxÍÑ�[½”;¨*�…É²ß½ªQ�S	€—âJCÛzÙo¯hB@ ”mÖ5ýÎ}[£%6
2xõ=†0ÔTs-{Sƒ1Räô'�«z))¥¡l™lSÛ4¶cßÖd]Ût@]kU£€hâô’\È¬¥M}ê–</3{'öcˆ ÃËîµéc;Ï×m+Bc&µìm8D×¶Ì¥"öÁä¸çÚXÓ·­,ç}/6Ä®%örßrŒŒ&JÐ.ž“!¯û¾2´	’Ó¿‡£Öâ!¥CŠeÍsIchªUrJpÀ½æÒ°?Ž¥®7ÝcL {–úäóýîèÛiÎsÎ€®Ï¶§Ð¥®ú¦{Ø›¶�à¾–Ì–¡•8½ƒA¥¨¦¦PË¶U­-Fx-YMÛ§VÛ²j�HI¡‚>=Â¡j^kÍ±	�[™ó[‚ê
Õh}›‚sÑ¶7iHã®Åol’E3§’ xÝ­°k{ ß0‡04} ò‚­¶±£{�ó‡ÈºïKuoÙÈ‚Àé‡�;(iwÅv°¸ûu›[¶¤¨éB.†RÌcúµ®5&C‚§ß�S�×†®ivß×ÄV!xpˆœ~$ÕlL©!6í5 Ê¢àôw‚„J1….Õ[.‘]×xÉ�b“N r8	íæj›Ð(×Ý<Z4\^œ1…èØ@‘!˜	àô� ‡„ê«¡ë;ƒ¯×u‹Mˆ±lJPug‚!£F; ÍuÖû!ªø S`’Ä8}	ÕLT-°ÖJ. “Áé†§ #]Õ%³ÈªæZâž,¶^Š¬áØY­e®9ÆÄ(TI lú ˆt: È³š6 [Ýö¡)©Ò@sœœ¡ZsP´Šv¯K„j-P­¡Y(ÁÐ©ékˆp—;Á¢—"T�tZÕ<v�lß¶ÍcŒt¨V‡ Að"³AjöMŒHVßÁ-!9Ý÷°Çb’»ÜÅ`ÑL•^UÕeF(›Wº	#RE	’à»íH¡µTË­Pá2�S‚”cEŠ�ð’Ý@º@pŠ� ©À;5›¯°àLÕª£"„â`ˆ=©Y×ÚÆ1ÅZ_÷Ö¢!Vx©9 	�è«öMl¢Šot”Á„5¹Ù`ÑÖºoÛØw(³ßSßŒ;×½”’ŒmÙD™ MWU´èÙ…Ô¶â–,…F0T¯¤.Ï(Mìšlw­iìÉó’CmRjs.#¢¢Ó —;@%§™‡ÊE¦ªŠ`ÑÀºsn5P&ƒà*V��à;÷ ‹nÕQ«„66Õ¶šÑ…¦�¡”5" È$€¦ŸÂ	©*7jÐh¯Td`*‰�*ž­K†-k—EF™ä	‚ AI3eì†ÐÅT}[ï›Ð4Y{³P¨
AàÔBp8A]9äc"UT’ÓŒ^Ta4›ÞA„ ÉU Ê-IÜ+Š‘†¬
4­…œ×j%4!ÐéA�’¦’Q¨¬¬¨bk±‘"…�<¸2`F¹§o � $Õ*¹˜˜L^W""Œ€»×bŒÑ(ä½©ƒ•:ç=ÆfˆI¾¹L�F@VŒÓ 'U^!y —bÕdM¥{ÙC‰°�B•v°:IƒD ¦R¥dÉYÝšŠ¶MJh=˜Š¢M_@p
&©ºƒ1(Jµ¯pÍ9�pÐIî^-LÊ5'0†ä©î,p2Ê¸äÔAMo!Q.ÈÍ$T:¡Æê(²ÊIÕZP)Žê.ÐŒ„$�D¬&�Ó¿A"`¢*TA ”	t/Xƒ†®"ÔJ‹HNÉ«çXAœ"d„B8húupÂÍ	/Êdè›;hMpz¶H£�”£š` !wt0Y¥šz¢‡J‘t¸» ¹“Ì@Ÿ"h4\€¼V/ i4J€Cnn“Ï�F
 =íI$*¡0E	€(ÂItÐ§tÐ!ŠD8áE8á„D8!€Ð	‰ð©�‰ :EQ@}ú5ˆÐ!ŠpB€tÐe"œÐAD ƒQ„¦"œ":áS„Ñ§Q 9Ü!7Y¤Y�{ñU0ŠÔÔ���¨)‚NQ š"XCNrefÁ¼ún^èæ0n()ÔDÀj[”v>®m	è‘Ì=‡ÙrpEåC…' OèÓ*à‚jmÆ§zý`÷/k�Ú
Ž‚*um+ø¼4ÆF6ý5*µ–»Ì÷miÁD“jÍTŠÇ¶”¥dLÓ•0÷%õ]JµÞ½ö)±ÆRjŽMÓZÙÖ*¨e@”¦‚j©±m�z_•=]“¬ÎyËGÅ@š¦ß�èòL„¦!rÎHÆ%Æžm.÷mÍDBõâ5¤&¡®uZDši:Bty-mró-'Ðƒ«ø®~Ûy~}-cç©L	tP¢ A¥¡o-û�¡Œ‰ÑMÓÏ!
µÎâ!=Á/ûMLA€¦A`ÕV=»zÛ¯kÈ©5ÔôDÕ²o1¾­õzÉk9¥fo¡é‡X¹†Ê±ï|¿j=5!”à>}AÈU±;�"žï÷{‰6Œ�ùíåÒ¤c¢÷é^³îÜ4ër½ç8Ž 5X±çÆ1ÍÛõ%ºúæ|ó‡×ùrNmÓ€æ¡Â—¼�ïÆvÿÕ‡ÇÇcS* é+ˆ‚öÊxlú-¿î¥í’UƒOGˆBq¤¾·¼—m·¥9yî.¯náðxà¢ûÂ!�ë~™KÍ±}ì�¸¼Ïåx:ÚN—¦ÿš"ò¾ö‡·'¼~z­ÝØµ¨€¦#zÝrÓº=¯ól¡c |ú#ˆö‚æÐiÞ/pCs~–—ç�KÆ8œ¿êòí—›š§�™š�eõrx÷üòñ¥íÛ&:¡éç�B÷=C)¯/—ÃØÅ¶šþ.Öº…0¶Iù:cdg…PrmNOm]ŸŸ3�uìŸ~¼}º÷ñi´à€¦Xë}oN‡ž××kcÍ�5º‹€Ï¥4oøúñå/×wçÑb4ýP× ÃÑ|¹¿,;ß<ÕýóûÕ÷s×HVK-ã›Æn×ÛœÞŽmµââô¸¹Ê®z~›°]ßìº>Tiú÷ €¾e6ç®××ÛÍû¦…CÓ÷  ÙWkß´ër›×&õ184}°;Òp°­\·=ìÞ?¾í/×çÞžl 4ý}¸¹×Û†ÃSSŸï¿ÂÖŽÐôºï56]j—mÙKÓD>ý’¡ÎÚš·çþþñãfoÆ±B.N_@´É»!bÝË%¥†V)Q¶×šûwÇêŸ/ÏÎC…\œ~RÈ¼—f<ô~}aëß`/ßÏÇ7CÕ¡é 7W®ýSÜÊõ3pC,€¦¢ œS:6qÝoÕ1 h!È6ÝâøfÄýòáÛ€SÇÍX�Ó¿	�^W†îØ£Þ4—º§öË§ç±% éÑ·Üto
?>ßSêœ’ÈâK‰O–×�kÀáPâN7N=QkVó4Øíó·+ŽOešF¢öíž†/àÏŸ?ùá|ˆY€¦Xë¼‡ãx(ó§ûüxìbî"´Ö9>œ�xýîùþf8GÐô%zV�Ý!(ßïû`=R¡¦Xý¶·Ý;Æõå~;„c1‡‹@]s=¼¹??ÇùP‚³§«æØôg•m¿°¶�Ôt€›«ì*OOí¾¼\­ë»^4ý m®áôeçëwÕÏoZÛÍ¥é7!€ž³³{öËõåºuC
™ðéˆbåæ}{€ï«§6†P©éß†@Ç�ã£ûréqì@Â§ÿ ™e<<h{yýŒÓ±§[¥¦]9;¶-®ÏÛ=Eøô'Qµ…Ø¶¡ìsµYvxh>½>ÏÇtda¥¦ÿR(uŸ¸^–Üô]ÛTBÓß†J]TOÇ¸^>|ìRÛViúR(uÛ1¾9âr^1tãÃ¡õëë‡��áð0–ùú«õñ0Úf•šþˆðº¹µ}ëXæuÝSzÓwŸ_ÿòS|{¶»¨i€(z]Ð¶××=öƒ¢¦¸ûÚÔù“ºá0T°/Ï_©ë·¿ºåþ8ÚN—¦¹döo›>½—=>µ DMï Ðµo[8œCùø|óelÚb…š~¢èeÛýé|ª÷û·®Ðôo�Ú_>¿º?§ñ©ÕËËGÔæ`™•š~QØå©P÷Û}�Âø0`¿}ú„~h‚|úo ŠÚ÷ÝÇ/NÚî¯ÙÚ¡I¨Ô4Bµ×‚î-uYn[Ó‡ÁEMß@µe4ÃC—ËuYš&60ú´C ûç7È×—Ïíñ4„@øôD±jÛãñóëåE©m£HŸ~Q¬u+ýñÖùõõò�zK•ôéß‚×JôÃ[}¾Íg;ÄFŸ~¥îJý¹–rÓœ+ÆÓ¯Ë§ëÇ±k[ÁèÓ7ÅZ·Úi­¯Ï·®èÓEm¥ }3ÏË«ÍïÚ6Ñ§o B^æÝç3Êúùn{ÇapÌóÇ&¦>4"}ú	z]Àãñ¶—ËMÇ¦ïDÑ§wá%¯C8=`_¯—FýX	óé�!Âë¶Çt>n/ûµëÛ`•Ó@„×µîÍÃãã:_.¡M}JnôéG¡‚{îÇ£¥ÛüŠb}cÐ¡²§Ã	ñzù\ÒqúÆêþ²®×îØ»©NÂôˆ¨{¥¥s|^öÓ}úë�v¬ÇpìMû•¡%m:AØ¸Ûátj·ëë–6ô•ÐôÛQJìŽê~YÍ�¡¡iúÇðº+¦®c^´¤”Šqúcˆ(¥ iÏÉë~Ý¶tŒf…Ó_Z´ƒiÝçÕ¼�Ñ§¢cWéÛ¾­y__Jêblúß!å�cì,•ºo¹A4'Áë&µñ´ nµB]`S§{¸�@Øn«êCšß}Öô$Ð}jº>¥}»¹å1… ›þ  ß°µñ`!äõŠ9¶ÝxFÚÖÝÁ�8ý½”
ô‡ÔäužŒkð©…ÀëšJÓ&z¹ßQpúmÈk)!¤”¬”ÝKdD$§ŸBäu‡iH½¶:¯»£=´±Yë}ÎJ�EO…œ:Ht/ÅcèÛ¸ûVrŒ)Dsù†½kÍ]KÎR­ñ é'ÜK­–šÞ¹×u†h2N?„äÙJàÁV-mé“8ý>$”�“RhsØëVi´&›¦ŸB¸Š€&�!î¹B)6ždÓ¿
Á)ÔºCM3ôØ—mÏôF©�ÓoÂIu‡R34Hë|»™ºCËRæÛ\›îÐ'p^°ÕÆ R«¬Imõ²º2ÛÓØ.ëº.±Ä˜h"8%HS„×ÍÍú>rÛü"ZFœþ5.B¥È8ôH¹ÌeHpz§ ¯u‹èzË-l"¢@pú{˜¢è¾‡j©ƒù®K¤�ÓŸaoç6x×©)yóª¶°¿?äéçp@Ž":»¦ËaÉZâÐŽ£r�WTEk4‚Ó9TkÝBc]\íÒ^ZoJ§ÿA(ðš–Aõ¾î1"M‘àô?¡´¥¦5ìºµ}éï–ÇÐ/yúÇªAðº#ØÐ|ÉKNÝØ{É—-ÇÖ‚™ r:bjD¬­õÆeÎ×b²@€tB¬¡
,Ì)¥ÌËVÛ®oë^®´Ü!18 ‚Ó Q�{)4ëZwß—¶FD™	œ¾€J"MµÔz¤œ×5§h‰æ¢ªî0kÙ¼ç­KgËºÍ¬iB,Aî¥¸…æ`U‹ßsé¬!‚@º¨é¯BD¥ùÎÜÚ�<äû%}ß—}{Ý.Ç÷õv·�ºÇ.-ó­®f	Éz-;¼k›®äy^=´J0£‚Äé×!QVX‚ƒpÔ=åû=o¦	°&ˆ ÜJ� RJê›cyÉUˆ!€4À H€ª<+¢éì{qöˆÁƒÓÜªè ©
¬Ô5ˆœ¢Ö5yÓ†�ó¼‚jÌ|Št@Ó¢P‚ç`©‰–ó:o�)ÕeYæ§ñPçù~Û³bŒ2s€‰ÓD	T–PcŒ�•:‡3‘¦ê[PlzXÝêžc´¤@€"¤é{ETÑ…‚b1õÁ•çÝj	æ@‘ÃbÛç¬¹ �7¢Ë N?ƒ(
8
Š©mPîK-m±²@.�Ó[85EPÈQ,1Ã¡ÈdAu¯¥±>6ð²‡=D§8ýWI¨tw³X3ª2Š9£@8YQ‹b›ç>WQ=Ú
UŠ SÓ÷!÷*‹¬YÉºaõÝé!ªr9ý¢DHª¨f!˜Pl‹2^EˆèŽ*0Ä‚]ÕB:îûžÍZ%„ ªQU1š!Ùž£{qFP"	î•RÅfNë:¸¯¹ÍƒA‡HpúŽ…LÈ Rbö©à"œ"§Ÿ@÷J³ ©ÒRˆÙ·cI1{–¹DJœþN¸èª)¥ÖcYJ!“m~ßrŒ!L�è„8� Q‚K…fÑDW‰¤ÅZj-¦)T¯ 5Œ•žÍ+,@î0‚ 5}ÑÍQEk€¸©*†¶1/^‹UQò¢8(eß=Ô(RŽ% f%óàN
‚C‚ �¤êÖØvußæš‡Ø´	%EFt¨øn` Á)P SÓïC"—Ü3¨ 22’^M^6ƒ)€43î9T"PK�»h¦)�Ó?’ÜÝ`	Pa­bAU	rD�Ó?�  ZUU�0éžeŽF�ÀŠƒ0ÊK	Õ  HS5ý.8Í­’2�`•{•@G‰ ¢ Ñ	AÈá€ 	À)ÂÄÄHªøÚÑŒqz‚D¢H'\š"‚C‚N$P2ÉA 	H*ti$ �€Á«TE„£BD@0¢Âá„¨Rþ0þg(AN4Eˆ ÂI·* )‚r
‚ 8 @€C”‰N�@ÁáR… €²JˆSœJ(¡"  ¡éúA@Ÿè }z‚ÑúôD8¡)‚ú” BS„Mè Oßƒ_¾zéæ¾»¼stÞí­yÉÇËã®÷q>žÿï¿v'$Šp>u`Õ]^(Xhƒ[å†
d ƒDhê Š@' AªÚCl:uµ–\™g£§?ƒ¤âÖÇ€º2'Â"H¡VYÛ4)o»yç!˜«Hfi r}Å¶0Æˆº­eÏ½µmKxY³ÃSìšŒ�{ ",øô‚ûÎ­‹Ý0T_æY!&¢izÑQsIèÆ1r¹Îs[‹MlæRU…„$ÔRY±„2ý&D¹¶´¦Ðwh–ußk�!‘nu ÊkÉ
M:VåûE©õ¦éX±jÓéô®\_?ü
¥í)h °Ö¼#�Ž}½¿¬¹�hìÐFÍ—ÛZCJ¤SÓïCî+SÛôvÉ÷µX³wªÓÏ!J¾y=ôm[®ó²„ƒµPÓB`áæ©×6#5�yš~¨õ¾©÷€ùùu3ƒ
š%ß¡®ë‘×í�š š¦Ÿ@½x9ôÇ÷%£í’b¡ 
YeìŽÂe½y3ÄÈB%¸/{µ/ŸÞÝ>ýåŸ/øªík—Ï÷û–ÔÂ
5�psÕ¥b|{j·ëûk~:õ¶Ðôà³rÿîˆûËÇàÐ‡%¸œæ¾Ö-<±Î¯Ÿë›ñÈÝÜEÀï«º/Þ.Þÿb=Šh  Ú¶Ç'äÏ¯SˆlŽ]-÷ûªÑ¢}úH_ÊÜ½;=íß½¿~:C�»8õ�Œ¥l%=ÂËË‡[÷øtÀ.@Ó7ÀšK}�ÛÇ×ÛcÛšþ¢X¹F;†8—e«MJ’iáæòyYÇ¯¿üòï�¯ºî0ô~y}ÿKÄqˆ‡ÐÖuÑ–Ð1jú{€ºN§˜—ËçÐÚØ¸Á§@SÄ¦çáþüñµœš£R4ýûŽn<Ž˜Ÿg}$Æë¾l™©% y÷îëÇ·õ»¿¼¿žÎ*¢‹ÓÐ¢|8>b¹|¼¡éS’p  ÚÖåxzlnë‡›?�'Y4ýœ¦}»æÓ×_6Ûw¿úôïœŸš®´
ÊÙ0 -¢¦ß‚ h›óððö¼<÷y=žÏªÐô?@ ´çz8ž¯Ï—†}j¬ÆéïÃ	ðþzç¿|úó_ ßûZTmú‡p«¬{ÎÝ»/ðòáÛ¥ÅÃà(tãô�r+øò×ž~9ÿòÏß¿}ó¦-¥:4ý¢˜±uÝê~¿µI¡P"ÝsNm?îåÿ/Nzu[×ó ß÷ó£øŠ9ç*ö>ç¸Ž-!ð‰c‰Ç(²H0:(Š”‰‘h€D—^ÚthÐ(¢]þMzð
Çœ³÷^k®Y|Åã}ŸçæºÖK3+Iæ#´æóãÞß¿Ýfç.ÂIôÝ‡ñóÇ¶¾\~=åSEXˆË¿„(µî§ñÎÛóÛp8Î—Ã•Zþ‚À»^ÊÃw~uùë¿þ	ç³5´ÌÐ’±©—ÃC½}ýâ§ÓQ) -ÿÄvgùðÝ)ÿôíÿ»ažf#B\~#VÃx˜´ß÷fµ ±ü·EÇŽ<'è¾íyÊNÉìõxš·Ëë�çc¶ìÔ2C z�ukï_±žÆÁ!m¿ëü‹‚ë�?]ç‡9×a(-ö½oÔ2!öÖT’%§–?‡dè÷h§§éíúüCš&  e† z¿öxz¬ëó·_íx<!™KËg€¶[ž>•õöíËõq8ÁáÒòßCKÆ¾¾oþö«¿ù†ÓqÆP“ÝÛ}5„¥zTl÷ÞU­vÓòŸBŒÖ÷ááü÷¯ß.çãiýðÆXþhÉØ×k?þb¿}ù›ÛöxÎŒFÄò¿@ }¿¨=}>._ÿÕ¯x†¡XFÛ/‘�™Ç)R»·¦<DQ,?ƒÀÀæ×üø³Ãñåù×ïüøx(�–	ðµcúô1.ï?mŠ‡QÖˆXþ†Vöñô0lýõ+i¨e.Ñ¶íeo^NÓÜïïëµãÀ©«_pÇ±ÀÄXþ`sßêÓ€íåå§íáÃ8ìtj™!Š»íVO£ío/ÝÒ`Yd,ÿDmxçSi_ï?‡|¸ïŒå{`ÓÝÓÃÇéúåëO—c>!»!–DDßÛPŽâºÝTm¤ÈXfŒ¸ÇÊóÏŽzÿöÚ¦|‚`,ÿ/†îÃù±Þ¶çëÛÌ99ËQtÝ¢¦ÛúöiÎù|8u½½þ„t†ÝÄX¾‡ˆÞ€4ç´o+:l Ë¢¨U�§�O{¼üøÎ�#2–ÿåë~�‡ŸÍùþí¯_n§CIÕÜýbk+¥žŽ;¶÷[hb,ÿ"Â×ˆüð1ùûû+îeœB`,»ê\¿ïWÖi€AËÑ¼Õrz`k/Xš’h±|±·­åOŸÒ�Ï½ß‡ñPŠûÝzIÉ‚ËÏ!¢7G>Õã×Ûm+vPiË Q;Â†¹¢·+ÚÑrv.gˆê-X¦”V¿­IC!lùÛ{Ü§áéXõüv½â<T˜bù"ÔÃ1Gôm»zãd‰ËïCD´Þûáxœ·~yÅÅY†\kÃºÃSNI\þÑwaœê°õ·;ÇZJ$.¿„ˆÞ·;Ž�Óùv{ÿq¯�§‰¦å7 of‹¾õw¥!%$.g{ìªçÃÐnë¥£ÌC!lù_!Hßú†ãÓ9­ßÞŸQÆcžÚò=$2Ð¢¥|&Äívéã1�âò$òv‹<}<—öÓ·—Žá±S,g(œµŒ½Ç{òT*òò„Î+R~äµ\¿ÙÅÆŠ	\Î�%�ÝãÚ™*«ŒË?„dÁ@Cà~ßZŒÉ\þ;îþ±<MÀí¹÷ò1óp_NÞ’Ê˜3Üoôl9—ß��¡-PËÓ)Ý.¯_òmœJ�õe„ @jNØC)û~yÛZ+“ùò»‚”šÚ óP·ûm½Û`C¶ ¨Øc/ã|ûz{½öT†lH;vaÇ}_£µÐ"6˜ªåHZ&H |W¯eÑÛõÚz¶ãqÊ¶_[÷2¦lž´|† EïÊÃÀŒ}]7Ÿ²eq9AïN›J¶æW�¤”‚”Ô}«û½_·8p4%-	@ã–1žÀz½­N«0Ø2"‰=šã‡:àõzMÈC-¤¸ü[‚�&êaß¶ÛÛ(SJâ2C²@—hÓ˜°í·­GÍÙ`Ë?ƒ )úåqÎ¹Ý=JI)[¤X~
,Y›‘ã9Û~¿ÝV©(±K¹ÆæívÛ8åj‘E„ï@%Ç¾]€ÊA)ŒË <º4¦š½ûž”RŠ¤å;[DŽuÕµ5OÆ�F„ïìÃX‹G»£�ÙJRŠå3ëB”z`Ûº_#¦<Öìp8,%—ßE :<R™d¾¯÷šR²äò
ÁŽ@š¦ñëúûÁröì\&H`DCXKR\²%‘Ëß…àF b‡ÙT³÷ÍïŽ”,Á .
IŒäÔÎ=—ñ`Þ®W8rZþ$ ttÁê0ý[YP|Éò¾VÕÃ)åýí¶ÓKµìÁåKEµˆëCZc½^›1§D —#$ÐM„·è“�ë¸í÷÷[Aæ9[ßîž9zñRäòr_K·Ã”ê}¿Þ¶Z‡¡Rá{ÀAf ¨Çfªù ô›n>`JEÖ[¸`…•0÷.XdÁ¸üsøî >ÜÇçò~‡jEmÃÕ3*jR�èL0[þA¹‡[Î™èá¨AË@j9Tj±À=íUL–$DC£�Çdý~ß÷˜PÅ’Ë?„»ß§ZÆ‚î—Èu?½ý¬sù·!)àZs/Ói,÷öv¿î(s<´y ÙIpùÏ¡`Ý½U›k
_û+Æ<	öÍ¯Å¦:¡xì-LL„Î�ÙÆQhk÷ SAB 	Ð!�k¿ßï[X�Óòs"Ã"•Aµ·­Û�³l“g ï!3LËŸAp£ÜïÕóT�×X·ÛŽdÕDFh9C‚ÂÃê@km[GŸ,›“„–¿!d¡¾m†a÷u[•‡œ»¼3�dˆË„€DÇÔTgúv}õ\JM¤¢…©Î°­¯{IHI ’Ë Q”€Pl¹œO³{Û¶­¥‘H8pù!)(°ÉÆã0¶ýåu}ŸÆ‡yŠ¾zä”‡É¤æ»è‰99¹üGJŠfmä”“ö«§š'gk]BMCÎh½Y¤HA�Ë_ ¡ðÝA«�%a{¿Ý‡RI#³Ñ)j¢§™¥ù=.	)e”¹üKÚÑ,Ï6lZ×†üPÇ¼a8°¢zÈ�—#B!’®-£Œ%Yk{c¦Lº`%å°.x‚±‹-e$cPË�@,ÖÙU¦9kï×Kjkd @A�Éá{¤8ØÐÛ~]wËÈ9È ,–?…½0ðžR©DÛwæb)
Á@.¿	.—˜ÔÐé M"àò?# hÅÃ9ä¢¾2)Õ¨rD¸…H-ÿ€) ¢¡Ñæ)k]ûŠšfÆÞ¶è#²�”(H�{G±Œð{VÊelU¾…yrƒ‰¸ü'Žž"Ìr6“íÜ\a†œÂà� —?‡ `$§äá�’­ÐÛî@çÁ÷û¶Æ4Ô¹Dk·ÞrK25l*nVKÉŠëv#ÓiHˆ~]·=…%dH�9—	B0R �ï9¬rl¶ËP˜(�0¦9'¢IJAÄ ‘ËA!wÏêáÛ
êP‡;;‘
«!ºK9™	
GX-'H`/^•QZGO¹¤`w)™€–* QFÒ½Â²$46°¤™¡ö7+óTR�KÃ–I"€°0’ÞEa0³®Ýa)Rb
öäZP‚ ™Èå¿B"hˆîÞ9—Å{‰>”™ ß�¤j		�ÔÕR*¹Jw¢æ\”[CX f B³™¨=m©Wå„Úå�!‹äL0!„àò{$†‰�GÍŠÌz’Œ%H…Ô=œ�–Ì@ `&ë`È$BËGHÔ’ar¸€dA%g'"ï¶[0‹ÜØ“‚ !dX7%�Hä]€¥DÁå dÝ ¸d`,&H!„@äHDôØr$UæðŽ�É!("Àd4ºË�†hÖEXŠp´ä€—ß„ ’àŒ ˜•B4+0JÑ	AR fÆ$*äD˜
" aÉ’ AË¿AaN
ŒËçÿ{n‚ -b!‚’	”È DQ($1DA d¤C@@AQ`�b$‡ @¢„(H„ 1@,…â’08!FYBš©CA$·°ŽP8KFá]ÞAXff=Â"h¸dPAD B"ÉŠ’�°T•É{„ #A@„D µdˆ¢ PbP!¹Å-ØÓÆFfp™ 
0Ad€

�	´”™eêÑACrq™!…÷–Ó0ŒÝû¶íe)-‚zç–Ê0#bm÷¨5O…ÒÞ´!XHF=O™ØöÛîÈ…ÆÜM=ö„q½{‚±¤"œybQ¿ÅæÕP{Šåÿ€Þþë>¥Óôñ[¼^üzÂéËç—å�!À£9M¥ÞýU{ŠÃ|ù=tï{ÍóÌ÷öörèC®PË_B”;‡©xßšGŸÒ\}Ûï{CÉJN-ßC¼Au8§Ø×Û:Ö’HBÑ×Ìñtöõ¶n{N©Â å— ï;ÆñiÊÛû—÷‹ç4�¹¾no—VË�Bh1NçT^¯¯ä4$ Ôò=D!v)OÇŠí~k1V¨å!®§àáaJ¿~]{ÿ…µÓÝ—¿QðÞYÇÛåm7N…-ÿ#D\¦¿ÉOß=¥_Ýþèãç/�« ˆmøqNõw½>ÿtÃÃwÓ:AË	Ý7+Ç2öõî-M(.jù 7¥ü‰ýýz7œ¦bcß1�Ïô÷¯Ïãxž€‚Øw–§Ãd_o_FêÀ€–?‡Àˆ•ý4€ëu»+‡ã8¿Ü.÷Sª¡å €Þ¶ûáüýè×ŸÞã<d›¾{ô÷·gg=�Ž a9C ½ím>Ÿˆ·—K	ƒ–_@ÄZ.ïÇ_”{ú?×{ãËãªå—€¸{*?êòþò›¥z|ª¾ýô¬ÂÂùóÁï?þÐâ”9~‡íþå­�µLŽeÿòöŒã8Á: å÷ °sg-ƒb_·û0Ëª·Ëªy2´  Þ6”ó±¿ïïûé8Ô†Xþ‚÷¸x<Æë·/=?>Žbg—¿ÉÐz«§�X¯ßX5Ú<øå—<%"nž�>÷Ë·×5m‰‡ã¹¾¾}yÖ=—ãùœ®Ï·éC=œ>îx~ù!O�„—O�¾®–?=áíòƒ·9Ù|®äíù5ãi7 ZDmÛÝ>ŸòíýË¯ütÙ… cÝ·úÝ‘—Ÿ~ü›k™ÊôXsûáåe›ËXóà×o/:?œÁ‰bk>OŸæx}ýöõq<Š´|A@[¥Ïg\¾üúŽãÃ¸Áœš{?Ë·ë¹ó¥Zþ=ÎÛ5øôo·¿±ôtÚ¾QË@2ô»¶áóÇæ_~úU>G	!.ÿ"vm÷Ç§‡týú¼Ûááþé™Z~	huú ]_·ýaj
hù‚ˆ{løøqzÿòÖÆ¶Zf€¶í^NOc´¯?ðÀÙNÇ³ï/ïH‡ƒ² -¿ðmÇáq/—çãó4J‚Dhõ½>~¦¿¾þ¤ãpt(Äå;H¿ÅZ¾Ÿýöòƒâûy„´ÛÛúñé³§ÿëÛž÷OÏèm_Oçs¹¬Ïßš—s3„Þ¼žžžÖýõ0=˜3B\~Z2îôãÃmoÏ7‹óX€–ß‡ k~íöð=øÃ¯¿Æ0õaHq{]w†�-'ìÜ™(}_ï©Îó©¿¼¹dæa:Zy»¿bÓ�?ÎÃzùö­Ë	aá´ð;øp:÷Ëå5¾�¢>«Ý^¿x~œ¦Ž ¶uŸNóz{}AŸÊ¸æ™°w·ã\öõåž‡a2´ü=Œ¾‘ã¹ñ}{ó:W‹„€mÛÓÃ÷Ï?Ýp||hZþàûMÇ§1]_¿¼âQy>?PÏ¯¯9b®çiÞ¿}û±O8Œ‡O©}}ÿ’ê�`HË¿	QŒ¦vœçú¶^ßo©äñ<c¿]_™‡š#!dˆÞÌÇ:¶½7€ªçGÄåëºû4>:¯/W³:NÇG¶ýëû{�ê  –ßƒ hÝ£~¨¾}}ÞGóñ\ðzý)¥q¨¢SËw…m˜NáqÝ yÈ$bù­iŸµm_oC:™ ÄØ÷>œÏƒßž¿èa<)û’ý¶sútè··ÛÛù4•†Xþ£õÇÇÜ×÷7Y™€X ßZ�?Ø¿>w+ç©‹pšÇeíçï†êÏ_¢>N©œìíùm8=Ín�™Ðày®5ürÛ�AÇ¹¬ëûk¯u(„  ­Ezšoýå‹ì`õáûŒŸuoi:~7”ë�?¼yùPœhùhÉh­óðÝãvýúñÝ8+’ Äx8|f»¼ÝF<²€–ï 0´AÇãÑ/÷÷5Æ¡–Hˆåï@`´{:ëöþUçñ8y$Är€ÀÀ¾wNß�þòöÃ:­Ãøp>èíú¼N6�#7Frø­óñtŽõýr†yQ"£ß½ž>x¹~ÅvÈåéé˜ß®?^óé<È ¡5ŽO�ëvùQ~Ç�ŸNl?>_òqœÏoo?nã8L	±ü.D1öîéü0ÚåÛõRË8œòååv™¦1g9µü—E�­×óÓi½¼¾Ù5ÕétJ¸>?Cƒ¥ã9s½~ë8Ù0ŸÏ¸½>ßÒãqR‚¨åß€(Foœço÷ë×ãùPýúö:0Of¾d4­åð±¤õþåjû<†Dùvx˜Æ¾¿|û6NvÎhoï_3Îs&ÅX&íwç�†ço_ûažJJ€ZoÓð©Äv»^ëaªÉ @TÛYæŒûí²¥‚t<–î×÷ûût“‰±ü1D„¯ôé8¶v¿­y<¦ŒN-¿„ˆð{öãCQ¿ÞßŽœrJ})ˆ¾ãQ­_ï[dŽÇÙoo··ýT¦ñ|žo÷—7¼Ou<l¿¿¼ÀOsÊ ÝcµãgèíÛ·ëPK==œûõíöu˜NƒSŒå;ˆˆÞvËÇIíº½!M9ÃËß‚ˆPë*Ócåzÿ’Â0�‡¸ÞÞcÆÙ! bìMvš¦ôåýåíà{*ãÞÞ~$&¢–¿QÞ”K�wíë¶¹Ù)o×ëµ¥±$bù"B­Y>A·Ûs;c(æd,ßCcã–Gîñúj‘óÔR0–"Â÷�ép ®ë×¹†Lóå k_q>�ùþrùA÷’‡#ìíå­Ì§qò0 ÂÞ��O§¸Þž÷u|H5h± ¢©c:e¿½ûûXkQR,Gˆ¿ƒ‡ÓÑ^^4µ&cù+ˆˆ~W?|ëåööŒñ<—)ÄÎë:ÌŸˆç·W|< :µüDxëÄt*~]·÷œf(–w(Í§íòþ“Ÿ†C$X,½É§ÃÑZ»D§UËß‡Ô˜JN}m¶F�Ç»ßn«4�ªmùW¡î;êÃÃ¹¿¼Ýc˜N5%X,„�÷RS¶Ýo)ù\Êºí«ùÈ‰Ë?F4µ©jÝü¥cM"Áð~÷üáÓ1__~êøPŸ^Úò¯A±íL§óY×Ûë·—§)Ë	ò½WFÔËmoÆRÀå‚ Tô}Ïõ<ª·÷×{Šc-(º‡åZa­›%f¤ Ð±Å\O¹¾ïïïÀq4ƒb–‰"ÔÕlœN9÷ûå"æš—¿‚ÄˆÝö¡Lè«<×’H.3	ÑÖ‰v�×¾NÌ9’ˆh¦”“ï½¸-9¥¡:ƒ¯íý"•4×þŽÈ)»ßDsFëwïCšÚèË÷»?ö˜àïñ­NûÇ÷‡Îå�àlÉQ9FÞÜ÷Ví0–Œv»ì[*óaª½ÝûŽŒbDêÆå{È}OLG/·ÞÐNù˜ó×ÛZò˜ŒP4ë(¹ ß±nmÐ<$qï{$XE–-ÿ@¾;-�æ—ûEæñ08ú¾îÝr²Ì —
*¼1Y~ÛÞÛq<œ»½¯ýf‘SÒòð}¯ûtx¨{ùq÷õ�¦íÁµü!ºxŸÆ9¯ñ~uÚ&çò;$

¿ÏÓÙ[_ßÖý€y{´}½#j²"Øò‰(ïkV=5â¶Þ²�‡Ã<oØVµ­°’àòÛ�(�pß{¶ùdvé/ï±Mó0
[Ûcí…9¡trùáÑ·uÌlízÛÝX²"5ãòÛP@
ï=•:Œ-Úª�¬õ`�½ß‹Í(&á=q0õ9È[NÝ<±dC¬PlšÀ¶¯íã4²Ú¾;G&s€ËŸ@b´ql>æˆ{cpšks\us8x’QäòAÏÝ˜J&lƒ{N3§æ›_9äiLÜýÚ�ˆ¢¶ü&‚d=õ.§�ãxÅz[¥œ
a`xsöiåûm[C9g $¸|‡pídšê¼¦-m{¦ëÙ%(º‚¹2)îæÊv(Ù¢ïÛÚËXµ÷­e””’…‘Ë¿	‚z´Ä¡†o]*–™vÛ•íÌ!´_ï³�QœRì2+cüõÞÌS.	ýÚ#P
R€ËßÇßk˜&h»äË§ŽZŸ?^—?„ 	”@ùf­LÃ¶µ.Žf	0—ÿ#<9%C�fVj©)õíÈã0$�Ö½—”Ìd�{cä)WÇåroeœ§õëÖ™™A�ËoA„ˆ=G.5³í-Ü"!% \þ.$ ÔÙ­ÔIŒÕ÷0¥$˜à�-×±Lðëk¿�u<ŒáÞúŽ4•½©¦¨�¸üS,E-3§dŠÕ ˜Yâò—Pxã�[‡�6†¯ÛÖ‡:&Æ¾m{Ï%¡vƒb�°:”n÷ÛºrÈÅ"C‚ËAE�©¯�\ëœ·Ö#1™™ ûé>½<~}Ø¦'?ìïé§‘sµq<?º.�Â{ó¢ñ8”ý~{I‡2œ§Ð~½ÃÊ±Leë+MÌ¨0@�™ hpÀJ‘òp˜RÜ×Ž1…Ñ•XÑä–À"Ò2!(sÒÚ¹ç<�D¼Ç–ëTŠuÑiu ±w$ÂJ—ß†@‰A-ÿ>$@R£8¤äºÃj-Õú
$³l€z†RË$�¡Ý½ÔÃ¸§vyß”#e‘&
Z~"�Ôµy¡~o®äEIŠZ~B„¼õ‚áXï«ßIæ‚0’K†–ß€–:{’ÙÐ‡4Û÷ûæ+,�‘…è�(õ@ù=n*–ŒHA$.¿D DŒÆÐR‚Ã:ÃE+I©¡ËÂÂD"
Ë,]M¡,3™	žºqù9$€&ª7ö”'ÍÞÛ¾VLÕA¸šRªµ°·½¡””“(DãžíPJîûºµT,%ÐDœêÙÊ€Üvj$%ÞrSUlÞ0”T€¡ÄŒää2@‚3 Ê7!Oeìk{ÝnJs=Ý¡;¶HÆJ& Ë_@ÞÑG³á�°!›”½ˆÆå÷!�.¤œ°aMIÉ,]�¬¢¶«µdZï=¹ÃòÌi×ÞbÏf,b0Ì‚LÑ\)Í%%\ué##³‹f…¯YµŒèzO{Ð˜““àòKH®VQŠçÖlÏ	YŽ�‚™qùMˆ"B
ÑK©m«µ9™À„K–L»Á+‘Â×ìLµ@½•^`™ˆBãÖ:×Ðí¾ªç:[Bß<©$“h!o•¡ÚÖ¦4äìØåÊÌ‘´ü	¢˜Œp¸� ‚!DK…Á6c1”†ÆÀŒË?@ 0€á-¹GhHa½38¢¸·žU˜RB†Zxõš*#V$Y2Nàò»
AÝÅ4dZ‡–”!tï°œ¦
k«¯kžÜVuÕ^ÈB€ 0ÈåŸ#T’å�–•‚”‡ƒ"—A®�eZôä’Gm-¹a�"h¢È WwY®…±·ØN³I¸ÅÍ|¤
ˆ4
@ËD�®@RB’£ÇžEã’�Ë‰n„Ñ ¹w³”t´´P
I h" #$).‘„cGÈ†”Íš7'e•F5ts3fs¸wóH¨FaçN$ºG#Ì¬8ä! Ôr‚9h)‘X2¥èêP€$¸|A ( åD8(ˆ�Bf¨=Ëµ3ºÑ²ŒB�AËdN1„€HŠF(àŠ�‰ D‘”Â¢Lˆpf„B€–b—�H‰’.É,QTeŽ%d¡ä €SjD@â2B� �àòsaƒ 90#‰÷ -aªž]�;Æ,*Â,¡ì¶¡›&P°ÿçHØBASE      Up  xÁA  ƒ°YãúÀ þµ,9V¦QU+dä ×(ZÕ1ÙÔÆ\ŽåP¨I4pE“Øl²5qº¹a&)Ñrå¶š 2 À±ÉšæÆªXLY¸U°rQ-\`³áb bnÐX¬&ká2"`W³jEœd*«¤¬¬€Ô-"ˆEY«¶©[®ÖjÕ�Ú†êV%HÑjD+$«¨Aj%hMrµ -•‹`mB
X LÀÅ´dà’€ À2&‚ €�$£Ì)èÀ&V›e&¸‚ÚlÌÄ®Ä•Ò�²Yms«a,f%C‰(�°"€8+
!˜€:@+Ú¬ÙFedŽl°1ÔÚ¶¦Ò€åp-Ýfº´–dŒrR@Q[#a°tY,`1PÕHÜ¨ÆT`nè¦µAŠ&E©èÚt*�cÅöù*?BPOS      `v  xÁÁu E D±…ƒíéÒïñúAB\H‹Ð‘þýïŸ?~ýúõgï÷×ßýì|¿ï½ïçÎçoïÞw_ëÝRžÓNËq×	çéž¼é<¥{¶ît÷è:Î=»-çÖ±r5’´p”zn=Îu-Ž.gÃ´M‘à,Ñ³&i––jF[4Z“9"'HÃ„m�0Æ�¡28#a˜54ƒBh18L+„1#,X0Ù4ˆÐÐL‘,a2&H0 X Âh`’fÀ `Y,0¡Å #Äh!`!h`"!C¸­€à"­–…À´ZÖ<Ž†¶9ËÖ±3fÖxÌ2:>Ž˜µõy?^{ï‚L×Ðæûœº—sòùÚ´u¿®YçºßF‡çéþtî ÷´œ²ÒÙûÅt-Ù¥}?÷÷×k÷ü>û™øüùý~v?ß\Õ“%Þ¯»÷¼>þ÷¶6QCNF4      Ë¦  xÁ]ŽA€Ñ¯ºú6MÑ€Ã`&	fâƒ‰³	7pßuQ®ÉeøbâO&!3AšÛUå9îëèGG™}rLúøjìû×¹Yß/_Ÿ^V�áð�ÓäÛ;lËRös6­Vô[hµÄ¶ËmS¹?KvGŠÛQza±[—j‹]kÂ†VG˜è„èLlÍQKZ­Ù´z�‰Ölh7­Î‰x½#z­1Ñ)&:ÃDÇ˜è[¢¢×÷˜è'Lô&ºäÇÚ›hƒ‰Î0Ñ€Yˆ	ÀL4½.1C,D¯�NDo1Á0ž»;ÀLÄ1éDèD C°ßkéãvi"Ø‡¢·`DKŒnŽ‰–\ÿ.WÏ³Ì‰ÝêÙÞbsC¬›Ÿ¯[`(YwAK9ßtrc=Ý{ZtÍ°¸ÜÿL@:°o˜Bÿkzç©‡ó�Ð�¦XÿœJÆ‰8\«!CU�ªwäÀ0Ò’#ÍÅ¾Çì¦—šK‘ÌAe.úÐ¯àº?@!¤²/SJ¾æ0åPà²¯I–“â4>Œ®@•ˆð©ÄšáìšH7�gÀ»<L,†.ŽGy���
ÍhF3šÑŒf4£ÍhF3šÑŒ~æ?ô»ö/TEXT       Óø   xÁMnƒ0Ðï(s bÍŒ› ±0àÐˆŸ  ‘ºBJ•EUPTõü}cÐÇ1Ác¹´#b©ì|V—bó�µ¥ø<ÏÖRNšc™b9šàM\Îï'©£å±“ø‚óB„”Uè÷Eç÷“ÔÑòØIB¡Zh eÌŸce>©3â9¡)«ðI�‘ ªÍWšÐU›–·é:…­jÖ?k~^w±þÀº\Æ¶KQëŽÃµéaƒeTuìÑUæþ½ã–f�3Œ[š]Ebø/"6-CLIP       	           F*     F!®ZTR

SMP4      @Ä”i  xÁK¬®izäûyÞÓwøk­]»vU·ìr»í˜ŽÛq2IÚNŽI�€Q�‚l< „`Æ€Ad1@B�D0x‘3gÆ1@Š"a‚„Hì®ª]{þÃwxÏÍuÉ?üÇ@þ]�”ýäÆ)üp8œçù|8ïËï=}ösßÿðÕ¿ôÕ÷~åGïðýø•?Äð+xðÛyÀŸwÙãó_Ä_Í?Åü¯ ~?Ë?ÈüOð¿àÿý§ÿô»?ùãñ³þ³o¾þôéëo.ß,o×ï.oË§ëëºÝ×­÷b�¢ø üÃßæþkÿþêô›Ð#M ’9BAB`J
©…))( E1@Œ
„ !
šdŠ@ P* €@ Â�¤	@ˆ‰ b¢”œ ˆå Š€UL B b�®¤�„�BÔe¯bb°ªÝ(u"Pˆ ! ¢Ì¨2{P„ @„
Ì`Q§ªÂf­÷&…
¥ƒ¨A‚¨I/Ú[Ä©‡:�™5tB„Š  f
Dös/±·°�Sw‚Õ­ÑOq¬[¼õRúÁ¯ï^%ÿ$:Fj15UqÊ<‚0+®ºpP-Xa¢p>Ð1ÿ„µ¾ÆÁÃîÜaI‚�ˆõjeˆƒj«ËZ5©‹Ž
ë›4L> •}­N$)Ô1ÿ„uk�§µâE=„yÁÞw…c×Ò¶U‚óâÄiþ7@˜õ	A…E¦ªÞ1ÿ(»¿Xú°ìo_£|Ï=^¦=ÿ(æöyv³Þ—·ÁáóiÜLÓÉÛ}]_ƒøé}¿ï7õs¢@ó/‚XÝuˆ³ýv½×�„"  4[ÊÔK€Hž@{5†±–Mà‡Á§Uîmí`8æ_°¶t™Ï!mÏ¯KÃ²—ü Ê.Cz˜p¿~Šv©©‚è»vwrio—*.D§ù¯€ úÖtœN‡ò²|Âäç`þ	Hïåg§ÏðvývÃtÙHÉ¿
ÄlÃaÂR.w„1Rºä?h»0½sþºÞ7‡à‹Šå  VZÁt>¯Ûå›®çq(ªB–Ž8>œÒ§ë§i¦ßE,ÿ:±Ú,NGèµîÀ03U¡š¢­ÖÓ»‡ñò|ý.FŒó©Þ_Ÿ1g8™ÿ ÷îtÚÛ§o0}vøüáq[__1OÓÐ 2 Aím“áü0ãå›Äáàª¨X«ÅÅš­·:Ï½l÷ë¡Íažc+÷R-ÆpðCëo·­3’÷¶nÏ•“<éÏ÷õ2:?§CYo/…ñàÌ3©²öéñÉøéöŠQžîãnùK�*m»òôá=Ê7/ßàø4Å* óï�a[(ÓAÛZ®ÍM.TË„ôÚ�zyiUŽÓC@)Ô9B•’	¦`[ÑŽCÙïßá8MÒAP¬¯>=ÅøÚ>®KHî<È^–·ŠÃ´ƒùK ·"ÓyF¹Ýú8'Á<‚Ù£öêÓ‡öòÍÕ§Ù�QòO`
³q~ÿ¨·�¯˜®C�’¤·kwó“¸ååµÎ˜ã¡/v[·�¢o^,ÿ&Lav£Ÿß=YyyY0cuÌÀvÝãé‹IŸ_?ÝOÓ„Î(ù×`
¶Ý4}vï×ç>¸ã12]Ëý†pÑÚr»XIá¸]^“œƒ‚ù×Aˆµb!Í{oö(ƒ£HþÀ­ <<×Ë«ù1F81*‹6=Ò­µÔ.ªïfÖëú\¦t¬¡`
[îëüø}lßüÉ2|6œº4…•}ñŸ>»OŸ~ÌçT!ÒEó¿BÌ6ª;ûZê"Ôa:H¹¿] SRz±<ƒ³8†Z—û¦º‡å¤Šmk;<|6ÙË×ßmï��[×æ_‡)ØÊ‡/ßaÿøºèÓ»IK ™¤ërëõá³3ðñþ–†;Ì?!f«×xp¬ë^œ‰A@éèn8ÏévÙoÎÉW(†ð ë×}…:wÒ—õyBL#Úzßú’ïN,
Pq<`/Ká¨Q¥Kþû  ö›Ùãã“”·�oSxô€%`)æŽOÉ>½|ª.žÒì†º_¯u–ÉQÅò UÚ²ùñ‹£õï^ÞÆyœLÌ?°ì{|ø0âíãŽç)hQ0ÿPmÆé�ýùzC8Î‡CÛÞ^.Ã6%¡Röm;ø9,ß~\ñþ”Z1ó¿BzÛàƒÙr¿÷‡áè÷·ûp8t8±ü¤×EÜé4†ïÞ®8z`»õ}ˆã1ÊRïÅ¹@Jþ]0{ìuñŸ?Lx~ù“§Y›´Ýüøà}¿ÝWN.ùª J¯»OóäX.K…Äiô®/ÏÓ8<@ª¬ò6�?œpùômÎÃÃ4�x¹½iÓø8ËííÞÇáÀ®  /¥N)–Ëúô}óbypÙš{8ÎËëÇ¯Ëgñì­Ìÿ%(–ÜáhrÙŠKQ¡Ùƒ¥sHïOãívU„Q�"]i{‡›§ºlË¾G†q:â¾¼-æ?†ˆK½Ñ;Pò(b¶Qü­­ëç"M( ËÝ¶Ç/þÛ?ýÓûœß�jU�ùÇ @š®~:é¾¼-ý 3›Ëÿ ßQæÓ¼|zAˆ‡ÃYpY§“‘

ÚråéÃcÀåg×Kx<G)^, @Xj÷Óã÷×O[œ‡±ºFæŸ€"½ïé¨{[®‡‘P€‚º•þ0½³ûëö*c@/–¤•]§ÇÁ¯·O¸)�iÐÍÞ–ÅÉHb}-pŸ=Œ÷·o¿Æñ=ír¿¹! „ä„˜mµÄãqyµ2§yÔº­ë™\ b;›>ÌO×çË·8�“cubù/‚Ã†îæ‡ä/o¥?“¹FæÏA³�N�µ¿õÝBš®n·õ†9x‚’  •éìu½o(Ðx„«í¾Ð‡ó¬}}{©˜Ç JÉ¿BØê¢ã|<·ë§™ßavëõ¾”˜R€s–
BŒëZÜáýc)ßýsÈû³Gq*–ÿ,aoðøþKi¯¯ËQç1¹€Z¶"p“ƒË3(ÒûÖ]8[)õ­"ºQTÄòW @Ðîéó'Åíë×}JçpðqÛ¯÷-NÁ‹Šå¿Òvôtx7éóýÙ¦á8‘]…Vè9'¶eÙS<|Ü®ë:èìŽó Ë²lÍT´<�¶²×x~|Âòéu‰Ói‚$Ï @PËçÇäíú	:¤³yÜësiÄpŒÉïûÛ¶…)* ¢‚)�Æ¾”pc8;¬¯÷eˆCT Ðvât<«¿~º­.NÚ´°ºë0ž’^®o»Ì1)�dq5&'¥ï»Bå�Õí¶Ð�zˆRKÛ¯Õõ4§Éá²ß‹úSœ}»n+¦˜ÄuÉ¿
õ^Ûðþ}l?}tãÃt}¹î7Q�Xþ 
ÄJ/ãñ<­ûòrI.�‡Cªåõ~ýáaNÜËõºa
QéòP„½î>Íì¾.÷âqãµÔô4ŽVx/{mq<NúòR6èøà"öõúb2ŽÝ‰P´·m©òYš—û§ë›¹‡Óðˆ¶ß^vÆSt
ŠX¿÷>;¥>»ïN!Tì·eíiœ‘­/[1Œó!¡¶×ûŠ)5P,O ˆÕÝ$¼›üº_Ÿ¡§á”¦P°]KÃ˜>V½ôÕ‡a�æ5ŠÔfešçQ–íõF7‰Š8Ë´BÕÙ{Ü·åÖBÞz¹¯êç JÀÒ[õïÎ§z½~ºÇt<žÇÁ­÷mm˜>ô{_ßZ‘i:Œ¾_®×Å¹¨êZþÈ¢u^dÛ¶›ƒOC@_ö¤žŠ°õmçiªeÛK8F`}ŠG©v_–ÖôçàÛºÞv§Ó˜¢mu³=ÄèÄT:ªÔ'_÷¾¯w	épŒµßÞÚî§4ŒÊÒ7»[‡äzÙö[£úóÐÑÚ¥MãÉ9×êk-¢at«û¾×žÂi0)k¹T¸i�`Û²ï]tT×ó�@a_cÓÜ°Ö�.„‰A-O @PX8Î�år½u?ŽÓ�l·²9ç}sby!ÆÒkLgŸxyY®CsrZ¶ý†št UéšÝ±�‡óI¯—K‡ŽÃ·ýV¯Ãì"&Vê2§ÏpyýTæpšÏv»_˜Ò¬…vlkÀé1J¹}kKš¦Qö�6£"Ô½ÕZçqÔtuKÙÆƒøÒ÷µÞ|˜�}¨VöjeL£‡®÷v•¢‰å/@+Ö]:ˆ½õ—ºw¸s˜´ÖeéN’:G }ïËÏCùôúÒ¦ãùqœî÷ÕÔ�“8 —7ºß¯oWÃð#ô¾/­E?¤²o½9Aôðš�`/Ý»4î×·.¢“Ä"ùKÐjaˆ“ç½ÞêŽä%VÕü7Aô�æâÌP.å¥0ŽOâ‡Z^·8FÂ©ä/`­W:‡nµÝ¸Ã0úz+%¸‘’­íìa8Áéå²í^’ÿhV|uq¤omÛ*¢ÎÎ³ö»9K^$O Ø­îzN~_÷ËVàýÁ�×R(’Ô¼å¯@Xï›”q8€{½,äìfQö¾¢FÑ¨Îå¿³ÖkpÑ…n{“Ôœ:ïò/�´V¤�Ãœº-¶­ÎKTqÉ?’½o=x.ë¾*dR¥Jþ	HôÚ8„côõ¶›Ý êÉ?…±hwLjuß+Ú(É *�œ`Bë½Éˆä€­iªÎ&Ö‹yyÔƒÞo×»iôÞBW�äöÖš„q0–½¡{xÕüHë­B¥¬Û>2„à´ss†¤*›Â9xõ*y‚�½ÛæêàŽZJ]ntê¼8ˆäØ[…¹èµ÷¶@¼Hþë Y¹;	'ï¬¬æ’K°õÎà5‚uï’©æ#Ø{éCÆ{¿ïM\Œ±zƒÙî÷)Ì©•r-K‰N�Öª¸Á;k½¼Óà»“üÀh­ª¹è¢Z­l|è¬ß±{ïÒh~¯µ9œwNòç i•E4¤nYëqá nG1x¥sÑD;ªl@:†Øn·µõž’WñéEZˆcˆeÛêÚmrg'\ûMž	J+­ÓyŸ\g­”Hê0ô]”ã1Äº/KeJa0—ÿL	Âh­À»4GÛíÖ¬‹ªJ Œj,?„TYŠ-ô^@ëÝ†àQ¶ke�:n…wëA¡¼ÌŠˆ$7Së­mÅËÑ�V»t	ê}P@ò( ³Ö÷ Ãàeo«U'pD³â{J1ôºÝ»9F„Ð•
“| ÁŠÐZ£‹�ÕZàcE{ßûÖiÁ%íR[¡&9Æ&+¯•:8D81¥hþm
¬×..¥©ëÚo)Ñµ½.V�„g3n]¤Oiö`o;Ð½`JHþ!:ŒâD­ºªãDöV‹ªD�ŠhþÏ@Ò �½º0%Ýå®*Á;ï˜$ÀÞª2êX�¥ì±Kp�¢�ü+ ŒÖ{GôÉi_ÕY`èÞDò@&hÍ$ŒÑ7X’)ùÒê¶Çªœw&š=HaïÖe
Á¡6ÅÐBWAïÖé#BCéNŒÎCAHþïa ¥·bpó‰C_®·]Üä¼€¢€d66	Ìµ½7H
Ù[cŒã¥p)[ê\PƒP4RØ!Cpj;+œ$ÿCdO*`E7/Î¹†Ñw@Å�âQW0Èä]G« ��ì±üg@ªF˜‚Íªø!–º—NÑd*  0?Á¬Ò$¹DoÍ :ç•Ö)fÖÅÇ€ØªmÎèD]þ
Â`"N¢/¬tfªp  Yo’bÒ­¯Ýõ‚¯ÒzGWÍHº1$³¶À‚—D§ªÞ;¶Ö:Õ§æ(âM¤·¢Í:UTœ
i¢:¨ÆÒ¶â”^�xôì[u!ùHm…â\ w­QMÂä’X[5BH’˜µª’œj«»oª"y­÷¡­²‹98•<À@V›ZˆGZßêÖuO¶V£¨¾ª°·=tu,Rº™x�jï¥Õ'cßš�~ÎšÝ·U“�‡Ö­ÔÎÒè\µZÍA4Ñ‰‘¡hþ› ¡÷I=ÐÖT£KŽ­Ô¦p‘�4"šÑ(d7“ä”}õ˜Æ ¶·ûŽ I'ÄÞv#Ä;uŠÎ’D[oˆ” 1¡EÔu¥ŒB¯¶.¥VhŸL½¢ÁI2+P½WÀXC7/ —”I†fÕ*Î;¥‘"�ü¯‚@Z'5…î±kQ£˜0%D ¬ÖÌÅ@×÷Â2À;G±nˆäDç!½ï
µcïÕ‚Î.	ZëiÔÓI˜($� @¥÷Þ !ª€Åí‘pJëÍêUòH�€4J7«-¹ä†Þ…Q“&kíZ¥ÅƒŽw±eí¦ê] ¡PÀ@J>� ! ¤ƒv@¢:�mèPõ€5ët¢^4�’RHAölÖ»øÑùækoÎ™8¡ÑzëÐQàJÙœ;KºbµêSŒ©j‘>4O U  Ì„ uÔhâ¼z1CcëF8Qe·Nñ^z­Š®*"aŽ ˆÁ`’â\pª(n�º8o0 ÌŸ�0¥¨�ÆÎ.ªÁ{¬£ƒfÝ ¨ÄTPHWPb@(Âì!1€"¤)@L„ˆ˜ˆ	D1 1É	b9AL $„˜@&Hö  b"ƒ(BP„€Ä Š˜@ BŠ s‚Äò Š“ì!P@1t!„ªâ¡Ž4k�ÍP…
ˆb"2{0�ƒÄ P„³7BÔ‡ 'Æš‰BT €˜ˆ	 &5ŠÑU�âÖ+…¢É? [ë‹ë§–´në‚°œ÷zØ@³Vü¨4[!NÅG¸ü« Ø{Q¸qÐÖ÷Ò©æ|w
ë¶¹î†É·ºnÝQ½qÌ”ÝÛ‚Á=ì·ò6öÑ/‡^­ŒnVÑ­ö"N#<”yÖ{ñ’’‚½túäÃ©õÖ.4óÎ35eþe–}w.Aµæ=�:XqcˆR°Eu.Š
hÖZÓ£o½Cjðâ˜O  ·ª˜tëŠ‘NÕÁzÝ}<ëòV»È(FÉˆPL ÐZQÄ	´uïT� ÍÀêîCxtémy«!)<,ÿé¶ÃÉ)ö²^ŠúÃàE5
z»¦ó!,ËýnÞÏ·�ì›axÔ©–·çnóG‘ü( vën8Ÿ×v½ÞKò§éœÆ¥¾ÞûAæ '’� ÄzéÁ¦‰ÛuÛ$êàÅòÖ¶6†S
ò�ñ�ùÿù¹é4òr}¹<ÌãA€¥T|œûþÝ‹Ÿ¦ÃZ�Qò Äjëóx�¥½-×4Ä`*–� ˆµV\]ÑPÃøá·}ýòçi3Ôªö~]7Õ>žÎíå»g|˜àwËÿ ÀÎn¹|áp‚ë"–  (´a~”­¾.2JÉ¿è«“tBß–¥ÔHwx<àíòqõGžÎ¾}üH88Ð%Ï  Û÷Ÿæûóëk�¦$B0ÿ ípÇã±­·o‘N)±)˜ÿ-P Æ5é<–b×»ÅàÅ“"½ß-œÏÇv½¿,�èN‡©½~÷/ôxfÐ%Ï  ®péÑ�\/o£„ €Z;NŸòòú3KÓ0�
æ‚°ô¨Ç±r[ßvÇpzŠn{ùfÑSšX°~gÞŸ†ír_çyŠ~±üë  Û6¤§‡I?-¯-=„`þAP¸�ÓÁ‡—×Ëí1ÌQ;%	Òu,Õ?F\o÷ÚãœQò— ¤÷n>Ô¾õûpó»§´=·‡wÃaó`þ[  ½ßÓiÚ.—›œ§I”Bæ/@ˆõºqða]ë.>A ù×AªÔ²ñiè×—‹é)ÖÌ@lƒ¥!Õ¾Ñc_…¢@Û6zwÂýöÖÝ4$1€ùÇ  ­oÍ?Jº•ïî«´ùøðo·oÊÉŸ•ðFÉ3H/­¹S
ö²Ü›Ÿ¢ïN,Ï ÄzÝœ?ë.×r÷s²Ð$Ï`ö(Ö0?F»½ ÇƒŠÌ¿
`uS=¥^÷ÞºÉ||z’rù´§Ã›0¿°®–æÃ©ß^n6Œ³øB¬kÇg§‡z»|„?Î®`ž@€h÷=�ŸÞõýùõòp>Hk
æLaíÞâñ³'¶ç�Ï“o,`žA€}ÙS<ÍÛå¾nzšR£‚P´‹Êû§ëÇ—Ûùpt4€ù±^÷)¥ v+SrÉ¦`[%žÎåírÅaž¤)¦èk—ã»/¸¼=ïáü0ÐÀ<ƒ«˜"Êz½sp“šŠåLÁ¶mþôî„åí;â4ª©‘ù×@ ¶—’žÞMõö³®�éHg óÏƒ€ôv¡ß¾6LCt]ÄòW  Vèbˆ¶u•œXþ÷A ¶
ÜƒöËòR[
ÑËÿˆíÖçáKi×Û7«÷cBW±<‚«»Ãqðx½\v=BŠå? E¬Ä8ue+héÝSl¯ß½lé|ÐJþ» ÄPú§÷OýíÓÕd]W#óï‚€ØÞ€ù|ÐûëÊ8LC% ±­õi>e»¼ÞùèÎÃçÀÇ—g›âüp:ôËË«ñèÅòŠ˜íâÜìw”}'ê4öT®ß>ov>ŒµxJ>€«»ÃcÔ·åÓ†9&QJ>€ ì.ß=—·+t) (¬ËîN�ßÃÛó7…ÓgÞ·]ÄòÒYÝÍÞŸ†Ëí›îÞÞU‚ùsbÜkÑÃ#ðöz“Ó4F_D,ÿ„K±a~Ðöúúi1�OóÉßoß½õQNóC ·—‹Kç�®KþP¤µ"~~o×½¡éóÁßž?½çÓ¡A,ÿ7 „½.ðOç‡R^Ÿ‰ó�ÄT,Ï „½´:ÌSXêíæ9§à«ˆå_ b}U=Çõõ^ô4Eg"–±¶í1<¤Pß®—äN#ibùsP �½�)õûË²†i2gù' ˆµ½ùøtÖÛË5Ê4¤êE,ÿ>(b}+ýèî¯/êÒ"–1Û(á¼me)Þ¹á)8»|ºµ>Í‰UÄòW @:v„óúÝË'?„h"–?Â­oiü\ÆÛýå>¥ƒT,
„¥2Nó°]/×6ûxR·—û%øÃ
Ë?‚º„§ax[¯×ìç)–?E¬VóYÜí~Ûöq�3±ü» ˆõ­…á|0Ö·Ãä#¼ZþK ˆõêÃ–×Ì:Õw±ük [ßŠŸOÉÝî÷ušÝÈ®Ùƒµl2¼{ûíù‚Æññ„éº¼!Åi šX&òW Ûœ?úvë¯4FïMò_€õÂàf_k¿HQ‚h>�­T™çƒse{YG=Fç(ù—ATBÆÃH¶[)!ê@8ÍÿÈââ¬&»Ü)>x“ü7@+fa8úvm÷"'^òÀú.ê¦Ø¸,·ÉUÍÿ.Ìv8~«Û}qŒ1Ò$ÿc°·
5úµ_Ù&xu.`¯Öàg˜õÐœsê\þmt´“žÂþv+%Æ¡WÍ?i­Àãƒì[­=ö„H—4öZ=â¤Áêºa?£´¾Ô«jLNU$ÿ&Øû§ãA¥îeéê\lÁ)$'�è½}<²së‹‰éò�@Ví=b”"+Ä©u.ÿ&H4?q‘½×n)³Û·½·®Î§’g�½×}ŠHëj»ÑG!zÑ2¤Cì¶µÍª`@4É¿Z«]Ý¬¢u+TOç5ÿÖ[½h«+šÀ;¨æ?öÊÆ˜b„mu÷êL5ÿ&hV¤EwôUÖµ­�”8‘ü» Y�@Oa¼õmi@rQœ‰æ_ l½Ý0úm«�c¢ï÷{Ñ4O“ùºÝË�Î%õ={43Ã¼ZéWt�Gï¶¬]zô“ˆw„äR:úÊ<¨µmèâ<\Bò¿‰ì	VëæÒ¤&ÛÞ[êÔ9 ’ß�{¯]u\k}s[ˆèJÑü·@ÉÆcˆ”½_ë6˜sâ= ù¿Bo»£›â(÷ÒWtI¯ï>‰æßMˆ†JÄ8Për_6¯§8)¥6ª„$"
Ñü÷Áæ7ÇmÂ�"C}Û“�¸ç?i1'Cš(÷¶A‰TÉÿ#h Ñ:»#CßlÃ~ˆÎâžÿ4R€†â5¥Aö~Ý{ŸÃ4VÔ²¡&“$@ ù4`½ÝRéÛ}Ù� Â`ÂÞý(©È­m6�St{¿³‹¨wP’ÿS˜Ð*»¦¾õ.T	�äïƒ¤ ±Á�NëÎUÕIª3@HÐ D•Nggí¾õz˜†ÄZ·l:ÕÐšP§)•½nØ ‰¾‹*•’kE»KSp[Yï­�ã0Ô²,ouS�Æ™¶.o›É9�µ]Ë}ï>8/¾BØŠV†ïõ^—ÎÕ9…@@É? AŠ­S@Ñ·&u0§A0B „d¯VÆx¨Õn]0Ð%8Š@$Œ³â›LIi¥æ%Š
%	¤Ñ¨É9“
0B�¨Bz/ˆ~ŒÊ²lÝŒðŽ&
É� YoF—\ J!'9K³}+—æ�OpX×b{‚ó�8æ/@ƒ	hô#"¸WÕA|êÞhµ1N"u‡9e€sb"¢ù  4Ñ{¥ƒ7ÝÚZu@êA¼6î’FW¶µA$jÈžŠæ¿ aV|ƒ›UÑJ5qQ›°Ã H~Â${¨ônMÜ ±²�è.$uè[K5†ÑB«;½ö /"JHþ{ º(aÖÊ "°Ò+‚l�p%…‚Þ‹‡ŸT*nf::çèŠBòÏÃÈ§N¬Gcß\ñNƒïÒi¦€ˆåß IÀÐ	‰€V&Q@V%E HN0tB¼¸^{—�$ u©~ðÑ7�!¦ f­AG´ Îœ¹ŽŠR”„€”ŽNÑèÈ]„É7£ë0µìá ’?€fFqÐÎJçcðµp×Ô³w]z2§É&ÒÙ!ºjõn ¥mÖGFïE¬ÖØ¼¨„ùï‚ Qh"Æ†Îèˆ­]DüàP°74GT0B˜@�b0²Ó©¦.b4 Òi½ ¢"B°³©hTïÄ*MT€n&1Ñüó0…‰;;% ÂuiŒ.ú.,@ z¸&€	Ìé9ˆÓÞ» b½wÅ	Ì'�b˜8@�ETSL´^U4xéEºŠwN¬øñé”®¦b¢ù/�Èžb0Bœz Ö¬u³.ÑŒ»4¿¡yªs¢b U 1Z‡¸("­vëq H!%ÿŠI�zUaGT`03Xö �üøãßÇ/7C!© bˆå!L™P bƒ�€Â¢DHU¢Œ  P"HaöÌ'PÄD˜=Ä1ˆbùŠ0{ˆA,'ˆA,ÿ*(B bùWÀ2·N¾Gï}ía�Òz¨¡>ý“?s¡B ˆ‰€X@Í@uƒ:ÝÚîvßLT�8Šæ/AX+€êÑ{YÊõÒ¨‚ˆ÷ù¿*5ÈCê¨o¥nQáA²„¦>º }ï­«øà<ÄØŠ×qde»“a˜†nuYw‰GÑf¥íLŒ!6öbÎÄC%¿a­e˜½ïûZZK’ÄA˜?ÁÞ6rœNÐk}Ù7"¼PZk	â“Š¢öêMT½ä_ …¨Ò[Ó$\ëÞ1Ê Â<ƒ uöûþðýyûx¿Ô&3#TóW  Û›Èq>ëÛë³Ì‡” ó
h»ù4€õ~/À¤cšuÛ—{•Á;'&ùÏ�‚Þ«¸ÑK³RÍÁjþPÀÖ÷ÁOƒÛ÷õJr‰Nó_¶­%yô±Ö—¥¤ip"ù×@ ­Ô}<<„v¿=kHSj óXí]‡Q¹¯mw>ˆ£æß Ò´i:˜¬·¶Ø�T« H†8i½/·-øA¡b„j/K�ß›†Oß|}‰ãy0?˜íkmªÁQÄòR¥­]ç'ìÏ7ÿô˜´w€ù=Àî¢‡Ï“|º¿ ¦Ö�ÐDÑ·]ï®î_b˜FjP€¶­åðþÊ§×Ÿ�fh˜'bVöž€ï>]äaˆ=Mx¯›úÉIè’¤J]ºœ¾8»þñ[¸ã»jh`ž@@Š4ÄÃ$—u+~<%ÿP­Äô8o×åâ-©˜ÿ2Ú^Úùtž×—'ÿ4ïãny©bËu><àg?ûôïàÝNá½»¾¾V{œ†8GlåV8Ê*%ÿ{  »Y8¾K~½ßž†¡)%à¶u<ý}ýæÙ�ÏœÌ?ØÒúðx÷ûËuÖ1Hœ�+Û¾öQ‡î	Re¯m{xÿÙáúí?_õðäk« óßéuµñø Ûóó[“ã�®‹Xž@ l×âÆ§“Ýo?ãá8k�ùÇ !R®—ðø« þïÿÀ÷&-15Ùî;Fï»Ë?ÔÖpGÞ/·Á�3ÙÁü@@šÝÄŸGÚíã%úa2#˜E–uOOaûøñëí³tv­ÌÿŠì­bþ,¡~¼^À æÏA@z»q8œOíòz«8Œâ dþ‹ Hã¾ØÃáÔnåÃùX�7±¶Æ~®/×{‹Sðð ´­¦áaÔò|¿¹aôÕ¹.
Þ­ùÏžæûõOv§ƒ6€Ì
Ø÷ãùÉö×ï0œgó«äŸ‚ H]6žðaú?¾þg—Çó#ÙÄ(yA©}MçóIÖ—�]ÏÃdP0ÿ Û­µÇ÷G¼<ÿ)æù ‘.š¿!f;4ÍJ)ÝÆºËÿ-(�®›‹!•²ßÄ…ÔcP nµžÆ±m×5¥0˜g`]9L§iÝ^oÎOƒ‡QÀ²îþÝ‡ÑîŸ·cˆ!…ÐûÒŒ¾»˜‚¡tˆOpN,ÿÌ›öñðYàú|Ýb8 dÁìQ{ñfÙ>}·ãý|ê%€ÌïA }¥?;—O7óÇ\'óÿ `¿Þ-}ïÝ|ÿôõ+Æ‡Éka·7Û}Ô˜uY .©iþPXŠõ§Ó‰ûågåËpÞæM,ÿÇ  îk�¦w½}÷¼?¦H×Éü?ƒ ¤Ôµ~îûø?¿ýöÃÃçbïË¶ÖáæÄ–ºÙ18±ü(µ^p|ÿðøÝóŸ\ìÝÓ]˜ÿ„X[6?½{pxùîÚ‡iÐ&�ü¯ƒ³m³ññá¸=zsãüÆm+ÛµÂ|î»û­ˆ�!†.K�Œ.VË¿hÛ*ÓãI.Ëó'çm"–'P ¬[ãœx¿ßvÌ1:±ü¿�"­.^Ï�“_ŸW<StË@ºŽ{sÃã“/r‰Ã4y#À<�A1óSJv]^7uƒSq–'kw³ùüe°o¾}Æü8]Åòÿ
¤Iqãa$®×m}ô3àE,O ˆµ­ØétéãóµŽ.¦9<µíº¼öñ0@M, E¬h˜=öºí:xqâ,Ï @¬Äãé¡Þ/¯;Æg±ü�@@ZYþÿ‚àd×¶,;ð?Æ¬V±÷9çž{ãFFš"²ÂIÃI:A2¶ŒQ$ ‡L"$$ ‰hÐ¤G“Öj!ùx ^�&M„("Â7î©öÞ«˜sŽñó}×ôÅÝ½_¾ùîzù8Í±‹T?ªõ9œƒ^ìòd€ ¾ü1(Âî«Çó8Úõ­­qŒYTÄ—ßEZËe<Žzl–µx øòŸA³ÕRx`yéëÕ¬L]|ù
‡½yùò¥~ÿùØÝÃe‡Ö£ö¤:Puù
iÈçi²c_A¢.²w–|ŠZ+™RpYîA4KÉzØvØ	Å%,¿EÜÖÞO�cÑ··uC4‰/¿²ÂB™ŠÇÅ¨çÌXeù)(ÒG‹µõõMN>c®qïÇ¾MžÉ¨Ë¯@kUd>“ëqC›dDË/A‘Ö�ªÃ‡Ç¸zyµi,$ØòC¸H:çÈãêGP-*a¹Ù¼§á!ÉQ××~LcVuYþ(îëæ§‡£<]¿kÀ<Ž&”å+Ð	�ehß_×ë9Í:dù!Øû5{z—Rm/—n£2ÉrzÕ¦%ïýÒ�%ª.÷0Ö€XÆÞ±ïž¡Åƒ,÷ðÞSX7ó�$$Yþì­i˜Æ¼õý¨¢sÌÂò›ØÂkÒýpÜ®OÉNó·¿ù�,÷ 7¯eŒ
vÛ %T]~
²×Ã4Þ�ìúzÛ…Sa9ƒ~€§³Õm}Ù=å!ñåg ·#p*gÈuÛÛQÆ” * ·YîÏ!Ôõåj¡�BATq	ó ¾nÛ¡q*:!z•Å’Ér½o‰åN}?.Oõ4¾ŠßÖ­A�dX¾‚yê¬¹{Û¤˜‚]î@ï�H)ÇÆµ4ª
@«ºM©LŠm»ÝÚ IÕU—_‚èØb”S	¸ô}ï™$HX&ì¶!Ûyóúz{JZ†)º*dù�°Vayi—ÛÑqbÐ¾œ@¢{EËxØ±VjJ1 ÉòklÜ!iJãõX¯{ðs�Q–¯A‚Þ+1œJêG{ª%FOH“î1ŸcÚÛëjH2B%€´ÊÀ)MÁÛëÅ¼È‘}ùhfMbŽžöÃ¢'Ä¨Ë— Øísžh{½4dBxof%Qk¯u¥ˆD•å#H·’†y»½µ•ƒN�™Ú; @� ²ü„ƒ�ÝdPö¾™§4dB–/@Òí€†á©×Û•ÈI	Y&�ÞØ‡4r¸«C’«Êò{ œ~„¦%¥èvi�Y³…åwA8aV9œ!mkÍÕ£"Q–ÿpoÞ™‡­­Gê	™Ý*ƒ—âv»m.1"BÑå§ûNõrÒÜìíÚ ¹¸F YîA‡YµåxN#úz½î>ä’~«-f‰Ñ•¢Ëßaì-¶8NÅz»V•1æBš7kÁ!¢h¾c«ûáJL-6ßƒ#Ëà€7384dù—à¶¢åAËá—í 4–¸¾«@£¦)ó-"š$]~
Âaæ&%Dk£!BEÄifc(ÀáÁCˆ*`·Š˜õäèÇÑc
	T@–¿‹.½�ú�.º…(1£'ÊòWá i­#†ièÖ·þZÃÌà­H„&�BtùW „÷n-Žy4úvÀÇ0qçÍ:ÆìA¬Ñ ¢ÙZsÓ<ˆ¯€G$À|-ÅØö~CJ	1r‰P]~ˆ%RH³šÇèÚ®¾YbÁáµV/2Z¶N7ËÀAŠ³†&iŠqÛ×Û&ƒäqª²<€Ü¬CŠ„ÀJë%R¡èò×@ô
±œÏñØÚmƒjñh-8T–§¸W©y8eÇ±¿Ò¨™QàÍ¼§!%¶cƒ‰k6B²Ì L@X«Le–(—ë±÷Œ…„‹.ÿ $|‰ðJÑœê~7Gš2`{k[Šiˆ¢½ÖèƒÄ˜©]þ!èBxM=æœ“ô­·6ê”¤ÑaFìápHdôÀ%B–¿	W]ÄÝ­YÓpŠömmœ5å.B¥âx3ºž4x«;ÌKHPP²|Â–ö*éÚ·¶{K§œLk•îCŽÌ�î.²œà$¡ðÊ�Rp_[‚BcToì’ÎÊÍbVJkªHÔeù L¨·CEï$�ÕPUBŠ&.§(è[q=Å¡ù±™eD$À©
Õå¯€îÑ€¦µC†ìí
=¥Mh¡èò5ÜéÔ˜@37@Aw’B�èò_á …êÞa@2«ÖIYÝ	*¢Ë¿	âìÞ©ç ­oÕ›¦9À›1›jV	¤€ A8œÝ�)�ju½8�%ºõ>Z�$Š,ÿîn šJ·-4ITièA!�å@� 
óf¢CN¥Ê†ÎÃ”ÊUvÛ�†AÃáG'æœhŒfšJH‡UˆŒI¡^Y¥Ôc1€p@� €õîH)ªû¦‘Y‹E¥éˆ®9j0h�TH SH…ÈòOà‚T×CL± qI}BŠ®~@"â"¤‚Èˆ�t* \@Š;œªfGÁ’yß] B!@ ª*¤‘T¡°³f†ÅÙ7urÔ V8€ !(A� TEÐÑQK`ðCwSÒ`V!.1¦ 4:H¨,ÿä’@÷î¦¡H¶D«l¹§¡¬q�FˆR`P£ªô[’‘Ökèp*ÐQ�cGÍÐ80€Ýá¢ ©€�Â%âÿ#ü¤{t�@@(â²DâBP–‚p‚„ƒp% „€*€BÐ	º  ! @ ¤$E]—„/‘p@ ƒ»ˆh
HƒA(*€8aŠ— Òœ&@Ñàpv%Tƒ ìÞÄœ"!¤¨ÑÉÎŽî¾Dhp(€¸ $Üa‰!Ä¨*f5Ù¡!!;¬©ƒ¢"Â%‚�ˆ€�@ B�N\bÌAC€õÆÝEUE)D]Äe¹·î=¤Ý[mt.1,gÞ­	K,u÷˜$…dÉ Ð{3‘aVÙûÕjCæÄx3Ùc””U]ç�o¨ûÞCŠšT]`�%÷¶¹†¤)A„4«‘qÄk«]É“A–ÿv=¦z’s¼žF³“î×å P,îj9Ü­ßj‹ESd.?èv¤xšNV/ÛªCFª¾ü!(`·žã)bm—µ"„ñ$[ß×µ¦ƒøò%(@ç.˜³ûº¿%fY¡>¦“õ·Úb¤øò—@ vX�óùŒãúyÊ\â¬vÜÖŠ$#Dô¾›¦{–·ëÛáyÉ\~ BÌ«9•·Ýªp@Œðåg ô²{NÃ»ïÛ“Îý~ºžŽå/ƒ ú¦~ÿÇËú0ŽYrùPäzúTÿì/Ÿ¿÷‡�ïÛù*ŠÔüýpüF)üÓë§�á‹oú*ËÀ«#ÞÍvÔ[Í JY~ BÕºž§¡¯O[—»”ÄAAß�xzŸ¸_.¯¸Ï£w)€oÐá!ãØ^.9Ï àòû Äì¦i|ŸØ_ÖF†tŸî×ÛËg‹÷…ppù)¸DTïR¾|×o×géE=}øBìù›v¼»?‰ÓÁ…XîAªôõàÃÝ;ï×oWÉwœ²|Š·ðÍæÿ÷Ë÷ßœâÃãóÝ«/¿ °ÝZxx¹z3BÌîòõù­Çb||úçOŸeŠy¸Š¾>{Ó4äq,²^¿×<Ïêàò#P€¦-Ù`ûf]<ÏÀ¥¾î˜R
NYf�n»�÷'·ÛÛŠ”²Š“Ë‚ üØûôø…òòôó8Càò�*}=tz¼G}{s§áÄ¶?¿2Ÿsdw
l#ïgè§×†Âðpv\^_q‡át÷Ûåéâ†óé>ñöævŽ NY>€ ìØëéñÞ·—Ï/m�1=NX?ß¢ÜÅà2ƒ€X­îæ O×çðînT3R`ëªçŽÏ/+Îs(÷�äõóMfêp7åþùù-éÃI E¬_¼œïNÛúôÚqÊÃ‘@.A <š�Ó„çOŸýašÑ¤ˆ¬e>Ÿñùù¶½Ï'¨�Ë‚Ò§OŠùýÝº~÷ðøåÛt,?—ˆ£Û8>>Èíõe=�³š€\þ”>½Þô‹9Æï®ÿsØ¾žmØÅ—_€€ôF+ïlÛõèSLA�\>‚KDë{ºûp‡õåÍNçaêÁÉe†+Ø7�çÇwbŸ/=•ó|†}^Ÿ9M…àò‡ä÷ïÏíúÝçãá~ˆ]@Ø6/ÓcÐËËëq7ŸØpùàF›Þ}�×oZ½ŸbP€^oÃ>Ìé›—n÷�é:_•Â¶²Ì™ÛË³èýœº(Û·�?N…O—OC>g8eù¸D•éÝ)m/Ÿ_ŽóxfÀå' U¬®5<<Œ·Û·Ÿ†‡9�ešâqyŠ2Ï@¹Ì  ¬ŒaÌr´m?Š§én¯ëeÍ*yäív‘4HyR[ÿôº�é¸(zÝÊô8†úüêÇ]Î÷�ÅÞž^néþD€ x;B|7®/OŸ‘RØHk«Îó#ýút�ñ¡dpù=P ìù8Ý•¡·ç*~fl*N•ŠÚæ¯Þ�?×ÿeÇo…ËoƒKDkîîßq»~ö¤C:Ý¿ÇþüÊ¨)ÎïRxÛ¾·0ž¦áíõ­”‡QŽØ)Ëo�·-j¹êQ·UšÆS,õv»ìÇ¡R,lS	çƒ»ï5`œï&}YßdHÇ;mÇõv‘Ê©œ·ËÛë63‚«øò5¸DÕðønð——ïŽðEã|jíírX*Cw_>‚ïGâC>úuÝý<„T)Ëoƒ€ØáÏïhëÓ%ké (¬­ŸçCýþùe/÷'¤PP›Ã—g»¼}·�ç“E¹ü.(ö-¤ikÙ÷<äÈr4cÉçtÝ^0•45
@a­v:¿/þürÙæ’r¹Ë~Û.×gM*œ5Ôq
¨­·#J,Ó)íëë�…„ô^9ßŸÂ¶~zÒ”e:ÿ€õù»oòô>žÏ§Ñ^Ÿ>©œïàîäò5À÷Ãîîãþúí+Êý €Âv3œÞ§íåå9œË,<D|ùB¼Óû‚ãú²†±ŒG¢,¿Øzèôðèmý|õ|J�\fp‰h­Çû¯†xûîÓ3q’wç»Ôž¾Û8¼› ¦„ßDO_Ì§º½^{>".”`~s?¼Ë—çOu,søð8¤×Ëç›?Þi:AAÛˆÓ‡øë÷u,Óùá}”ýù[¿›Ë\¾L¸¾}¿M÷ãdÚÉåkÂÞÖÏäúùö6�¦SÀíé¥=„³ˆúòoAˆÛQY¦ùör}écŠÓ8—¸¾<k$½›°ÿ§ÞîJžãŽ××‹NóHñå·@�xƒŸÓØ_ëS1„ùþ”�ãí­ŽãÜ“`¿¡Îgàõé9ÇûA�TSyŒÓz]Ÿ5Dœ¦{~]ñXNPŠ/ÀÖƒ§÷ï‹|þô$y¸£Cðà‘NÅ¶×'çÁPÀjUÎ§ÌãõíUãïÒÝx½®—qN{_~ŠxëmÈ³°_�C*H&Ë/A¯²ŽåNkÝÖ�)f	¶$X¯†²÷ª@ŸÊÀm»Þ:ÂXæq¾î·‹j†wãÐoO—$óœÐ6÷ùñ}	ß^Ÿ(©÷çYnÏÏ·f„ÐdùñVMÓ»�/õí��(âË�A÷ÃC>Ÿà—Ës%ŸNçð´¾È4–œ PŒÖæwqÔËó•4ŸOY®ë§Û4ÝK»,¿�M†\¬Ö£{é9�@}ë=¥\\ƒ/_‚"î‡y:Ÿ²__Ÿ›†E|ùqßBŸïNÁ®oëŠ\‚ø2ƒ"ÞÏé�åz»VOc„B|™@·}7=?\ßž�“‡ðî¬_Ÿ^Sšç¡F(l{Åð˜ŽãzÝ¦|Êa9ƒ"­»�ç!`»¼ºŽ¹ Šø2ƒ"Þ7iw÷ó]Øž/*aÈ±ñåŸƒ"^}ÇüXD.ß¿eŒ³òPÀ½mž‡ÇGo·Ë[IQ��å× ˆUØ4Þ¡õË¶J
|ùÇ {³cšï�·çÏkãØéâËoƒ"½UæiHX·�Z2TÕ—¿²…®cà~€q˜‹§Ã¯]â0zìËÿE¬ú‘Nç¹¯×·ÈÓ0tèòs�f]s’`ìHÌCúe¿†�BpYþ)è•(eŠ{íW;bŠAqØŠÏ�çòe¿}Â7cG+¾ü´½u�¦9Úíõ’Ò0ƒ.÷p?|Ä)7Ø­_stÕå¿€VM4Ý§©¯Ïëê‡–‡ºÍñcŒ<.O¨Ã€SUU,ÅÓ)‡·ëënå4ŒMÂB,3èm7™Oó`Çõ²rÄé²ütk]eòŽ¾öŠ¡¥,g�ÖÌ9Œ‚vô?¥, Ø�:Æ÷³ÜðlÕÛ—:ß„ÖÛ1èœ‹ìm{FõT‚®õ¨ÞÍª}‰èÜ2Ó]‚¾èj=Ÿ_Ï›.ÿ	n[nÓ¹Û×£¦Fª/?­wròH»‰æ|²pð²š¦”½µ£9‹¦ !,?ÝjbJHÍ÷JÉ:œ<oÛ­6Ma´ìj†1;Û†VPJD?º`RºèòÏ@Ðl÷àc	ØnÛs3ŽS	zõuï=å˜ƒ,#7?BiNÚz;¬cœÇŽV×ÛU“+T]~ˆ.k}”D»î×˜Ã€ºüØŠ—9þ™ýî¥ü¿á¼û<úò3�Þ`*§@o·ãý�#�7ßKŒ‚°|	·#lsžJY¹›Ë0L3úfÇÖr’±.ËO@ÒûVŽ©œ4rß^6³q**Öo]P<Iv‘å#Ht¯j9e÷}½­{�‚â"Ë�áBvïŒiTƒÕ¾é¨±ô½ÖD-È€ [‹­L%š¯íŠhó¥P—;Ð¼»GToG
yÖàÇqø–BNbµ[�IBPY~„Óu§Tê^o­É�Î‚~Ø±‚ª)Ä•åK¸{SÅ£q=#æ‘MŽý>åY‰^¹ÕÔ!Ë×X"½YK±t½õ¨ZTEÅz¯Ó�äÛ±m*)H�å+ð×³¿Ó¢·zÅzo“/NoABTDVK®!æ+7*§ÒÙ÷n’${FËßiÞÜBNo}GL!†$âì^CL'[Û;�´HT ÝX‡<¤Ø¹îvDÌ™ê~@R‰YC èò7ÐíÈÇã¹L•ûºÑïòíãÓòK�DGU¦4´ýèf9%²ü	\àæ.Y“n[Ìqê&µ�q`¶¾WS\Ð«vÍs½¿Þ6$¹L¬:up�„,„)ÝºQ&F·¶ªÔÌ°DÈò;pÜ­›¦!%÷M‘M%"ì<Ò¨Ù|Ým/e>umÜ7ïiG…ô�šE…TYþ®¦î¦¡¨š÷4HtÑåïƒìp×¢‘²›‰¥’dW'b™%££Fª†Q8›˜¦!÷ýJŽŒI²	pÑå„nÝ]:Ú€0* ‡µ®$f.	\"(+­Ù©Ü'^öíé9Çbã÷ŒË*�æG¬S¸oùº_�M¦©(Z«+˜ÏiØzm­†¨)¨‚ Í]b‘`lP§ª@ØmW/cH¾_Ô E’)ÉNHAh[nƒêr"7*¼J¾k¾n{—A† $Í€5š„SRWYþèðGCdµ¦SžÄ¬¯L’dÒIÑå “T±Ê€a.àzÛR³ªB!A|ù1( Ý	š7É)!øV7z‰C.?Æé¢ðCM¦4Ä·úzíRP,S "�åÏƒ�dˆ´*Heµ®W÷¡H4ßC×Y#÷Ú­‹žL.¿Iw@ƒDˆtiÑ¨ºÂ‰.$j÷ª]$PT�îÝc(!Ôƒæ‰UÈòc¸P Ž&’KŠfµ‰³Š(½õÄ¬ÒêNKL‚8:Ž(i;l?¤‹„�\ t.ê0„A@ìÁ4$‰]Ô¼wJÊ�›ÖbÊ"ØÑ’«@–$�.
e3Ó’†£o×Z�û8‰²íµ9JH�Ñ Yþ‰‘*�ÎJg÷#uÑ ¢º| Í»kÊˆÖ7aÎ’¼w‡‡˜K×ZÉEÄépf�§úÖSŸ5k$Å©Zß%åÞ×ýÚ{F(H �ââA$&Ø..çàÁ®pTEˆS–¿º»�‘EŒêR‚Ù¡Ñ BY~
(0Y":kÒaˆ®mÝš& ÜEB�(½™‹	ªÞ›{ˆ9öÐ,JrªJ��½FR:kÁ¤9}ë;4¦(.BP â"4£k¢uXq£
,¨† \~‚  )bæf(¢lì‰du*“D†îÖ]”åoÃPèª
ˆ®F!ˆ&À;²&hÕª-Jcè-9…¬µj’$…JÂ•å§ ƒ vÖÄr"×˜4Ž,Í{o&d”,
)1f‰Òm—Þ¡!0t%"Ë¿�;LUSz7zpaw¸¨,¿)K„ öÔ‚ÆY]¸·*{w“ J€p§‚Êîæš5D£Á€ ÂÎ;A5
H‚Ëo€ K„£+©ƒÄHtCs7UP —%Ã•À) u§D@$ ¸ÓŠP ’€ˆ³C¢•02xëÿçÿAÂÞMBASE      JI  xÁA  ƒ°YãúÀ þµ,9HÓ¨*b…ŒäEk!¢:&›Ú˜Ë±
5‰®h›M¶&N77Ì$%Z¡ÜVT 86YÓÜXUK‚)·¢
V.ª…kl6\DÌ‹Õd-\F¬ájV­h�“LeU‚”Uƒ�ºE±(kÕ6" uËÕZ­RÛPÝª)Z�hB‚d5h@­­InA£´¥2`‘À@b ¬MH A€	¸˜Ö@€\0  –‘0A \ $eNA6±Ú,k0ÁÔfc&®p%®”†”Íj›[+`Ñ0+JDéÔ€-ÄYQÁ”¨ Ô™ ZÑfÍ6*#sdƒ�¡Ö¶5•,‡ké6³5€Ö’,F9R@D£‘0Xº\±‚aU�Ä-jLæD7% �‘¢“z
ê4LBPOS      HO  xÁA–E DÁÁ'JWÆ¯À•ÇqÃµ8º¿~ÿ÷åããã�ç_ÏçÏŸçüè½ïýÛçwïÞ÷<ëó9g—ç´Ó²Ýub{ÜñVÏQî™šî]Ç¹�’s3“«‘»´p”œ›ãÜ½¦�‚bâle¹Ë6¢gMÊ¬,'6+¶´E›™4ØVX3k Ö°`³A§ Ì0äDŒ€£Á&aØ 63$A°†ÓÀP c†Ì„Å‚µD ËD²ÉFc„� “°F‚12 ­Á À²X"a@Â‚…˜@ÍB- "!Ðš´›B‹H
L“Õ" ÑZ[¨afË˜™ÍÖ8XLóíÀÀìnžfë¯NVçÏ £³óõÛ÷÷½Î26M§NfãÏuæÜ…«Ö²»{ž˜{Ø}×Þ¥ìôù>ïéi÷düàu4nCNF4      Ÿb  xÁAnÓ@€áßžyžÔIÕ�Ü¦T‰K.ÀÞžKq<6l"A…A²Lƒ·ÍóÌð}ÅýèçŸÊ‚|ù”ýæG£(ç»c¹XïSäGÝ”=[9n´ÂD+Œ¾Õ
ë·‰@·E :š¡)_ªš¡5¡£Õ€‰^cbÒÑ¾Â ž6â´ÆD7˜hàX—Nm×ê'L4“@L¢kb*�.0Ñ{LtOtºÂD¿`¢_1ÑkïÁDo1ÑÀD&`¢ï0LÄD¢‹8õ˜hEL¢K¾}4&@Ää°Ñ€ëÚìð11&B²z€«¿;8Öˆ.0úmßáûÍ/ÞÖ0‰Õ¦1ë`;ÁV+&úzZížï‡ö°ûÓôÜü{ºu6:8®x�—çiÄ—\Œw�ói“`ãÎ<�À‡õ)�@Œ\°„Ñ§ä+pÌf›ýîyØœs
ùLxus1/æ9“=Ì®JoRž^&’¨N¤`À’qÍXWfrI8/žÏë)Aæ"FrI'ÍhF3šÑŒf4£ÍhF3šÑŸüäÅÚëTEXT       Ñø   xÁÁjƒ@àÿQæÌ23®Ž<¬º±AcDm '!%‡J$”>¿c¸D`c„ÇrîF„JróIS	EÒU’©OÖJ¼–)4�Ì™Ú°FœÞOROËc'ÉK.JRV¡ß�ÞOROËc'±RµT#eÌŸce>ªw’s!BRVá£z'¦ª†ö+Nèë-µ”·é:ÙV·ë_ê~^w\Bó�u9�]¢©Ïr\®í€ÔRFÝ„}íîß;nqxÇ¸ÅYÑ×$N�)@6&CLIP       	           "<AlignableSequences trimStringency="Medium"><Sequence name="8_Ubi-R_TSS20210923-027-08169_F02" ID="0" isTrace="1" use="0" sortOrder="0" trimmedRange="54..1131"/><Sequence name="9_Ubi-R_TSS20210923-027-08169_G02" ID="1" isTrace="1" sortOrder="1" trimmedRange="0..1091"/></AlignableSequences>  ‹     ÿ BC N srôe”```pðpáó³2Ô3ãö·²*Í+Î/*IMábÊqqQjZjQj^r*Ã î×Ér6   ‹     ÿ BC Ÿí•=®T1…/?‚[.\!"ä�()H”"t4ô¯ ‡%<G.\"±Ø	K`	ì<óî0T4 ¤9Rt&‰;¹š|¯ïnG}z¼m7¿½Ä‡Û½íííí=ÙÞÜÚ¶ËüUŽ½mÃl»Þýzüãî_v·û‹“ù¯'ë?žô¿Ò¶Aú«G?ò=Ë6Œ¼�RK¬A%KY‚Ë(ÞgN;ðP±RJL^6AºÌ qja¬£ƒ›,"ŽÖ¥ŽB¤�Â¹T‹ûtäŽŒ¹6¨±°g^`.ÓBÁ j® ™ÅtáœðˆÎÚ¨�aå¾Ðt#•ê˜õB�¡6ÐŠÑuUF–X¡Ö#¾2F,kOåA©I„:”Išs‡ˆ0Œ¼‚Ú2j²z¬Lî«Pg²ê‚–'�<=È
ÉÄÜˆ!;@½èh¬ôìr0géYŸMÎ`³Q$Œ¢^-Y¹ª5#€
ÝóÀfÒ­Í
“œ½c^L–Ùêk9Öa0¥Uƒs7˜CJ®™‡gÕQ!?Mä·È»dµW­4+[™M�¹B—Ù)¯²Œ5³|Õü”à$Ñyjæ1 FºüvÖYg�õwtgë‡¬÷¬ó¬Oƒâ5D¯Çì~y÷êdüÉ�+¿·ûÅµ?¿ò÷?­Ù`u-<y¹v^Ú^šN#£#0ù Lnf`º'H�ÄtB]ZÏG8Ú*m(:G4qI^�·š`3HXJ-š,´Ã‹¿,)ÚYª6Â’ä`¶t
ˆ6KB£Ã¨°IÂhIÂ’4¹‰³ÕÆùö¯é IO\M½DéÉ'Y|À`òðˆÃŒYŒt&æŸ3Ï	VPâ_ÿƒÎ:ë¬ÿ_ß—çŽ¼c  ‹     ÿ BC             !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  DŽ<?xml version="1.0"?><Features nextValidID="27"><Feature recentID="0" name="sgRNA1" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="550-569" color="#a6acb3" type="standard"/></Feature><Feature recentID="1" name="U6 terminator" type="misc_feature" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="646-652" color="#a6acb3" type="standard"/></Feature><Feature recentID="2" name="AtU6-26 promoter" directionality="1" type="misc_feature" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1"><Segment range="107-549" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;&lt;div&gt;Synthetic construct guide RNA, complete sequence&lt;/div&gt;&lt;div&gt;GenBank: KT827739.1&lt;/div&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="3" name="gRNA scaffold" directionality="1" type="misc_RNA" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="570-645" color="#00ccff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;guide RNA scaffold for the &lt;i&gt;Streptococcus pyogenes&lt;/i&gt; CRISPR/Cas9 system&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="4" name="KanR" directionality="2" translationMW="30729.62" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="11431-12240" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;aph(3')-Ia&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to kanamycin in bacteria or G418 (GeneticinÂ®) in eukaryotes&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;aminoglycoside phosphotransferase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="MSHIQRETSRPRLNSNMDADLYGYKWARDNVGQSGATIYRLYGKPDAPELFLKHGKGSVANDVTDEMVRLNWLTEFMPLPTIKHFIRTPDDAWLLTTAIPGKTAFQVLEEYPDSGENIVDALAVSLRRLHSIPVCNCPFNSDRVFRLAQAQSRMNNGLVDASDFDDERNGWPVEQVWKEMHKLLPFSPDSVVTHGDFSLDNLIFDEGKLIGCIDVGRVGIADRYQDLAILWNCLGEFSPSLQKRLFQKYGIDNPDMNKLQFHLMLDEFF*"/></Q></Feature><Feature recentID="5" name="BlpR" directionality="1" translationMW="20638.01" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="8644-9195" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="function"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;Streptomyces hygroscopicus bar&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to bialophos or phosphinothricin&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;phosphinothricin acetyltransferase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="protein_id"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="MSPERRPADIRRATEADMPAVCTIVNHYIETSTVNFRTEPQEPQEWTDDLVRLRERYPWLVAEVDGEVAGIAYAGPWKARNAYDWTAESTVYVSPRHQRTGLGSTLYTHLLKSLEAQGFKSVVAVIGLPNDPSVRMHEALGYAPRGMLRAAGFKHGNWHDVGFWQLDFSLPVPPRPVLPVTEI*"/></Q></Feature><Feature recentID="6" name="dCas9" directionality="1" translationMW="158203.57" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" consecutiveNumberingStartsFrom="2" maxRunOn="7403" maxFusedRunOn="7403" detectionMode="exactProteinMatch"><Segment range="2892-2915" color="#993366" type="standard" translated="1"/><Segment range="2916-2918" color="#cc99b2" type="standard" translated="1"/><Segment range="2919-5405" color="#993366" type="standard" translated="1"/><Segment range="5406-5408" color="#cc99b2" type="standard" translated="1"/><Segment range="5409-6992" color="#993366" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="locus_tag"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;RNA-guided DNA-binding protein that lacks endonuclease activity due to the D10A mutation in the RuvC catalytic domain and the H840A mutation in the HNH catalytic domain&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;catalytically dead mutant of the Cas9 endonuclease from the&amp;nbsp;&lt;i&gt;Streptococcus pyogenes&lt;/i&gt;&amp;nbsp;Type II CRISPR/Cas system&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="protein_id"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="DKKYSIGL,A,IGTNSVGWAVITDEYKVPSKKFKVLGNTDRHSIKKNLIGALLFDSGETAEATRLKRTARRRYTRRKNRICYLQEIFSNEMAKVDDSFFHRLEESFLVEEDKKHERHPIFGNIVDEVAYHEKYPTIYHLRKKLVDSTDKADLRLIYLALAHMIKFRGHFLIEGDLNPDNSDVDKLFIQLVQTYNQLFEENPINASGVDAKAILSARLSKSRRLENLIAQLPGEKKNGLFGNLIALSLGLTPNFKSNFDLAEDAKLQLSKDTYDDDLDNLLAQIGDQYADLFLAAKNLSDAILLSDILRVNTEITKAPLSASMIKRYDEHHQDLTLLKALVRQQLPEKYKEIFFDQSKNGYAGYIDGGASQEEFYKFIKPILEKMDGTEELLVKLNREDLLRKQRTFDNGSIPHQIHLGELHAILRRQEDFYPFLKDNREKIEKILTFRIPYYVGPLARGNSRFAWMTRKSEETITPWNFEEVVDKGASAQSFIERMTNFDKNLPNEKVLPKHSLLYEYFTVYNELTKVKYVTEGMRKPAFLSGEQKKAIVDLLFKTNRKVTVKQLKEDYFKKIECFDSVEISGVEDRFNASLGTYHDLLKIIKDKDFLDNEENEDILEDIVLTLTLFEDREMIEERLKTYAHLFDDKVMKQLKRRRYTGWGRLSRKLINGIRDKQSGKTILDFLKSDGFANRNFMQLIHDDSLTFKEDIQKAQVSGQGDSLHEHIANLAGSPAIKKGILQTVKVVDELVKVMGRHKPENIVIEMARENQTTQKGQKNSRERMKRIEEGIKELGSQILKEHPVENTQLQNEKLYLYYLQNGRDMYVDQELDINRLSDYDVD,A,IVPQSFLKDDSIDNKVLTRSDKNRGKSDNVPSEEVVKKMKNYWRQLLNAKLITQRKFDNLTKAERGGLSELDKAGFIKRQLVETRQITKHVAQILDSRMNTKYDENDKLIREVKVITLKSKLVSDFRKDFQFYKVREINNYHHAHDAYLNAVVGTALIKKYPKLESEFVYGDYKVYDVRKMIAKSEQEIGKATAKYFFYSNIMNFFKTEITLANGEIRKRPLIETNGETGEIVWDKGRDFATVRKVLSMPQVNIVKKTEVQTGGFSKESILPKRNSDKLIARKKDWDPKKYGGFDSPTVAYSVLVVAKVEKGKSKKLKSVKELLGITIMERSSFEKNPIDFLEAKGYKEVKKDLIIKLPKYSLFELENGRKRMLASAGELQKGNELALPSKYVNFLYLASHYEKLKGSPEDNEQKQLFVEQHKHYLDEIIEQISEFSKRVILADANLDKVLSAYNKHRDKPIREQAENIIHLFTLTNLGAPAAFKYFDTTIDRKRYTSTKEVLDATLIHQSITGLYETRIDLSQLGGD"/></Q></Feature><Feature recentID="7" name="KRAB" directionality="1" translationMW="7404.74" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" consecutiveNumberingStartsFrom="11" maxRunOn="7403" maxFusedRunOn="7403" detectionMode="exactProteinMatch"><Segment range="7152-7337" color="#993366" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="ZNF10"/></Q><Q name="gene_synonym"><V text="KOX1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;KrÃ¼ppel-associated box (KRAB) transcriptional repression domain from the human zinc finger protein ZNF10 (&lt;a href=&quot;http://www.ncbi.nlm.nih.gov/pubmed/8183939&quot; title=&quot;http://www.ncbi.nlm.nih.gov/pubmed/8183939&quot;&gt;Margolin et al., 1994&lt;/a&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="protein_id"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="RTLVTFKDVFVDFTREEWKLLDTAQQIVYRNVMLENYKNLVSLGYQLTKPDVILRLEKGEEP"/></Q></Feature><Feature recentID="8" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="10753-11341" color="#ffff00" type="standard"/><Q name="direction"><V text="LEFT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="pSa ori" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="10203-10638" color="#ffff00" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;origin of replication from bacterial plasmid pSa&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="Shine-Dalgarno sequence" type="RBS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6905-6913" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;full consensus sequence for ribosome-binding sites upstream of start codons in &lt;i&gt;E. coli&lt;/i&gt;; complementary to a region in the 3' end of the 16S rRNA (&lt;a href=&quot;https://www.ncbi.nlm.nih.gov/pubmed/7528374&quot; title=&quot;https://www.ncbi.nlm.nih.gov/pubmed/7528374&quot;&gt;Chen et al., 1994&lt;/a&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="11" name="rrnB T1 terminator" type="terminator" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="9948-10034" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;Escherichia coli rrnB&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;transcription terminator T1 from the &lt;i&gt;E. coli rrnB&lt;/i&gt; gene&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="12" name="rrnB T2 terminator" type="terminator" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1"><Segment range="9829-9856" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;transcription terminator T2 from the &lt;i&gt;E. coli rrnB&lt;/i&gt; gene&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="13" name="nucleoplasmin NLS" directionality="1" translationMW="1739.18" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="7403" maxFusedRunOn="7403" detectionMode="exactProteinMatch"><Segment range="6993-7040" color="#993366" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;bipartite nuclear localization signal from nucleoplasmin&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="KRPAATKKAGQAKKKK"/></Q></Feature><Feature recentID="14" name="SV40 NLS" directionality="1" translationMW="883.15" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" consecutiveNumberingStartsFrom="126" maxRunOn="7403" maxFusedRunOn="7403" detectionMode="exactProteinMatch"><Segment range="2847-2867" color="#993366" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="locus_tag"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;nuclear localization signal of SV40 (simian virus 40) large T antigen&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="protein_id"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="PKKKRKV"/></Q></Feature><Feature recentID="15" name="SV40 NLS" directionality="1" translationMW="883.15" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" consecutiveNumberingStartsFrom="126" maxRunOn="7403" maxFusedRunOn="7403" detectionMode="exactProteinMatch"><Segment range="7059-7079" color="#993366" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="locus_tag"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;nuclear localization signal of SV40 (simian virus 40) large T antigen&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="protein_id"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="PKKKRKV"/></Q></Feature><Feature recentID="16" name="SV40 NLS" directionality="1" translationMW="883.15" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" consecutiveNumberingStartsFrom="126" maxRunOn="7403" maxFusedRunOn="7403" detectionMode="exactProteinMatch"><Segment range="7095-7115" color="#993366" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="locus_tag"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;nuclear localization signal of SV40 (simian virus 40) large T antigen&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="protein_id"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="PKKKRKV"/></Q></Feature><Feature recentID="17" name="SV40 NLS" directionality="1" translationMW="883.15" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" consecutiveNumberingStartsFrom="126" maxRunOn="7403" maxFusedRunOn="7403" detectionMode="exactProteinMatch"><Segment range="7344-7364" color="#993366" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="locus_tag"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;nuclear localization signal of SV40 (simian virus 40) large T antigen&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="protein_id"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="PKKKRKV"/></Q></Feature><Feature recentID="18" name="CaMV 35S promoter (enhanced)" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="7922-8599" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;cauliflower mosaic virus 35S promoter with a duplicated enhancer region&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="19" name="CaMV poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1"><Segment range="9202-9376" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;cauliflower mosaic virus polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="20" name="NOS terminator" type="terminator" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="7445-7697" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;nopaline synthase terminator and poly(A) signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="21" name="Ubi promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="739-2729" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;maize polyubiquitin gene promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="22" name="LB T-DNA repeat" type="misc_feature" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="9526-9550" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;left border repeat from nopaline C58 T-DNA&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="23" name="RB T-DNA repeat" type="misc_feature" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1-25" color="#ffe4c4" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;right border repeat from nopaline C58 T-DNA&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="24" name="HA" directionality="1" translationMW="1102.21" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="7403" maxFusedRunOn="7403" detectionMode="exactProteinMatch"><Segment range="7371-7397" color="#cc99b2" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;HA (human influenza hemagglutinin) epitope tag&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="YPYDVPDYA"/></Q></Feature><Feature recentID="25" name="3xFLAG" directionality="1" translationMW="2730.72" type="CDS" allowSegmentOverlaps="0" cleavageArrows="2840" consecutiveTranslationNumbering="1" maxRunOn="7403" maxFusedRunOn="7403" detectionMode="exactProteinMatch"><Segment range="2775-2840" color="#cc99b2" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;three tandem FLAGÂ® epitope tags, followed by an enterokinase cleavage site&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="DYKDHDGDYKDHDIDYKDDDDK"/></Q></Feature><Feature recentID="26" name="M13 fwd" directionality="2" type="primer_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="7706-7722" color="#a020f0" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;common sequencing primer, one of multiple similar variants&lt;/body&gt;&lt;/html&gt;"/></Q></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  Ï<Notes>
<UUID>ace6b3af-71bf-44f1-ae85-60e1c12cbe15</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<CustomMapLabel>pBUN6I11-AtU6-ALKBH10B-sgRNA1-35S-Cas9</CustomMapLabel>
<UseCustomMapLabel>1</UseCustomMapLabel>
<Description>CRISPR/Cas based plant genome editing and gene regulation; expresses dCas9-KRAB, gRNA scaffold for insertion of target sequence (OsU3 promoter), Bar resistance.</Description>
<Created UTC="21:24:26">2018.8.6</Created>
<LastModified UTC="6:19:7">2025.9.4</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
<References>
<Reference volume="14(1)" authors="Xing HL, Dong L, Wang ZP, Zhang HY, Han CY, Liu B, Wang XC, Chen QJ" journalName="BMC Plant Biol." title="A CRISPR/Cas9 toolkit for multiplex genome editing in plants." type="Journal Article" pages="327" pubMedID="25432517" journal="BMC Plant Biol. 2014 Nov 29;14(1):327." date="2014-11-29"/>
</References>
</Notes>
  Y     –         
?????                                                                                                       ÿ d      HO  d               E              ÿÿÿÿYô? P                                                                                                                                                              3<?xml version="1.0"?><EnzymeVisibilities vals=""/>
   )<?xml version="1.0"?><CustomEnzymeSets/>
